| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
|---|
| Outline of Final Research Achievements |
Epigenetic regulation by histone modification is achieved by the cooperative action of writer, eraser and reader of histones. Cdyl family molecules and HP1 family molecules are chromodomain-containing proteins that can recognize methylated H3K9. In this study, we analyzed the functions of Cdyl family molecules and HP1 family molecules in mouse sex differentiation, to clarify their role as the reader molecule of methylated H3K9 at the Sry locus. We established Cdyl, Cdyl2, and HP1α-deficient mice and then observbed their phenotypes. We did not find abnormalities n sexual differentiation in these mice. However, on the contrary to the initial expectation, genetic analysis under the Jmjd1a-deficient background revealed that Cdyl and Cdyl2 positively regulate male development.
|
