| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
|---|
| Outline of Final Research Achievements |
Mechanisms of left-right (LR) asymmetric development are evolutionarily diverged and not understood well in invertebrates. To address this, we studied mechanisms underlying the LR-asymmetric development of the embryonic gut in Drosophila. We revealed that nuclei in the visceral muscles of the embryonic gut densely align LR-symmetrically along the anterior-posterior axis. We also found that the LR symmetry of such collective nuclear arrangement is essential for the LR-asymmetric development of this organ. Collective nuclear behavior depends on Wnt signaling and LINC complex, which are required for the LR asymmetric development of the embryonic gut.
|
