| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In this project, we revealed the involvement of reduced chromosome oscillation, an iterative chromosome motion on the spindle, in chromosomal instability in cancer cells. When kinetochores get closer to spindle poles through chromosome oscillation, a kinetochore molecule Hec1 is phosphorylated by Aurora A on the spindle, facilitating the correction of erroneous kinetochore-microtubule attachments. In cancer cells, this mechanism is defective due to reduced chromosome oscillation, resulting in the increase in chromosome missegregation. Our study revealed a mechanism of chromosomal instability frequently found in cancer cells, paving a way to a novel anti-cancer strategy.
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