| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
The field of ‘genetic code expansion’ or ‘genetic code engineering’ encompasses two directions: Technology developments for in vivo incorporation of non-natural amino acids into proteins and applications of this technology in medical and industrial spheres. The present study successfully addressed both aspects of the field. A new approach for creating ‘identityless’ tRNAs, which are of fundamental importance for expanding the code, was thus established. Another achievement was a novel method to improve the antigen-binding of antibodies, which illuminated a new direction of protein engineering based on expanded codes.
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