| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We analyzed neural and tissue network regulating temperature response and acclimation by using a neural circuit for temperature acclimation of nematode C. elegans. In this study, we found that aversive chemosensory neuron (ADL) acts as thermosensory neuron, whose activity is modulated by oxygen sensoryneuron via hub interneuron, and that muscle controls ADL activity. Also, mechano sensoryneuron positively and negatively regulates its downstream two interneurons, which affects cold tolerance and acclimation.
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