| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
We have developed a chimeric molecule in which the microtubule-binding site of dynein is replaced with the DNA-binding site of a transcription factor to create a new protein-based molecular motor that moves on DNA. DNA nanotubes were prepared as tracks for this new molecular motor. The recognition sequences of DNA binding sites were incorporated into the surface of the DNA nanotubes. As a result, the DNA nanotubes showed a smooth sliding movement with an average speed of 220 nm/s. Moreover, we succeeded in creating a dimeric motor that moves processively on DNA nanotubes.
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