Exploring factors that drive sexual differentiation of external genitalia
Project/Area Number |
18H02474
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 44040:Morphology and anatomical structure-related
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Research Institution | Tokyo University of Science |
Principal Investigator |
MIYAGAWA SHINICHI 東京理科大学, 基礎工学部生物工学科, 准教授 (30404354)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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Keywords | 外生殖器 / アンドロゲン / 性分化 / マウス / 生殖器 / 発生 / ホルモン / 遺伝子発現 |
Outline of Final Research Achievements |
The mechanism of sexual differentiation of the external genitalia, which is regulated by the hormonal environment, remains unclear. In this study, we identified that several parameters that prescribe hormone-dependent development and morphology of external genitalia by computed tomography (CT) scan analysis, and were able to quantitatively evaluate the phenotype of the mouse external genitalia. In addition, gene expression in the fetal external genitalia was analyzed by RNA sequencing, and identified several differential expression genes (DEGs) which gene expression depends on hormonal environment during embryonic development. The results provide a basis for accurate evaluation of the degree of sexual differentiation between males and females at the genetic level.
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Academic Significance and Societal Importance of the Research Achievements |
尿道下裂の発症頻度は1/200-1/300とされ、非常に頻度の高い先天性疾患である。新生児期の外性器異常は、社会的な性の決定に関わる大きな問題であることから、正確な医学的評価と根拠を要する。本研究によって得られる知見は、生殖器系に係わる診断技術や治療などの医療行為を実践するための基本的知識を提供すると共に、これら先天性疾患の原因解明の基礎となることが期待される。本研究によって推進される性分化や疾患に対する理解は、性の多様性の理解にもつながる。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice.2019
Author(s)
Acebedo AR, Suzuki K, Hino S, Alcantara MC, Sato Y, Haga H, Matsumoto KI, Nakao M, Shimamura K, Takeo T, Nakagata N, Miyagawa S, Nishinakamura R, Adelstein RS, Yamada G.
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Journal Title
Commun. Biol.
Volume: eCollection
Issue: 1
Pages: 95-95
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk Factors for Hypospadias.2019
Author(s)
Kojima Y, Koguchi T, Mizuno K, Sato Y, Hoshi S, Hata J, Nishio H, Hashimoto D, Matsushita S, Suzuki K, Miyagawa S, Hui CC, Tanikawa C, Murakami Y, Yamada G, Hayashi Y, Matsuda K.
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Journal Title
J Urol.
Volume: 201(2)
Issue: 2
Pages: 386-392
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR.2018
Author(s)
Ogino Y, Tohyama S, Kohno S, Toyota K, Yamada G, Yatsu R, Kobayashi T, Tatarazako N, Sato T, Matsubara H, Lange A, Tyler CR, Katsu Y, Iguchi T, Miyagawa S.
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Journal Title
J Steroid Biochem Mol Biol.
Volume: 184
Pages: 38-46
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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