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Molecular basis for the diversity of gibbons

Research Project

Project/Area Number 18H02516
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 45050:Physical anthropology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Ishida Takafumi  東京大学, 大学院理学系研究科(理学部), 教授 (20184533)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsテナガザル / 社会構造 / ゲノム / 多様性 / 分子基盤 / 系統 / 交雑 / 保全 / 表現型
Outline of Final Research Achievements

Genes coding proteins responsible for the seminal coagulation (SEMG1 and SEMG2) were analyzed in gibbons of three genera to find that 1) the repeat structure of the SEMG1 was consistent in three genera but of the SEMG2 was different in each genus. When dN / dS was determined for the partial sequence of the SEMG2, a strong correlation with the testes weight ratio was found in primates. This result supported higher sperm competition in the multi-male groups in the primates.
GRAS-Di analysis was performed on the genomes of seven species / subspecies of the gibbons, and it was supported that the divergence of gibbons in the continental and in island regions occurred about 3.5 million years ago and then divergence among the Sunda island species took place. Evidence of introgression was detected in several species of the genus Hylobates to indicate that the history of gene flow between these species is relatively old.

Academic Significance and Societal Importance of the Research Achievements

類人猿には珍しい「ペア」を基本とする社会構造を示すテナガザルから得られる知見は、「ヒト」を理解する上で、大型類人猿からは得られない洞察をもたらしてくれる。今回明らかになった、Hylobates属での遺伝子移入は現生Homo sapiensの成立過程を彷彿させるもので、更なる研究が期待される。
テナガザルのDNA・細胞のリソース化は、保全の観点からも、アジアからの情報発信という視点からも、将来に向けた共有できる貴重な研究資産と期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (3 results)

All 2021 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] 日本で飼育されているテナガザルのミトコンドリアDNA(cytochrome b遺伝子) による種判定2021

    • Author(s)
      松平一成、前田洋一、幣原奈央子、石田貴文
    • Journal Title

      日本野生動物医学会誌

      Volume: 26

    • NAID

      130008074401

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular evolution of the semenogelin 1 and 2 and mating system in gibbons2019

    • Author(s)
      Isshiki, M. & Ishida, T.
    • Journal Title

      Am. J. Phys. Anthrop.

      Volume: 168 Issue: 2 Pages: 364-369

    • DOI

      10.1002/ajpa.23748

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] テナガザルの多様な交雑と遺伝子浸透2019

    • Author(s)
      松平一成、石田貴文
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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