| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
Rett syndrome and MeCP2 duplication syndrome, which are characterized by various manifestations such as autism and epilepsy, are caused by mutation of MeCP2 gene. MeCP2 is critical for brain development in both neurons and astrocytes. In this study, we examined which MeCP2 in neurons or in astrocytes is critical for brain function of mature mice. We found that overexpression of MeCP2 in astrocytes caused no abnormal phenotypes, while overexpression in neurons induced impaired social behavior. In addition, we succeeded to knockout MeCP2 gene from mature mouse cerebellar neurons.
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