| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Inside the cell, various dynamic movements of its interior structures are observed, such as the cell nucleus’s movement from the edge to the center of the cell, or the cytoplasmic streaming throughout the cell. We have been proposing that intracellular organelles such as the endoplasmic reticulum (ER) play an important role in these dynamic movements as mechanical elements that generate and integrate forces. In this research project, we were able to demonstrate that intracellular movements with organelles as mechanical elements are important for cellular dynamics. The dynamics included the mode of cell division and the formation of the body axis of an individual. The studies were conducted by combining microscopic observation of a nematode, Caenorhabditis elegans, and mathematical modeling.
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