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Auditory experience dependent neuronal circuit formation, regulating zebra finch song learning.

Research Project

Project/Area Number 18H02531
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionThe University of Tokyo

Principal Investigator

Yazaki-Sugiyama Yoko  東京大学, ニューロインテリジェンス国際研究機構, 特任准教授 (00317512)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords歌学習 / 可塑性 / 発達 / 臨界期 / 学習 / 記憶 / ソングバード / 聴覚 / 神経回路発達 / キンカチョウ
Outline of Final Research Achievements

Our brain is extensively vulnerable in early developmental period, and experiences of interacting with others in our early life impact on the development of social behaviors. Our research unit has been elucidating how our brain circuits are shaped for developing vocal communication skills during development by using a songbird modeling which learn to sing as human babies learn to speak. We have identified the neuronal circuits for detecting social information and forming tutor song memories by social communication. We will further work on to elucidate brain mechanisms for understanding why experiences in early life and real, not artificial, social interaction have impactful. We also will try to understand the biological/neuronal mechanism mediating effect of social interaction with others and long-lasting effect on social behaviors. Our results might be applied to treatments for developmental disorders or help to develop language learnings.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、ヒトの言語発達のメカニズムに対して知見が得られた。どのように脳内で音が処理され、記憶されるのか、また何故発達期の特定の時期にのみ歌学習が起きるのか、基礎的な知識が得られた。これらの基礎研究の知識が、将来的に発達期の神経発達が原因で起きる病気のメカニズムの解明につながる可能性がある。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (14 results)

All 2021 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results)

  • [Journal Article] Genetically-identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.2021

    • Author(s)
      Spool J. A., Macedo-Lima M., Scarpa G., Morohashi Y., Yazaki-Sugiyama Y. and Remage-Healey L.
    • Journal Title

      Curr Biol

      Volume: 31 Issue: 13 Pages: 2831-2843

    • DOI

      10.1016/j.cub.2021.04.039

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early Auditory Experience Modifies Neuronal Firing Properties in the Zebra Finch Auditory Cortex2020

    • Author(s)
      Kudo T, Morhashi Y and *Yazaki-Sugiyama Y
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 14 Pages: 63-63

    • DOI

      10.3389/fncir.2020.570174

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal mechanisms regulating the critical period of sensory experience-dependent song learning.2019

    • Author(s)
      Yazaki-Sugiyama
    • Journal Title

      Special Issue in Neuroscience Research

      Volume: 140 Pages: 53-58

    • DOI

      10.1016/j.neures.2018.11.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Anatomical Connections Between Two Regions of the Higher Auditory Cortex in Zebra Finch Song Memories2021

    • Author(s)
      Sarah Morson, Yuichi Morohashi & Yoko Yazaki-Sugiyama
    • Organizer
      the 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neural mechanisms underlying song recognition in the zebra finch higher auditory cortex2021

    • Author(s)
      Zhehao Cheng & Yoko Yazaki-Sugiyama
    • Organizer
      the 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2020 Annual Research Report
  • [Presentation] Locus coeruleus modulates perception in the auditory cortex during zebra finch song learning,2021

    • Author(s)
      Jelena Katic, Yuichi Morohashi & Yoko Yazaki-Sugiyama
    • Organizer
      Society for Neuroscience, Global Connectome
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intracellular and morphological bases for neural activities used to detect song temporal patterns in the primary auditory forebrain of zebra finches2018

    • Author(s)
      Makoto Araki and Yoko Yazaki-Sugiyama
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Attentional control of song perception in zebra finch song learning2018

    • Author(s)
      Jelena Katic and Yoko Yazaki-Sugiyama
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Selective response of locus coeruleus neurons to extended live tutor singing in zebra finches during song learning2018

    • Author(s)
      Jelena Katic and Yoko Yazaki-Sugiyama
    • Organizer
      The 48th Annual Meeting of Society for neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuronal mechanism for bird song learning under innate restrictions2018

    • Author(s)
      Yoko Yazaki-Sugiyama
    • Organizer
      Symposium at 11th FENS Forum in Neuroscience “Ethology and Evolutions”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] nnate and acquired auditory neuronal pathways for zebra finch song learning2018

    • Author(s)
      Yoko Yazaki-Sugiyama
    • Organizer
      第41回日本神経科学大会 シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Social interactions regulate auditory memory formation in zebra finch song learning2018

    • Author(s)
      Yoko Yazaki-Sugiyama
    • Organizer
      Cold Spring Harbor Asia “Latest Advances in Development & Function of Neuronal Circuits”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Social interactions regulate auditory memory formation in zebra finch song learning2018

    • Author(s)
      Yoko Yazaki-Sugiyama
    • Organizer
      Birdsong 8: “Out on a Limb- unpublished data and new theories
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ‘Innate and acquired auditory neuronal pathways for zebra finch song learning2018

    • Author(s)
      Yoko Yazaki-Sugiyama
    • Organizer
      第41回分子生物学会 シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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