| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
The gamete fusion, which is the climax of fertilization, is presumably activated by the interaction between IZUMO1 on the sperm side and JUNO on the oocyte side, followed by an intermolecular reaction consisting of multiple factors, including the IZUMO1 second receptor on the oocyte. In this study, we newly identified the sperm factors DCST1 and DCST2, which are conserved as essential fertilization factors in invertebrates, in mice and humans, and found that Dcst1/2-deficient mice are completely male sterile due to gamete fusion failure, as in nematodes and flies. The analysis of the detailed molecular mechanisms involved in the DCST1/2 molecule, which has been conserved over nearly one billion years of evolution, is expected to greatly advance the study of fertilization.
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