| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
In this study, I tried to elucidate neural activity dependency and its molecular basis of synapse elimination (selective strengthening and elimination of synapses). I have elucidated the mechanism of postnatal development of the climbing fiber to Purkinje cell synapse in the cerebellum as a model system for synapse elimination. I have identified neural activity dependency in synapse elimination and retrograde signaling molecules that work downstream of neural activity and transmit from the postsynaptic to the presynaptic region. In the present study, I identified unknown retrograde signaling molecules using the developed screening system and clarified how neural activity regulates these molecules. Furthermore, I clarified how neural activity-dependent and activity-independent mechanisms cooperate to selectively strengthen or eliminate synapses.
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