Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
The pluripotent cells are established in the early embryo during the development of multicellular organisms. In this study, we tried to compare the transcriptional networks for converting from pluripotent cells into primordial germ cells. We provided evidence that Prdm14, an essential factor for germ cell specification in mice, is critical for the early development of newt embryos. Furthermore, we identified that the transient downregulation of PRDM14 expression is vital for human germ cell specification.
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