| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
The mechanism of sexual differentiation of the external genitalia, which is regulated by the hormonal environment, remains unclear. In this study, we identified that several parameters that prescribe hormone-dependent development and morphology of external genitalia by computed tomography (CT) scan analysis, and were able to quantitatively evaluate the phenotype of the mouse external genitalia. In addition, gene expression in the fetal external genitalia was analyzed by RNA sequencing, and identified several differential expression genes (DEGs) which gene expression depends on hormonal environment during embryonic development. The results provide a basis for accurate evaluation of the degree of sexual differentiation between males and females at the genetic level.
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