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Investigation of vertebrate brain photoreception and its diversity by characterizing non-visual photoreceptor proteins

Research Project

Project/Area Number 18H02482
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionOsaka City University

Principal Investigator

Koyanagi Mitsumasa  大阪市立大学, 大学院理学研究科, 教授 (30379276)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords光生物学 / 眼外光受容 / ロドプシン / GPCR / 光生物 / 脳
Outline of Final Research Achievements

Animals utilize light for vision and non-visual functions. Recently, direct brain photoreception has been a hot topic in life sciences. In this study, we showed that photoreceptor proteins expressed in brains indeed serve as light-sensors. In addition, our investigation of the brain photoreceptor proteins of varied animals revealed their spectral sensitivities and signal transduction pathways, which uncovered molecular mechanisms of vertebrate brain photoreception and its diversity.

Academic Significance and Societal Importance of the Research Achievements

近年、動物の光利用において、視覚以外の役割に関心が集まっている。中でも、脳の直接的な光受容は特に注目されているため、本研究で初めて明らかにした、脳内光受容タンパク質の分子レベルの性質や光情報の伝達に関する知見の学術的意義は大きく、今後の脳内光受容の全容解明に大きく貢献することが期待できる。また、従来、脳での光受容が認められていなかった哺乳類においても脳内光受容タンパク質の解析が進んだことは、ヒトに存在する未知の脳機能を知る手掛かりとなり得ることから、社会的意義や関心も高いと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (122 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (16 results) Journal Article (12 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Open Access: 11 results) Presentation (91 results) (of which Int'l Joint Research: 14 results,  Invited: 11 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institute(スイス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Institut de la Vision(フランス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] The University of Toledo(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institute(スイス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Institut de la Vision(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] The University of Toledo(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institute(スイス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Institut de la Vision(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] The University of Toledo/Salk Institute for Biological Studies(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] The University of Manchester(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Paul Scherrer Institute(スイス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institut de la Vision(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] The University of Toledo/Salk Institute for Biological Studies(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey2021

    • Author(s)
      Wada Seiji、Kawano-Yamashita Emi、Sugihara Tomohiro、Tamotsu Satoshi、Koyanagi Mitsumasa、Terakita Akihisa
    • Journal Title

      BMC Biology

      Volume: 19 Issue: 1 Pages: 188

    • DOI

      10.1186/s12915-021-01121-1

    • NAID

      120007149260

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019688

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish2021

    • Author(s)
      Baoguo Shen, Seiji Wada, Haruka Nishioka, Takashi Nagata, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
    • Journal Title

      Zoological letters

      Volume: 7(1) Issue: 1 Pages: 1-1

    • DOI

      10.1186/s40851-021-00171-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visual and nonvisual opsin genes of sharks and other nonosteichthyan vertebrates: Genomic exploration of underwater photoreception2020

    • Author(s)
      Kazuaki Yamaguchi, Mitsumasa Koyanagi, Shigehiro Kuraku
    • Journal Title

      Journal of evolutionary biology

      Volume: - Issue: 6 Pages: 968-976

    • DOI

      10.1111/jeb.13730

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] From extraocular photoreception to pigment movement regulation: a new control mechanism of the lanternshark luminescence2020

    • Author(s)
      Laurent Duchatelet, Tomohiro Sugihara, Jerome Delroisse, Mitsumasa Koyanagi, Rene Rezsohazy, Akihisa Terakita, Jerome Mallefet
    • Journal Title

      Scientific reports

      Volume: 10 Issue: 1 Pages: 10195

    • DOI

      10.1038/s41598-020-67287-w

    • NAID

      120006866802

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020481

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The non-visual opsins expressed in deep brain neurons projecting to the retina in lampreys2020

    • Author(s)
      Emi Kawano-Yamashita, Mitsumasa Koyanagi, Seiji Wada, Tomoka Saito, Tomohiro Sugihara, Satoshi Tamotsu, Akihisa Terakita
    • Journal Title

      Scientific reports

      Volume: 10 Issue: 1 Pages: 9669

    • DOI

      10.1038/s41598-020-66679-2

    • NAID

      120006866803

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020480

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spectral tuning mediated by helix III in butterfly long wavelength-sensitive visual opsins revealed by heterologous action spectroscopy.2019

    • Author(s)
      Saito T, Koyanagi M, Sugihara T, Nagata T, Arikawa K, Terakita A
    • Journal Title

      Zoological letters

      Volume: 5 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s40851-019-0150-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-expression of opsins in the eye photoreceptors of the terrestrial slug Limax valentianus.2019

    • Author(s)
      *Matsuo R, Koyanagi M, Nagata A, and Matsuo Y
    • Journal Title

      J Comp Neurol

      Volume: 527 Issue: 18 Pages: 3073-3086

    • DOI

      10.1002/cne.24732

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The counterion-retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation2019

    • Author(s)
      Nagata Takashi, Koyanagi Mitsumasa, Tsukamoto Hisao, Mutt Eshita, Schertler Gebhard F. X., Deupi Xavier, Terakita Akihisa
    • Journal Title

      COMMUNICATIONS BIOLOGY

      Volume: 2 Issue: 1 Pages: 180-180

    • DOI

      10.1038/s42003-019-0409-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Two-Photon Reversible Reaction of the Bistable Jumping Spider Rhodopsin-12019

    • Author(s)
      Ehrenberg David、Varma Niranjan、Deupi Xavier、Koyanagi Mitsumasa、Terakita Akihisa、Schertler Gebhard F.X.、Heberle Joachim、Lesca Elena
    • Journal Title

      Biophysical Journal

      Volume: 116 Issue: 7 Pages: 1248-1258

    • DOI

      10.1016/j.bpj.2019.02.025

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Color opponency with a single kind of bistable opsin in the zebrafish pineal organ2018

    • Author(s)
      Wada Seiji、Shen Baoguo、Kawano-Yamashita Emi、Nagata Takashi、Hibi Masahiko、Tamotsu Satoshi、Koyanagi Mitsumasa、Terakita Akihisa
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 44 Pages: 11310-11315

    • DOI

      10.1073/pnas.1802592115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates2018

    • Author(s)
      Hara Yuichiro、Yamaguchi Kazuaki、Onimaru Koh、Kadota Mitsutaka、Koyanagi Mitsumasa、Keeley Sean D.、Tatsumi Kaori、Tanaka Kaori、Motone Fumio、Kageyama Yuka、Nozu Ryo、Adachi Noritaka、Nishimura Osamu、Nakagawa Reiko、Tanegashima Chiharu、Kiyatake Itsuki、Matsumoto Rui、Murakumo Kiyomi、Nishida Kiyonori et al.
    • Journal Title

      Nature Ecology & Evolution

      Volume: 2 Issue: 11 Pages: 1761-1771

    • DOI

      10.1038/s41559-018-0673-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish2018

    • Author(s)
      Gerrard Elliot、Mutt Eshita、Nagata Takashi、Koyanagi Mitsumasa、Flock Tilman、Lesca Elena、Schertler Gebhard F. X.、Terakita Akihisa、Deupi Xavier、Lucas Robert J.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 24 Pages: 201721333

    • DOI

      10.1073/pnas.1721333115

    • NAID

      120006474983

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020448

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 非視覚オプシンの解析のための選択的活性化法の開発2021

    • Author(s)
      岩崎 誠, 和田清二, 永田崇, 杉原智博, 小柳光正, 寺北明久
    • Organizer
      日本動物学会 近畿支部 研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 造礁サンゴがもつ多様なオプシン類の光受容特性の解析2021

    • Author(s)
      酒井祐輔, 小柳光正, 寺北明久
    • Organizer
      日本動物学会 近畿支部 研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 有袋類の非視覚オプシンに着目した哺乳類の光受容の変遷2021

    • Author(s)
      小柳光正, 高草大悟, 清成寛
    • Organizer
      日本進化学会第23回東京大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 深海での光受容に特化したジンベエザメの視覚2021

    • Author(s)
      山口和晃, 小柳光正, 佐藤圭一, 寺北明久, 工樂樹洋
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オプシン欠損変異体を用いたゼブラフィッシュ松果体光応答の解析2021

    • Author(s)
      和田清二, 小柳光正, 寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 原始的な多細胞動物に存在するオプシン様GPCRの解析2021

    • Author(s)
      髙橋直樹, 寺北明久, 小柳光正
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 非視覚オプシンゼブラフィッシュOpn3のGタンパク質活性化能の解析2021

    • Author(s)
      白田泰士, 杉原智博, 永田崇, 小柳光正, 寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ゼブラフィッシュ網膜におけるメラノプシン発現水平細胞の光に対する応答の解析2021

    • Author(s)
      真野桃歌, 和田清二, 小柳光正, 寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ハエトリグモのユニークな奥行き知覚メカニズムを支えるロドプシンの吸収極大波長制御機構の解析????2021

    • Author(s)
      佐藤龍, 永田崇, 寺北明久, 小柳光正
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 哺乳類の非視覚オプシンOpn3の分子特性の解析2021

    • Author(s)
      高草大悟, 杉原智博, 寺北明久, 小柳光正
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 松果体オプシン、パラピノプシン変異ゼブラフィッシュを用いた光依存的な行動の解析2021

    • Author(s)
      山本悠貴, 斉藤智香, 和田清二, 小柳光正, 寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 造礁性のウスエダミドリイシがもつ多様なオプシン類の光受容特性の解析.2021

    • Author(s)
      酒井祐輔, 塚本寿夫, 小柳光正, 寺北明久
    • Organizer
      日本動物学会第92回オンライン米子大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Five opsins sensitive to blue to green lights are co-expressed in the eye photoreceptors of the terrestrial slug Limax2021

    • Author(s)
      Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Yuko Matsuo, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Transmission of light information generated in the pineal organ to the midbrain in zebrafish.2021

    • Author(s)
      Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Molecular roperties of opsin-like GPCRs identified in a primitive multicellular animal2021

    • Author(s)
      Naoki Takahashi, Akihisa Terakita, Mitsumasa Koyanagi
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Comparative investigation of G protein activation ability of a non-visual opsin, zebrafish Opn32021

    • Author(s)
      Taishi Shirata, Tomohiro Sugihara, Takashi Nagata, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A possible regulation of cone light responses by melanopsin distributed to horizontal cells in the larval zebrafish2021

    • Author(s)
      Momoka Mano, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Toward detection of neural activity changes in the zebrafish brain derived from extraocular photoreceptions.2021

    • Author(s)
      Yuya Namikoshi, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Spectroscopic characterization of anthozoa-specific opsins found in a reef-building coral.2021

    • Author(s)
      Yusuke Sakai, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第43回札幌大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 奥行き知覚を支えるハエトリグモ視物質の特徴的な吸収スペクトルの獲得2020

    • Author(s)
      小柳光正、永田崇、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゼブラフィッシュにおける松果体光情報の処理に関わる脳部位候補の解析2020

    • Author(s)
      和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゼブラフィッシュにおける松果体光応答:「色検出」とその脳投射2020

    • Author(s)
      和田清二、沈宝國、山下(川野)絵美、永田崇、日比正彦、保智己、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュ松果体の色検出を担う光受容タンパク質の不活性化機構の解析2020

    • Author(s)
      沈宝国、和田清二、西岡春香、杉原智博、永田崇、橘木修志、山下(川野)絵美、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゼブラフィッシュ網膜におけるメラノプシンの視覚への関与に関する解析2020

    • Author(s)
      真野桃歌、和田清二、小柳光正、寺北明久
    • Organizer
      日本動物学会第91回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Investigation of opsins in the reef-building coral, Acropora tenuis, exhibiting a light-response behavior at the larval stage2020

    • Author(s)
      Yusuke Sakai, Hisao Tsukamoto, Naoto Ueno, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Functional analysis of melaonpsin expressed in retinal horizontal cells of zebrafish2020

    • Author(s)
      真野桃歌、和田清二、小柳光正、寺北明久
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Investigation of opsin-like GPCRs identified in a primitive multicellular animal.2020

    • Author(s)
      髙橋直樹、寺北明久、小柳光正
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Comparative investigation of G protein activation ability of members of a non-visual opsin, Opsin3 group.2020

    • Author(s)
      Taishi Shirata, Tomohiro Sugihara, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Toward a new method for selective activation of a non-visual opsin2020

    • Author(s)
      Makoto Iwasaki, Tomohiro Sugihara, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      42nd Annual Meeting of The Japanese Society for Comparative Physiology and Biochemistry
    • Related Report
      2020 Annual Research Report
  • [Presentation] Histological investigation of deep brain photoreceptors in the larval and adult lampreys2020

    • Author(s)
      Emi Kawano-Yamashita, Nanaho Yura, Mitsumasa Koyanagi, Seiji Wada, Akihisa Terakita, Satoshi Tamotsu
    • Organizer
      日本比較生理生化学会第42回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 奥行き知覚を支えるハエトリグモのロドプシンの分子進化2020

    • Author(s)
      小柳光正、永田崇、寺北明久
    • Organizer
      日本進化学会第22回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 造礁サンゴAcropora tenuisの幼生における光応答的な遊泳行動と成体の分布パターンへの影響2020

    • Author(s)
      酒井祐輔、加藤輝、小山宏史、Alyson Kuba、高橋弘樹、藤森俊彦、服田昌之、Andrew Negri、Andrew Baird、上野直人
    • Organizer
      日本進化学会第22回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Jumping spider Rh-1 as a possible model of bistable rhodopsins for structural, functional and optogenetic studies2020

    • Author(s)
      Akihisa Terakita, Mitsumasa Koyanagi, Tomohiro Sugihara, Takashi Nagata
    • Organizer
      CREST「光の特性を活用した生命機能の時空間制御技術の開発と応用」第4回領域会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] 動物の視覚光センサータンパク質・ロドプシンにおける発色団のプロトン化に関する変異体解析2020

    • Author(s)
      永田 崇,小柳 光正,塚本 寿夫,Eshita Mutt,Gebhard F. X. Schertler,Xavier Deupi,寺北明久
    • Organizer
      物性研短期研究会「理論タンパク質物性科学の最前線:理論と実験との密な協働」
    • Related Report
      2019 Annual Research Report
  • [Presentation] Chromatic response with a single kind of opsin in the zebrafish pineal organ2019

    • Author(s)
      Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      FASEB SRC The Biology & Chemistry of Vision
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spectral tuning in butterfly long wavelength-sensitive visual opsins2019

    • Author(s)
      Tomoka Saito, Mitsumasa Koyanagi, Tomohiro Sugihara, Takashi Nagata, Kentaro Arikawa, Akihisa Terakita
    • Organizer
      FASEB SRC The Biology & Chemistry of Vision
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オプシンファミリーに近縁なGPCRに着目したオプシンの起源の探索2019

    • Author(s)
      小柳 光正,高橋 直樹,寺北 明久
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Color dependent light regulation of cell responses by a non-visual bistable opsin parapinopsin2019

    • Author(s)
      Mitsumasa Koyanagi, Seiji Wada, Baoguo Shen, Takashi Nagata, Akihisa Terakita
    • Organizer
      2019 ESP-IUPB World Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 無脊椎動物視覚ロドプシンにおける対イオン-プロトン化シッフ塩基間相互作用の変異体解析2019

    • Author(s)
      永田 崇,小柳 光正,塚本 寿夫,Eshita Mutt,Gebhard F. X. Schertler,Xavier Deupi,寺北 明久
    • Organizer
      ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハエトリグモの視物質の吸収スペクトルと奥行き知覚メカニズムの進化との関係2019

    • Author(s)
      小柳 光正,永田 崇,斉藤 智香,寺北 明久
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 無顎類ヤツメウナギの脳深部に存在する新規光受容器官の非視覚オプシンに着目した組織学的解析2019

    • Author(s)
      山下(川野) 絵美,由良 南々帆,小柳 光正,和田 清二,寺北 明久,保 智己
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] サメのゲノム配列から明らかとなった生息水深への視覚の適応2019

    • Author(s)
      山口 和晃,小柳 光正,原 雄一郎,野津 了,佐藤 圭一,寺北 明久,工樂 樹洋
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゼブラフィッシュ松果体における波長検出に関わる光受容タンパク質パラピノプシンの不活性化機構の解析2019

    • Author(s)
      沈 宝国,和田 清二,永田 崇,山下(川野) 絵美,小柳 光正,寺北 明久
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゼブラフィッシュにおいて松果体光受容タンパク質が関わる光点灯時の遊泳活性の制御2019

    • Author(s)
      中田 玄樹,和田 清二,小柳 光正,寺北 明久
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゼブラフィッシュ松果体における非感色性光応答を担う光受容タンパク質の解析2019

    • Author(s)
      和田 清二,沈 宝國,山下(川野) 絵美,永田 崇,日比 正彦,保 智己,小柳 光正,寺北 明久
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゼブラフィッシュ松果体における色情報検出を担う光受容体2019

    • Author(s)
      和田 清二,沈 宝國,山下(川野) 絵美,永田 崇,日比 正彦,保 智己,小柳 光正,寺北 明久
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動物の双安定型ロドプシンを用いた細胞内シグナル伝達の光操作2019

    • Author(s)
      小柳 光正
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Light regulation of cell responses by animal rhodopsins2019

    • Author(s)
      Mitsumasa Koyanagi
    • Organizer
      9th Asia and Oceania Conference on Photobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 動物の光受容タンパク質の解析から生態・進化を探る2019

    • Author(s)
      小柳 光正
    • Organizer
      第四回軟骨魚類研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 松果体におけるオプシンの分子特性と波長識別2019

    • Author(s)
      和田 清二,沈 宝國,山下(川野) 絵美,永田 崇,日比 正彦,保 智己,小柳 光正,寺北 明久
    • Organizer
      基礎生物学研究所セミナー「異分野融合による次世代光生物学研究会」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 動物のオプシンの起源の探索2019

    • Author(s)
      小柳 光正,高橋 直樹,寺北 明久
    • Organizer
      基礎生物学研究所セミナー「異分野融合による次世代光生物学研究会」
    • Related Report
      2019 Annual Research Report
  • [Presentation] 板鰓類のゲノム解析:「サメらしさ」に分子から迫る2019

    • Author(s)
      工樂 樹洋,原 雄一郎,山口 和晃,野津 了,小柳 光正,寺北 明久,喜屋 武樹,西田 清徳,兵藤 晋,佐藤 圭一
    • Organizer
      基礎生物学研究所セミナー「異分野融合による次世代光生物学研究会」
    • Related Report
      2019 Annual Research Report
  • [Presentation] サメを知らずに脊椎動物を語れるかーゲノムから視覚を探る2019

    • Author(s)
      工樂 樹洋,山口 和晃,小柳 光正,寺北 明久
    • Organizer
      基礎生物学研究所セミナー「異分野融合による次世代光生物学研究会」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A signaling pathway of “color information” generated in parapinopsin-expressing pineal photoreceptor cells to brain neurons in zebrafish2019

    • Author(s)
      Seiji Wada, Baoguo Shen, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第41回東京大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Optical regulation of intracellular signaling using bistable animal opsins2019

    • Author(s)
      Mitsumasa Koyanagi, Seiji Wada, Baoguo Shen, Takashi Nagata, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第41回東京大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evaluating contribution of pineal opsin, parapinopsin-based color opponency to preference for dark and light in zebrafish larvae2019

    • Author(s)
      Tomoka Saito, Seiji Wada, Baoguo Shen, Genki Nakata , Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第41回東京大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 動物の双安定型ロドプシンを用いたGPCRシグナル伝達の光操作2019

    • Author(s)
      小柳 光正
    • Organizer
      Promega Dynamic Connection 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュ松果体の単一オプシンによる色情報検出2019

    • Author(s)
      和田 清二,沈 宝國,山下(川野)絵美,永田 崇, 日比 正彦, 保 智己, 小柳 光正,寺北 明久
    • Organizer
      第13回バイオイメージングフォーラム&基礎生物学研究所重点共同利用 合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Optical regulation of GPCR signalings using bistable animal opsins2019

    • Author(s)
      Mitsumasa Koyanagi
    • Organizer
      1st International Symposium on Interdisciplinary Approaches to Integrative Understanding of Biological Signaling Networks
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal opsins: non-visual functions and optogenetic applications2019

    • Author(s)
      Akihisa Terakita, Mitsumasa Koyanagi
    • Organizer
      10th OCARINA International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A nobel type of opsin with optogenetic potential: animal opsin-based photopigment as a potential dark-active and light-Inactivated G protein-coupled receptor2019

    • Author(s)
      Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita
    • Organizer
      10th OCARINA International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of “color changes” with a single kind of opsin in the zebrafish pineal organ2019

    • Author(s)
      Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiro Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      10th OCARINA International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contribution of parapinopsin molecular property to cellular light responses in the zebrafish pineal organ2019

    • Author(s)
      Baoguo Shen, Seiji Wada, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      10th OCARINA International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the pineal wavelength discrimination based on a pineal-specific opsin parapinopsin in the zebrafish behaviours2019

    • Author(s)
      Tomoka Saito, Seiji wada, Baoguo Shen, Takashi Nagata, Mitsumasa Koyanagi and Akihisa Terakita
    • Organizer
      10th OCARINA International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Behavioral investigation of non-visual photoreception with pineal-specific opsin- knockout zebrafish2019

    • Author(s)
      Genki Nakata, Seiji Wada, Mitsumasa Koyanagi and Akihisa Terakita
    • Organizer
      10th OCARINA International Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 板鰓類3種のゲノム解析:「サメらしさ」に分子から迫る2019

    • Author(s)
      原 雄一郎,山口 和晃,野津 了,小柳 光正,喜屋武 樹,寺北 明久、西田 清徳,兵藤 晋,佐藤 圭一,工樂 樹洋
    • Organizer
      平成31年度日本水産学会春季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 動物の光受容タンパク質の多様性とその活用術2018

    • Author(s)
      小柳 光正
    • Organizer
      大阪大学生命機能研究科研究交流会(FBSコロキウム)189
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 全トランスレチナール結合オプシン・ペロプシンの光不活性化型GPCRとしての性質2018

    • Author(s)
      永田 崇,小柳 光正,Robert Lucas,寺北 明久
    • Organizer
      第20回日本光生物学協会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゼブラフィッシュ松果体における1種類のオプシンに基づく波長検出応答2018

    • Author(s)
      和田 清二,沈 宝國,山下(川野)絵美,永田 崇, 日比 正彦, 保 智己, 小柳 光正,寺北 明久
    • Organizer
      第20回日本光生物学協会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クモのロドプシンの分子進化と奥行き知覚メカニズムの関係2018

    • Author(s)
      小柳 光正,永田 崇,斉藤 智香,寺北 明久
    • Organizer
      日本進化学会第20回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] サメのオプシン遺伝子レパートリーと生息環境との関係を探る2018

    • Author(s)
      山口 和晃,小柳 光正,原 雄一郎,寺北 明久,工樂 樹洋
    • Organizer
      日本進化学会第20回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analyses of pineal photoresponses using opsin-deficient and -replaced zebrafish mutants2018

    • Author(s)
      Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiko Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      第24回小型魚類研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] クモの視物質の吸収スペクトルと奥行き知覚メカニズムの進化との関係2018

    • Author(s)
      小柳 光正,永田 崇,斉藤 智香,前川 優,諏訪 元,寺北 明久
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ゼブラフィッシュ松果体における波長識別を担う光受容体2018

    • Author(s)
      和田 清二,沈 宝國,山下(川野)絵美,永田 崇, 日比 正彦, 保 智己, 小柳 光正,寺北 明久
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 松果体におけるパラピノプシンの寄与する光応答と自然光との関わり2018

    • Author(s)
      和田 清二,沈 宝國,山下(川野)絵美,永田 崇, 日比 正彦, 保 智己, 小柳 光正,寺北 明久
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 遺伝子導入ゼブラフィッシュを用いたオプシンの分子特性が寄与する松果体の光応答の解析2018

    • Author(s)
      沈 宝國,和田 清二,山下(川野)絵美,小柳 光正,寺北 明久
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 幼生期及び成体期のヤツメウナギにおける非視覚オプシンが発現する脳深部光受容器官の組織学的解析2018

    • Author(s)
      山下(川野)絵美,保 智己,小柳 光正,和田 清二,寺北 明久
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] チョウの生殖行動を制御する光受容体2018

    • Author(s)
      塚本 寿夫,内山 博允,秋山 時穂,小柳 光正,古谷 祐詞,寺北 明久,蟻川 謙太郎
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナメクジの視覚機能に関わるオプシンの解析2018

    • Author(s)
      松尾 亮太,小柳 光正,杉原 智博,寺北 明久,西山 春佳,松尾 優子
    • Organizer
      日本動物学会第89回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dark-active and light-inactivated G protein-coupled receptors based on an animal opsin, peropsin2018

    • Author(s)
      Takashi Nagata, Mitsumasa Koyanagi,Robert Lucas and Akihisa Terakita
    • Organizer
      日本生物物理学会第56回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functionality of bistable animal opsins for optogenetic regulation of cellular signal transductions2018

    • Author(s)
      Mitsumasa Koyanagi
    • Organizer
      18th International Conference on Retinal Proteins
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peropsin as a potential light-inactivated G protein-coupled receptor2018

    • Author(s)
      Takashi Nagata, Mitsumasa Koyanagi, Robert Lucas, Akihisa Terakita
    • Organizer
      18th International Conference on Retinal Proteins
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Color opponency with a bistable pigment parapinopsin in the zebrafish pineal organ2018

    • Author(s)
      Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiko Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      18th International Conference on Retinal Proteins
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between absorption spectra of spider rhodopsins and evolution of depth perception mechanism2018

    • Author(s)
      Mitsumasa Koyanagi, Takashi Nagata, Tomoka Saito, Yu Maekawa, Gen Suwa, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Relationship between pineal wavelength discrimination involving parapinopsin and natural light conditions in the zebrafish2018

    • Author(s)
      Seiji Wada, Baoguo Shen, Emi Kawano-Yamashita, Takashi Nagata, Masahiko Hibi, Satoshi Tamotsu, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Comparative investigation of light responses of pineal photoreceptor cells containing different types of opsins with transgenic zebrafish2018

    • Author(s)
      Baoguo Shen, Seiji Wada, Emi Kawano-Yamashita, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Histochemical investigation of phototransduction-related gene expression in zebrafish pineal photoreceptor cells2018

    • Author(s)
      Haruka Nishioka, Takashi Nagata, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Contribution of a pineal opsin to light-suppressed melatonin secretion and light-regulated locomotor activity in zebrafish pineal organ2018

    • Author(s)
      Genki Nakata, Seiji Wada, Mitsumasa Koyanagi, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Histochemical investigation of non-visual opsin-expressing photoreceptor cells in the larval and adult lamprey brains2018

    • Author(s)
      Emi Kawano-Yamashita, Satoshi Tamotsu, Mitsumasa Koyanagi, Seiji Wada, Akihisa Terakita
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Opsins involved in the visual function of the terrestrial slug Limax2018

    • Author(s)
      Ryota Matsuo, Mitsumasa Koyanagi, Tomohiro Sugihara, Akihisa Terakita, Haruka Hishiyama, Yuko Matsuo
    • Organizer
      日本比較生理生化学会第40回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 板鰓類の視覚を司る遺伝子と生息環境の関係を探る2018

    • Author(s)
      山口 和晃,小柳 光正,原 雄一郎,寺北 明久,工樂 樹洋
    • Organizer
      板鰓類シンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Book] Optogenetics2020

    • Author(s)
      Mitsumasa Koyanagi, Tomoka Saito, Seiji Wada, Takashi Nagata, Emi Kawano-Yamashita, Akihisa Terakita
    • Total Pages
      675
    • Publisher
      Springer
    • ISBN
      9789811587634
    • Related Report
      2020 Annual Research Report
  • [Remarks] 大阪公立大学大学院理学研究科生物学専攻 分子生理学研究室

    • URL

      https://www.omu.ac.jp/sci/biol-mphys/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 大阪市立大学大学院理学研究科生物地球系専攻 生体高分子機能学II研究室

    • URL

      http://www.sci.osaka-cu.ac.jp/biol/mphys/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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