Regulation of acclimation rate by whole neural circuit between head and tail
| Project/Area Number |
18H02484
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 45010:Genetics-related
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| Research Institution | Konan University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | C. elegans / カルシウムイメージング / 線虫 / 温度馴化 / 神経回路 / 低温耐性 / 細胞ネットワーク / 低温馴化 / RNAシークエンシング解析 / 温度受容ニューロン |
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| Outline of Final Research Achievements |
We analyzed neural and tissue network regulating temperature response and acclimation by using a neural circuit for temperature acclimation of nematode C. elegans. In this study, we found that aversive chemosensory neuron (ADL) acts as thermosensory neuron, whose activity is modulated by oxygen sensoryneuron via hub interneuron, and that muscle controls ADL activity. Also, mechano sensoryneuron positively and negatively regulates its downstream two interneurons, which affects cold tolerance and acclimation.
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| Academic Significance and Societal Importance of the Research Achievements |
脳は多くのニューロンをもっており、一つ一つのニューロンは繋がり合ってネットワークを構築しているため、神経ネットワークが複雑になるほど、その仕組みの解明には時間がかかる。シンプルな動物の神経ネットワークの解析から、複数の情報を統合する新しい神経回路が見つかった。また、末梢の筋肉が頭部の感覚ニューロンを調節しているケースも見つかった。
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Report
(4 results)
Research Products
(65 results)
