| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
It was found that granule cell progenitors (GCPs) in the cerebellum progressively lose their "undifferentiated" and "proliferative" nature and eventually differentiate into granule cells. Furthermore, in this stepwise transition, cyclin D1, which was known to activate cell proliferation, was found to stabilize the ATOH1 protein via phosphorylation, thereby maintaining the undifferentiated nature of GCPs. It was also revealed that the WNT protein, which increases with brain development, and the PROX1 molecule whose expression is induced by the WNT protein, gradually decrease the amount of cyclin D1, thereby accelerating GC development.
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