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Elucidating the mechanism of strigolactone signal transduction in a parasitic plant Striga

Research Project

Project/Area Number 18H02459
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44030:Plant molecular biology and physiology-related
Research InstitutionNagoya University

Principal Investigator

Tsuchiya Yuichiro  名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 (00442989)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsストリゴラクトン / 寄生植物 / ストライガ / 受容体 / 発芽 / シグナル伝達 / ケミカルバイオロジー / 植物ホルモン
Outline of Final Research Achievements

A parasitic plant called Striga causes huge damages on crop production in Africa by parasitizing monocot crops including maize and sorghum. Dormant Striga seeds sense host-derived strigolactones (SLs) for germination. We took chemical genetic approach to identify novel components involved in this process. We performed two types of chemical screening, one for suppressors of SL-induced germination, and the other for small molecules that break upper-limit of Striga germination rate. Both screenings identify several hit molecules, and we performed identifications of target proteins and biochemical characterization of these proteins.

Academic Significance and Societal Importance of the Research Achievements

ストライガをはじめとした寄生植物特有に見られる受容体のコピー数の増加の生物学的な意義が見出せていない現状において、本研究より受容体間に機能的な相互作用が存在することが示唆された。すなわち、土中に存在するSLの種類により発芽するか否かが決定されることを示唆しており、ストライガが寄生する宿主の種類をSLのブレンドを認識することで起こしていると考えられた。また、受容体ネットワークを制御することで発芽を抑制できることより、この原理を踏襲した発芽抑制剤の開発が可能となり、自殺発芽とは異なるアプローチでストライガの寄生を抑える方法へと発展することが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (18 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 8 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] University of Toronto(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 自殺発芽剤による寄生植物ストライガからの防除2020

    • Author(s)
      土屋雄一朗
    • Journal Title

      植調

      Volume: 54 Pages: 13-16

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Enantioselective Synthesis of Polycyclic γ-Lactams with Multiple Chiral Carbon Centers via Ni(0)-Catalyzed Asymmetric Carbonylative Cycloadditions without Stirring2020

    • Author(s)
      Ashida Keita、Hoshimoto Yoichi、Tohnai Norimitsu、Scott David E.、Ohashi Masato、Imaizumi Hanae、Tsuchiya Yuichiro、Ogoshi Sensuke
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 3 Pages: 1594-1602

    • DOI

      10.1021/jacs.9b12493

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 人工ストリゴラクトンの設計2019

    • Author(s)
      土屋雄一朗
    • Journal Title

      植物の生長調節

      Volume: 54 Pages: 49-53

    • NAID

      130007668427

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「魔女の雑草」寄生植物ストライガの撲滅に向けて2019

    • Author(s)
      土屋雄一朗
    • Journal Title

      バイオサイエンスとインダストリー (B&I)

      Volume: 77 Pages: 299-303

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica.2018

    • Author(s)
      Uraguchi, D., Kuwata, K., Hijikata, Y., Yamaguchi, R., Imaizumi, H., Am, S., Rakers, C., Mori, N., Akiyama, K., Irle, S., McCourt, P., Kinoshita, T., Ooi, T., and Tsuchiya, Y.
    • Journal Title

      Science

      Volume: 362 Issue: 6420 Pages: 1301-1305

    • DOI

      10.1126/science.aau5445

    • NAID

      120006623828

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small Molecule Toolbox for Strigolactone Biology2018

    • Author(s)
      Tsuchiya Yuichiro
    • Journal Title

      Plant and Cell Physiology

      Volume: 59 Issue: 8 Pages: 1511-1519

    • DOI

      10.1093/pcp/pcy119

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dynamics of strigolactone perception in Striga hermonthica: a working hypothesis2018

    • Author(s)
      Tsuchiya Yuichiro、Yoshimura Masahiko、Hagihara Shinya
    • Journal Title

      Journal of Experimental Botany

      Volume: 69 Issue: 9 Pages: 2281-2290

    • DOI

      10.1093/jxb/ery061

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Manipulating strigolactone receptors in parasitic plant Striga hermonthica with small molecules2020

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      MBS symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 寄生植物ストライガの撲滅に 向けたケミカルバイオロジー研究2019

    • Author(s)
      土屋雄一朗
    • Organizer
      植物化学調節会議
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Unravel strigolactone signaling and controlling parasitic plant behaviors with small molecules2019

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      International conference on plant growth substances
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unravel strigolactone signaling and controlling parasitic plant behaviors with small molecules2019

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      International Parasitic Plant Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unravel strigolactone signaling and controlling parasitic plant behaviors2019

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      ACS Spring
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unravel strigolactone signaling and controlling parasitic plant behaviors with small molecules2019

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      CSH meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 寄生植物ストライガの撲滅に向けたケミカルバイオロジー研究2019

    • Author(s)
      土屋雄一朗
    • Organizer
      植物科学シンポジウム2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Unravel strigolactone signaling and controlling parasitic plant behaviors2019

    • Author(s)
      Yuichiro Tsuchiya
    • Organizer
      ACS Spring 2019
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.itbm.nagoya-u.ac.jp/en/research/2018/12/Striga-SPL7.php

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 寄生植物発芽調節剤2018

    • Inventor(s)
      土屋雄一朗、浦口大輔、大井貴史、木下俊則、望田啓子
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
    • Overseas

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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