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Study on molecular/neural basis underlying face recognition in medaka fish

Research Project

Project/Area Number 18H02479
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionTohoku University (2019-2020)
Okayama University (2018)

Principal Investigator

TAKEUCHI Hideaki  東北大学, 生命科学研究科, 教授 (00376534)

Co-Investigator(Kenkyū-buntansha) 王 牧芸  東京大学, 大学院総合文化研究科, 特任研究員 (70781152)
横井 佐織  北海道大学, 薬学研究院, 助教 (10772048)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsソーシャルビジョン / 上丘 / 顔認知 / オキシトシン / 視蓋 / パリウム / Tet-ONシステム / 顔領域 / 最初期遺伝子 / クローナルユニット / ソーシャルサリエンス仮説 / 小型魚類 / 社会認知 / 魚類
Outline of Final Research Achievements

Medaka fish have visual ability to discriminate between familiar/unfamiliar mates. We found that the oxytocin signaling pathway (oxt-oxtr1) is required for the mate preference for familiar conspecifics in both sexes. This pathway is essential for eliciting female mate preference for familiar males, while it is also required for the unrestricted and indiscriminate preference of males. Next, we showed that oxtr1 (oxytocin receptor) was expressed in the primary visual center (optic tectum), which is a homolog to the mammalian superior colliculus (SC). Interestingly, primate oxtr is also expressed in the SC and the SC is involved in infant monkeys' rapid and innate face detection. Thus the optic tectum is one of the candidates for brain regions for face detection in medaka fish. In addition, we revealed that visual stimuli from conspecifics activated one brain region (Vd) in the pallium. To identify gene markers for this brain region, we conducted RNA-seq made a gene expression profile.

Academic Significance and Societal Importance of the Research Achievements

これまで顔認知に関わる神経機構は霊長類で固有に進化したと信じられており、魚類に着目した研究はなかった。霊長類研究では遺伝子操作が困難であることから、顔認知の分子神経基盤の解明は進んでいない。本研究課題では、メダカの顔認知に関わる脳領域候補を同定し、機能解析に必要なマーカー遺伝子の同定や遺伝子発現制御ツール(Tet-ON)システムの確立に成功した。これにより、世界に先駆けて動物の顔認知に関わる分子神経基盤をシンプルな実験動物を用いて解析できるようになった。また霊長類と比較可能な脳領域(視蓋・上丘)に着目することで、メダカ の基礎研究がヒトの先天的な顔認知機構の原型の発見につながる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Book (3 results) Remarks (4 results)

  • [Int'l Joint Research] エモリー大学(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] エモリー大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Emory University(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Sexually dimorphic role of oxytocin in medaka mate choice2020

    • Author(s)
      Yokoi Saori、Naruse Kiyoshi、Kamei Yasuhiro、Ansai Satoshi、Kinoshita Masato、Mito Mari、Iwasaki Shintaro、Inoue Shuntaro、Okuyama Teruhiro、Nakagawa Shinichi、Young Larry J.、Takeuchi Hideaki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 9 Pages: 4802-4808

    • DOI

      10.1073/pnas.1921446117

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of omnidirectional aerial display with aerial imaging by retro-reflection (AIRR) for behavioral biology experiments2019

    • Author(s)
      Abe Erina、Yasugi Masaki、Takeuchi Hideaki、Watanabe Eiji、Kamei Yasuhiro、Yamamoto Hirotsugu
    • Journal Title

      Optical Review

      Volume: 26 Issue: 1 Pages: 221-229

    • DOI

      10.1007/s10043-019-00502-w

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] メダカの個体認知を介した配偶者選択に関わる脳の分子神経基盤2021

    • Author(s)
      竹内 秀明
    • Organizer
      日本化学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳行動状態系が社会行動選択にバイアスを与える分子神経機構の解明-メダカを動物モデルとして-2020

    • Author(s)
      竹内秀明
    • Organizer
      NPBPPP
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 性的パートナー選択にバイアスを与える脳の内部状態の神経基盤2019

    • Author(s)
      竹内秀明
    • Organizer
      日本認知学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Individual recognition in medaka fish2018

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      4rd Medaka Strategic Meeting, Heidelberg, Germany
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Social peptides in medaka fish2018

    • Author(s)
      Hideaki Takeuchi
    • Organizer
      International workshop on “UNDERSTANDING THE NEUROREGULATORY ACTIONS OF OXYTOCIN AND ITS POTENTIAL CLINICAL APPLICATIONS”, ERICE, Italy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 生物の科学「遺伝」メダカの個体認知能力と配偶者選択2018

    • Author(s)
      王牧芸、横井佐織、奥山輝大、 竹内秀明
    • Total Pages
      7
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436360
    • Related Report
      2018 Annual Research Report
  • [Book] 生物の科学「遺伝」メダカの行動学研究の最先端~メダカはなぜ豊かな色彩を持つのか?2018

    • Author(s)
      竹内秀明、深町昌司、亀井保博、成瀬清
    • Total Pages
      3
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436360
    • Related Report
      2018 Annual Research Report
  • [Book] 生物の科学[遺伝」「約100年継承された伝統系統メダカ」2018

    • Author(s)
      竹内秀明
    • Total Pages
      7
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436360
    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科脳生命統御学専攻 分子行動分野

    • URL

      https://sites.google.com/view/molecular-ethology-laboratory

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/Takeuchi

    • Related Report
      2020 Annual Research Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/Takeuchi/published_papers/4386471

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東北大学大学院生命科学研究科脳生命統御学専攻分子行動分野

    • URL

      https://sites.google.com/view/molecular-ethology-laboratory

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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