| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
In this study, we aimed to identify all the major genes involved in wing pigmentation pattern formation in Drosophila guttifera and analyze gene function to understand the mechanism of pattern formation. By performing transcriptome analysis of small regions from the pupal wings, we were able to identify a group of genes whose expression was high (or low) in the regions where pigmentation occurs and which are under the control of wingless gene. We analyzed the functions of some of these genes in relation to pigmentation by genome editing. We also developed a method to analyze gene functions using the GAL4/UAS system. To clarify the gene regulatory network that controls pigmentation, we analyzed the function of enhancers that regulate the species-specific expression of wingless gene.
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