• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Adaptive Circulatory Responses to Hypobaric Hypoxia and Cold Environment and Its Polymorphism

Research Project

Project/Area Number 18H02518
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 45060:Applied anthropology-related
Research InstitutionKyushu University

Principal Investigator

Maeda Takafumi  九州大学, 芸術工学研究院, 教授 (90301407)

Co-Investigator(Kenkyū-buntansha) 若林 斉  北海道大学, 工学研究院, 准教授 (50452793)
安河内 彦輝  三重大学, 地域イノベーション推進機構, 助教 (60624525)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords生理人類学 / 環境適応能 / 生理的多型性
Outline of Final Research Achievements

This study investigated the thermal and circulatory responses to hypobaric hypoxia and cold environment that requires conflicting vascular responses such as vasodilation and vasoconstriction. We observed hypobaric hypoxia-induced vasodilation at the forehead and the trunk of the body even during cold exposure, although vasoconstriction occurred in peripheral parts such as fingers. We investigated the influence factors that cause individual differences in the circulatory reactions under the combine environment between hypobaric hypoxia and cold by evaluating the vasomotor response induced by either cold or hypobaric hypoxia, adaptive changes in oxygen saturation and autonomic nervous function to hypobaric hypoxia, and gene expression induced by each environments.

Academic Significance and Societal Importance of the Research Achievements

低圧低酸素と寒冷な環境において、どのような循環調節系の変化が起こっているのかを調べた研究は少ない。本研究の学術的意義は、寒冷環境で生じる体温保持のための皮膚血管収縮反応が、低圧低酸素下で減弱または血管拡張となる部位があることを明らかにした点、低圧低酸素環境に対する適応的変化の個人差を評価した初の研究である点にある。また、本研究の成果は、低圧低酸素と寒冷な環境である高山への登山時に生じる高山病、疲労、低体温症などを予防するための基礎資料となり得る点において社会的な意義を有している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (9 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Effects of acute hypobaric hypoxia on thermoregulatory and circulatory responses during cold air exposure2020

    • Author(s)
      Shin Sora、Yasukochi Yoshiki、Wakabayashi Hitoshi、Maeda Takafumi
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 39 Issue: 1

    • DOI

      10.1186/s40101-020-00237-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcriptomic Changes in Young Japanese Males After Exposure to Acute Hypobaric Hypoxia2020

    • Author(s)
      Yasukochi Yoshiki、Shin Sora、Wakabayashi Hitoshi、Maeda Takafumi
    • Journal Title

      Frontiers in Genetics

      Volume: 11

    • DOI

      10.3389/fgene.2020.559074

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 低圧低酸素環境への短期間反復曝露に対する生理的変化2020

    • Author(s)
      澤崎太一 , 申ソラ、本井碧、前田享史
    • Organizer
      日本生理人類学会第81回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 急性低圧低酸素曝露に対する唾液由来遺伝子発現変動2019

    • Author(s)
      安河内 彦輝, Sora Shin, 若林 斉, 前田 享史
    • Organizer
      日本生理人類学会第80 回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cold-Induced Thermoregulatory Response and Its Influencing Factors2019

    • Author(s)
      Takafumi Maeda
    • Organizer
      The 14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of Severe Cold Environments and Mild Hypobaric Hypoxic Cold Environments on Human Physiology2019

    • Author(s)
      Sora Shin, Yoshiki Yasukochi, Hitoshi Wakabayashi, Takafumi Maeda
    • Organizer
      The 14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human Physiological Responses in A Mild Hypobaric Hypoxia Cold Environment2019

    • Author(s)
      Sora Shin, Yoshiki Yasukochi, Hitoshi Wakabayashi, Takafumi Maeda
    • Organizer
      The 14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Lifestyle and Body Composition on Body Temperature in A Cold Environment2019

    • Author(s)
      Sora Shin, Yoshiki Yasukochi, Hitoshi Wakabayashi, Takafumi Maeda
    • Organizer
      The 14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] 生理人類学2020

    • Author(s)
      安河内朗, 岩永光一, 中山一大, 石橋圭太, 前田享史, 樋口重和, 山内勝也, 福岡義之, 小崎智照, 山崎和彦, 津村有紀, 水野一枝, 山内太郎, 若林斉, 小林宏光, 元村祐貴, 恒次祐子, 下村義弘
    • Total Pages
      260
    • Publisher
      理工図書
    • ISBN
      9784844609025
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi