| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
|---|
| Outline of Final Research Achievements |
Wnt1 and Wnt3a are locally expressed in the dorsal region of the neural tube in mouse embryo. We found that these Wnt ligands localize to the apical side of the expressing cells. The Wnt-expressing cells undergo a dynamic morphological change during development, elongating along the dorsoventral axis, and secretion of these Wnts is required for this morphological change. Our analysis revealed that activation of the Wnt/b-catenin pathway, one of the Wnt signaling pathways, is important for this morphological change. Our results strongly suggest that the apical localization of Wnt maintains Wnt signaling activity in the dorsal region, resulting in the activation of cytoskeletal factors and cell morphological change.
|
