| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
GABAergic interneurons regulate activities in local circuits. Parvalbumin-positive neurons are the representative of such neurons, and they are interconnected through dendritic gap junctions that work as electrical synapses. However, this gap junction-coupled network has not yet been incorporated in known neural circuitry mediated by conventional chemical synapses. We explored structural organization of dendritic gap junction network through studies in both hippocampus and somatosensory cortex (barrel field). In both regions, dendrites formed dense network links by gap junctions in such a way that input and output signals can be shared and synchronized through gap junctions in the conventional network mediated by chemical synapses.
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