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Integration of nutrient and microbial cues in the regulation of plant immunity

Research Project

Project/Area Number 18H02467
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44030:Plant molecular biology and physiology-related
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Saijo Yusuke  奈良先端科学技術大学院大学, 先端科学技術研究科, 教授 (50587764)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords植物微生物相互作用 / 植物免疫 / 共生 / 環境応答 / 土壌栄養 / 貧栄養 / マイクロバイオーム / リン / PSR / 微生物 / シグナル伝達 / 受容体 / 栄養 / 環境適応
Outline of Final Research Achievements

This project aims at a better understanding of the mechanisms by which plants integrate microbial and nutritional cues to finetune their immune responses to pathogenic and mutualistic microbes. We show that defense activation through damage-inducible Pep peptides is sensitized under phosphate deficiency, thereby conferring pathogen resistance while accommodating mutualistic microbes for nutrition. Our investigation into the molecular links between immune and phosphate starvation response (PSR) pathways reveals a key role played by PMR4 callose synthase in root callose deposition and phosphate acquisition during PSR. Moreover, genetic studies on PSR pathways via PHR1/PHL1 transcription factors and LPR1/LPR2 ferroxydases further show their critical role in the control of root-associated microbiomes even under nutrient sufficiency. These findings give novel mechanistic insight into the emerging linkage between plant immunity and nutrition deficiency responses.

Academic Significance and Societal Importance of the Research Achievements

植物と微生物の関係性は環境条件に応じて大きく変わるものの、背景にある分子機構の解明は遅れている。共生菌に依存する低リン条件における免疫制御機構の解明を進めた本研究は、栄養環境情報にもとづき植物が免疫・共生制御を行う仕組みの解明に先鞭をつけ、国内外で求められている植物・微生物・環境の三者相互作用研究に重要な貢献を果たした。同時に、野外環境で実効性の高い病害抵抗性作物や共生菌制御技術を開発する上で有意義な情報を提供した。本成果は、植物の環境適応機構を活用して、環境変動に耐える頑強な作物の作出や効率的な共生菌・土壌栄養利用を可能にし、持続可能な食料生産システムの構築に貢献するものである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (24 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 10 results)

  • [Int'l Joint Research] CEA-CNRS-AMU(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Montpellier/INRA/CNRS(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] MPIPZ(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] CEA/CNRS(フランス)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Uncoupling root hair formation and defence activation from growth inhibition in response to damage‐associated Pep peptides in Arabidopsis thaliana2020

    • Author(s)
      Okada Kentaro、Kubota Yuki、Hirase Taishi、Otani Koichi、Goh Tatsuaki、Hiruma Kei、Saijo Yusuke
    • Journal Title

      New Phytologist

      Volume: 229 Issue: 5 Pages: 2844-2858

    • DOI

      10.1111/nph.17064

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Phosphorylation Dynamics Under Carbon/Nitrogen-Nutrient Stress and Identification of a Cell Death-Related Receptor-Like Kinase in Arabidopsis2020

    • Author(s)
      Li Xingwen、Sanagi Miho、Lu Yu、Nomura Yuko、Stolze Sara Christina、Yasuda Shigetaka、Saijo Yusuke、Schulze Waltraud X.、Feil Regina、Stitt Mark、Lunn John E.、Nakagami Hirofumi、Sato Takeo、Yamaguchi Junji
    • Journal Title

      Frontiers in Plant Science

      Volume: 11 Pages: 377-377

    • DOI

      10.3389/fpls.2020.00377

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana2020

    • Author(s)
      Yoshiyama Kaoru Okamoto、Aoshima Naoki、Takahashi Naoki、Sakamoto Tomoaki、Hiruma Kei、Saijo Yusuke、Hidema Jun、Umeda Masaaki、Kimura Seisuke
    • Journal Title

      Plant Molecular Biology

      Volume: 103 Issue: 3 Pages: 321-340

    • DOI

      10.1007/s11103-020-00994-0

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plant immunity in signal integration between biotic and abiotic stress responses.2020

    • Author(s)
      Saijo Y, Loo EP.
    • Journal Title

      New Phytologist

      Volume: 225 Issue: 1 Pages: 87-104

    • DOI

      10.1111/nph.15989

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pattern recognition receptors confer plant salt tolerance via WRKY18/WRKY40 transcription factors2020

    • Author(s)
      Eliza P. Loo, Yuri Tajima, Kohji Yamada, Taishi Hirase, Hirotaka Ariga, Tadashi Fujiwara, Keisuke Tanaka, Teruaki Taji, Imre E. Somssich, Jane E. Parker, Yusuke Saijo
    • Journal Title

      bioRxiv

      Volume: 2020

    • DOI

      10.1101/2020.05.07.082172

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Integration of danger peptide signals with HAMP signaling amplifies the anti-herbivore defense responses in rice2018

    • Author(s)
      Shinya Tomonori、Yasuda Shigetaka、Hyodo Kiwamu、Tani Rena、Hojo Yuko、Fujiwara Yuka、Hiruma Kei、Ishizaki Takuma、Fujita Yasunari、Saijo Yusuke、Galis Ivan
    • Journal Title

      Plant Journal

      Volume: 印刷中 Issue: 4 Pages: 626-637

    • DOI

      10.1111/tpj.13883

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis.2018

    • Author(s)
      Ogita N, Okushima Y, Tokizawa M, Yamamoto YY, Tanaka M, Seki M, Makita Y, Matsui M, Okamoto-Yoshiyama K, Sakamoto T, Kurata T, Hiruma K, Saijo Y, Takahashi N, Umeda M.
    • Journal Title

      The Plant Journal

      Volume: - Issue: 3 Pages: 439-453

    • DOI

      10.1111/tpj.13866

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pattern recognition receptors and signaling in plant-microbe interactions.2018

    • Author(s)
      Saijo Y, Loo EP, and Yasuda S.
    • Journal Title

      Plant J

      Volume: 93 Issue: 4 Pages: 592-613

    • DOI

      10.1111/tpj.13808

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Callose synthase-mediated adaptation to phosphate starvation in Arabidopsis thaliana2021

    • Author(s)
      Kentaro Okada, Koei Yachi, Nhi Nguyen tan Anh, Tae-Hong Lee, Satomi Kanno, Kei Hiruma, Yusuke Saijo
    • Organizer
      第62回日本植物生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Microbiome regulation by phosphorus starvation response regulators in Arabidopsis thaliana2021

    • Author(s)
      Ryo Chigusa, Ayato Hirano, Kentaro Okada, Yuniar Devi Utami, Kei Hiruma, Miki Fujita and Yusuke Saijo
    • Organizer
      第62回日本植物生理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Pattern recognition receptors mediate direct apoplastic resistance against bacterial water acquisition in plants2019

    • Author(s)
      Yusuke Saijo
    • Organizer
      The 30th International Conference on Arabidopsis Research,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pattern recognition receptors confer direct apoplastic resistance against bacterial water acquisition in plants.2019

    • Author(s)
      Yusuke Saijo
    • Organizer
      International Symposium on Plant Receptor Kinases and Cell Signaling 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phosphate status-dependent control of associations with beneficial and pathogenic fungi in Arabidopsis thaliana2019

    • Author(s)
      Tae-Hong Lee, Takuma Inoue, Midori Tanaka, Taishi Hirase, Shigetaka Yasuda, Kei Hiruma and Yusuke Saijo
    • Organizer
      2019 IS-MPMI XVIII Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pattern-triggered immunity under water stress conditions2019

    • Author(s)
      Yusuke Saijo
    • Organizer
      Japan-Taiwan Plant Biology 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pattern recognition receptors in fluctuating environments2018

    • Author(s)
      Lee T, Loo EP, Tanaka M, Tajima Y, Hirase T, Yamada K, Yasuda S, Hiruma K and Saijo Y.
    • Organizer
      International Plant Molecular Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 微生物の認識と制御を介した植物の環境適応2018

    • Author(s)
      西條雄介
    • Organizer
      第53回感染生理談話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] リン栄養環境情報に基づく植物免疫の制御2018

    • Author(s)
      西條雄介
    • Organizer
      第4回植物栄養研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 微生物情報と環境情報の統合に基づく植物免疫の制御と環境適応2018

    • Author(s)
      西條雄介
    • Organizer
      第28回植物微生物研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 植物のパターン認識受容体を介した微生物の認識・制御と環境適応2018

    • Author(s)
      西條雄介
    • Organizer
      日本育種学会平成30年度秋季大会ワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Integration of microbial and environmental cues in plant immunity2018

    • Author(s)
      Yusuke Saijo
    • Organizer
      ICPS (EIG-CENCERT) symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2024-01-30  

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