| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
The nature of memory engrams in animal brain remains unclear. Using the leading-edge fluorescent imaging techniques for synaptic plasticity and membrane potential, this project has aimed to clarify the population of activity-dependent synaptic plasticity encoding memory through changing information processing in individual neurons and circuits.
Several lines of live-imaging experiments enabled by our own technical improvements have succeeded in unraveling the spatial information about the functional plasticity in neurons, which will eventually make it possible to fluorescently label the LTD synapses during learning in live animals. In addition, I unexpectedly found a novel long-term plasticity of neuronal information processing at axonal regions after the induction of plasticity at dendrites.
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