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Understanding of motor control and learning and memory mechanism using mice harboring altered expression of D1/D2 dopamine receptors

Research Project

Project/Area Number 18H02540
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionNiigata University

Principal Investigator

Sasaoka Toshikuni  新潟大学, 脳研究所, 教授 (50222005)

Co-Investigator(Kenkyū-buntansha) 南部 篤  生理学研究所, システム脳科学研究領域, 教授 (80180553)
知見 聡美  生理学研究所, システム脳科学研究領域, 助教 (30396262)
木津川 尚史  立命館大学, 生命科学部, 教授 (10311193)
崎村 建司  新潟大学, 脳研究所, フェロー (40162325)
田井中 一貴  新潟大学, 脳研究所, 教授 (80506113)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsドーパミン受容体 / 大脳基底核回路 / 運動制御 / 学習記憶 / パーキンソン病 / 報酬学習/忌避学習 / 全脳透明化 / 画像解析 / 報酬学習/忌避学習 / 大脳基底核
Outline of Final Research Achievements

To elucidate the cause of motor symptoms in Parkinson's disease, we analyzed the mechanism of motor control using genetically engineered mice, focusing on the roles of D1 and D2 dopamine receptors (D1R and D2R) and NMDA receptor-mediated signal transduction, and especially found the importance of D1R-mediated signal transduction. In addition, we found that D1R-mediated signaling is important for learning and memory of risk avoidance induced by aversive stimuli, and identified brain regions activated by aversive stimuli and molecules responsible for signaling.

Academic Significance and Societal Importance of the Research Achievements

本研究は、高齢者の主要な神経疾患であるパーキンソン病の運動症状と非運動症状の原因を明らかにする目的で、それらの症状に深く関わるドーパミン受容体及びNMDA受容体を介する情報伝達の変容について、運動の制御及び認知と学習記憶の分子機構におけるD1及びD2ドーパミン受容体及びNMDA受容体の働きの理解を深めたことで学術的意義を持ち、さらに本研究成果は、本疾患の克服に向けた予防や治療の戦略に方向性を示し、社会的要請に応える研究への発展が考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (156 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (10 results) Journal Article (83 results) (of which Int'l Joint Research: 37 results,  Peer Reviewed: 79 results,  Open Access: 62 results) Presentation (49 results) (of which Int'l Joint Research: 7 results,  Invited: 12 results) Book (3 results) Remarks (8 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] テキサス大学(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ルンド大学(スウェーデン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] CINAC-HM Hospital Puerta del Sur(スペイン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] イリノイ大学シャンペーン校(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] オーフス大 DANDRITE研究所(デンマーク)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] CINAC-HM Hospital Puerta del Sur(スペイン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ルンド大学(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] イリノイ大学シャンペーン校(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] DANDRITE, Aarhus University(デンマーク)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] San Pablo-CEU University(スペイン)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Ezh1 regulates expression of <i>Cpg15/Neuritin</i> in mouse cortical neurons2021

    • Author(s)
      Shun Utsunomiya#, Yusuke Kishi#, Masafumi Tsuboi, Daichii Kawaguchi, Yukiko Gotoh, Manabu Abe, Kenji Sakimura, Kazuma Maeda, and Hiroshi Takemoto (#Equal contribution)
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 15 Issue: 2 Pages: 55-65

    • DOI

      10.5582/ddt.2021.01017

    • NAID

      130008037031

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2021-04-30
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons2021

    • Author(s)
      Kawahata Ichiro、Sekimori Tomoki、Wang Haoyang、Wang Yanyan、Sasaoka Toshikuni、Bousset Luc、Melki Ronald、Mizobata Tomohiro、Kawata Yasushi、Fukunaga Kohji
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 1 Pages: 49-49

    • DOI

      10.3390/biomedicines9010049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent dofferences in dopamine biosynthetic pathways.2021

    • Author(s)
      Katsuya Miyajima, Chiaki Kawamoto, Satoshi Hara, Masayo Mori-Kojima, Tamae Ohye, Chiho Sumi-Ichinose, Nae Saito, Toshikuni Sasaoka, Daniel Metzger, Hiroshi Ichinose
    • Journal Title

      Journal of Biological Chemistry

      Volume: - Pages: 100544-100544

    • DOI

      10.1016/j.jbc.2021.100544

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormal cortico-basal ganglia neurotransmission in a mouse model of L-DOPA-induced dyskinesia.2021

    • Author(s)
      Dwi Wahyu I, Chiken S, Hasegawa T, Sano H, Nambu A
    • Journal Title

      J Neurosci

      Volume: 41 Issue: 12 Pages: 2668-2683

    • DOI

      10.1523/jneurosci.0267-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention2021

    • Author(s)
      Fukata Yuko、Chen Xiumin、Chiken Satomi、Hirano Yoko、Yamagata Atsushi、Inahashi Hiroki、Sanbo Makoto、Sano Hiromi、Goto Teppei、Hirabayashi Masumi、Kornau Hans-Christian、Pruss Harald、Nambu Atsushi、Fukai Shuya、Nicoll Roger A.、Fukata Masaki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 3 Pages: 1-12

    • DOI

      10.1073/pnas.2022580118

    • NAID

      120006976050

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing.2021

    • Author(s)
      Kubota SI, Takahashi K, Mano T, Matsumoto K, Katsumata T, Shi S, Tainaka K, Ueda HR, Ehata S, Miyazono K.
    • Journal Title

      Commun. Biol.

      Volume: 4 Issue: 1 Pages: 294-294

    • DOI

      10.1038/s42003-021-01786-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional understanding of the morphological complexity of the human uterine endometrium2021

    • Author(s)
      Yamaguchi Manako、Yoshihara Kosuke、Suda Kazuaki、Nakaoka Hirofumi、Yachida Nozomi、Ueda Haruka、Sugino Kentaro、Mori Yutaro、Yamawaki Kaoru、Tamura Ryo、Ishiguro Tatsuya、Motoyama Teiichi、Watanabe Yu、Okuda Shujiro、Tainaka Kazuki、Enomoto Takayuki
    • Journal Title

      iScience

      Volume: 24 Issue: 4 Pages: 102258-102258

    • DOI

      10.1016/j.isci.2021.102258

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kv11 (ether-a-go-go-related gene) voltage-dependent K + channels promote resonance and oscillation of subthreshold membrane potentials2021

    • Author(s)
      Matsuoka Toshinori, Yamasaki Miwako, Abe Manabu, Matsuda Yukiko, Morino Hiroyuki, Kawakami Hideshi, Sakimura Kenji, Watanabe Masahiko, Hashimoto Kouichi
    • Journal Title

      The Journal of Physiology

      Volume: 599(2) Issue: 2 Pages: 547-569

    • DOI

      10.1113/jp280342

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cav3.1 t‐type calcium channel is critical for cell proliferation and survival in newly generated cells of the adult hippocampus2021

    • Author(s)
      Yabuki Yasushi、Matsuo Kazuya、Yu Mengze、Xu Jing、Sakimura Kenji、Shioda Norifumi、Fukunaga Kohji
    • Journal Title

      Acta Physiologica

      Volume: e13613 Issue: 1

    • DOI

      10.1111/apha.13613

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

    • Author(s)
      Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 16-16

    • DOI

      10.1038/s41467-020-20185-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterogeneity of microglial proton channel in different brain regions and its relationship with aging.2021

    • Author(s)
      Kawai T,Takao K,Akter S,Abe M,Sakimura K,Miyakawa T,Okamura Y
    • Journal Title

      J Neurochem.

      Volume: - Issue: 3 Pages: 624-641

    • DOI

      10.1111/jnc.15292

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.2021

    • Author(s)
      Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
    • Journal Title

      Mol Brain

      Volume: 14 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s13041-020-00713-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer2021

    • Author(s)
      Yuza Kizuki、Nagahashi Masayuki、Ichikawa Hiroshi、Hanyu Takaaki、Nakajima Masato、Shimada Yoshifumi、Ishikawa Takashi、Sakata Jun、Takeuchi Shiho、Okuda Shujiro、Matsuda Yasunobu、Abe Manabu、Sakimura Kenji、Takabe Kazuaki、Wakai Toshifumi
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: N/A Issue: 9 Pages: 2231-2241

    • DOI

      10.1007/s11605-020-04889-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure2021

    • Author(s)
      Bertrand Jacques A、Woodward David F、Sherwood Joseph M、Spenlehauer Alice、Silvestri Cristoforo、Piscitelli Fabiana、Marzo Vincenzo Di、Yamazaki Maya、Sakimura Kenji、Inoue Yoko、Watanabe Kikuko、Overby Darryl R
    • Journal Title

      Prostaglandins, Leukotrienes and Essential Fatty Acids

      Volume: 165 Pages: 102235-102235

    • DOI

      10.1016/j.plefa.2020.102235

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of Mutant Sik3Sleepy Allele in Neurons in Late Infancy Increases Sleep Need2021

    • Author(s)
      Iwasaki Kanako, Fujiyama Tomoyuki, Nakata Shinya, Park Minjeong, Miyoshi Chika, Hotta-Hirashima Noriko, Ikkyu Aya, Kakizaki Miyo, Sugiyama Fumihiro, Mizuno Seiya, Abe Manabu, Sakimura Kenji, Takahashi Satoru, Funato Hiromasa, Yanagisawa Masashi
    • Journal Title

      The Journal of Neuroscience

      Volume: 41 Issue: 12 Pages: 2733-2746

    • DOI

      10.1523/jneurosci.1004-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine‐1‐phosphate and ceramide in human hepatocellular carcinoma2021

    • Author(s)
      Miura Kohei、Nagahashi Masayuki、Prasoon Pankaj、Hirose Yuki、Kobayashi Takashi、Sakata Jun、Abe Manabu、Sakimura Kenji、Matsuda Yasunobu、Butash Ali L.、Katsuta Eriko、Takabe Kazuaki、Wakai Toshifumi
    • Journal Title

      Hepatology Research

      Volume: 51 Issue: 5 Pages: 614-626

    • DOI

      10.1111/hepr.13625

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background2021

    • Author(s)
      Iida Izumi、Konno Kohtarou、Natsume Rie、Abe Manabu、Watanabe Masahiko、Sakimura Kenji、Terunuma Miho
    • Journal Title

      Behavioural Brain Research

      Volume: 405 Pages: 113194-113194

    • DOI

      10.1016/j.bbr.2021.113194

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activity‐induced secretion of semaphorin 3A mediates learning2021

    • Author(s)
      Jitsuki‐Takahashi Aoi、Jitsuki Susumu、Yamashita Naoya、Kawamura Meiko、Abe Manabu、Sakimura Kenji、Sano Akane、Nakamura Fumio、Goshima Yoshio、Takahashi Takuya
    • Journal Title

      European Journal of Neuroscience

      Volume: 00 Issue: 10 Pages: 1-15

    • DOI

      10.1111/ejn.15210

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 増大特集 脳の発振現象-基礎から臨床へ ドーパミンおよびNMDA受容体と大脳基底核回路の機能解析2020

    • Author(s)
      齊藤 奈英、笹岡 俊邦
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Issue: 11 Pages: 1135-1142

    • DOI

      10.11477/mf.1416201666

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2020-11-01
    • Related Report
      2020 Annual Research Report
  • [Journal Article] 増大特集 脳の発振現象-基礎から臨床へ ネットワーク病としてのパーキンソン病2020

    • Author(s)
      南部 篤、知見 聡美
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Issue: 11 Pages: 1159-1171

    • DOI

      10.11477/mf.1416201669

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2020-11-01
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex2020

    • Author(s)
      Saito Nae、Tainaka Kazuki、Macpherson Tom、Hikida Takatoshi、Yamaguchi Shun、Sasaoka Toshikuni
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 58-65

    • DOI

      10.1016/j.neures.2020.04.006

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice2020

    • Author(s)
      Kitahara Akihiko、Ran Qingsong、Oda Kanako、Yasue Akihiro、Abe Manabu、Ye Xulu、Sasaoka Toshikuni、Tsuchida Masanori、Sakimura Kenji、Ajioka Yoichi、Saijo Yasuo、Zhou Qiliang
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 6 Pages: 107626-107626

    • DOI

      10.1016/j.celrep.2020.107626

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure2020

    • Author(s)
      Yamaguchi Toshihiro、Sumida Tomokazu S.、Nomura Seitaro、Satoh Masahiro、Higo Tomoaki、Ito Masamichi、Ko Toshiyuki、Fujita Kanna、Sweet Mary E.、Sanbe Atsushi、Yoshimi Kenji、Manabe Ichiro、Sasaoka Toshikuni、Taylor Matthew R. G.、Toko Haruhiro、Takimoto Eiki、Naito Atsuhiko T.、Komuro Issei
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 4364-4364

    • DOI

      10.1038/s41467-020-18128-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo2020

    • Author(s)
      Ran Qingsong、Zhou Qiliang、Oda Kanako、Yasue Akihiro、Abe Manabu、Ye Xulu、Li Yingchun、Sasaoka Toshikuni、Sakimura Kenji、Ajioka Yoichi、Saijo Yasuo
    • Journal Title

      Frontiers in Endocrinology

      Volume: 11

    • DOI

      10.3389/fendo.2020.609697

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Specific Neuroligin3?αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus2020

    • Author(s)
      Uchigashima Motokazu、Konno Kohtarou、Demchak Emily、Cheung Amy、Watanabe Takuya、Keener David G、Abe Manabu、Le Timmy、Sakimura Kenji、Sasaoka Toshikuni、Uemura Takeshi、Imamura Kawasawa Yuka、Watanabe Masahiko、Futai Kensuke
    • Journal Title

      eLife

      Volume: 9

    • DOI

      10.7554/elife.59545

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Weakly correlated activity of pallidal neurons in behaving monkeys2020

    • Author(s)
      Wongmassang W, Hasegawa T, Chiken S, Nambu A
    • Journal Title

      Eur J Neurosci

      Volume: 53 Issue: 7 Pages: 2178-2191

    • DOI

      10.1111/ejn.14903

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical control of subthalamic neuronal activity through the hyperdirect and indirect pathways in monkeys2020

    • Author(s)
      Polyakova Z, Chiken S, Hatanaka N, Nambu A
    • Journal Title

      J Neurosci

      Volume: 40 Issue: 39 Pages: 7451-7463

    • DOI

      10.1523/jneurosci.0772-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex2020

    • Author(s)
      Watanabe H, Sano H, Chiken S, Kobayashi K, Fukata Y, Fukata M, Mushiake H, Nambu A
    • Journal Title

      Nat Commun

      Volume: 11 Issue: 1 Pages: 3253-3253

    • DOI

      10.1038/s41467-020-16883-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia2020

    • Author(s)
      Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain MI, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H
    • Journal Title

      Glia

      Volume: - Issue: 11 Pages: 2330-2344

    • DOI

      10.1002/glia.23843

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebellar outputs contribute to spontaneous and movement-related activity in the motor cortex of monkeys2020

    • Author(s)
      Sano Nobuya、Nakayama Yoshihisa、Ishida Hiroaki、Chiken Satomi、Hoshi Eiji、Nambu Atsushi、Nishimura Yukio
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 10-21

    • DOI

      10.1016/j.neures.2020.03.010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parkinsonism differently affects the single neuronal activity in the primary and supplementary motor areas in monkeys:An investigation in linear and non-linear domains.2020

    • Author(s)
      Darbin O, Hatanaka N, Takara S, Kaneko N, Chiken S, Naritoku D, Martino A, Nambu A
    • Journal Title

      International Journal of Neural Systems,

      Volume: 30 Issue: 02 Pages: 2050010-2050010

    • DOI

      10.1142/s0129065720500100

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo2020

    • Author(s)
      Kunisawa Kazuo、Hatanaka Nobuhiko、Shimizu Takeshi、Kobayashi Kenta、Osanai Yasuyuki、Mouri Akihiro、Shi Qian、Bhat Manzoor A.、Nambu Atsushi、Ikenaka Kazuhiro
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 159-159

    • DOI

      10.1186/s13041-020-00698-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues2020

    • Author(s)
      Susaki Etsuo A.、Shimizu Chika、Kuno Akihiro、Tainaka Kazuki、Li Xiang、Shibayama Mitsuhiro、Ueda Hiroki R. et al.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1982-1982

    • DOI

      10.1038/s41467-020-15906-5

    • NAID

      120006956725

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum2020

    • Author(s)
      Rai Yurie、Watanabe Takaki、Matsuyama Kyoko、Sakimura Kenji、Uesaka Naofumi、Kano Masanobu
    • Journal Title

      Neuroscience

      Volume: 462 Pages: 36

    • DOI

      10.1016/j.neuroscience.2020.04.035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AUTS2 regulation of synapses for proper synaptic inputs and social communication.2020

    • Author(s)
      Hori Kei、Yamashiro Kunihiko、Nagai Taku、... Yamada Mitsuhiko、Yamada Kiyofumi、Hoshino Mikio
    • Journal Title

      iScience

      Volume: ー Issue: 6 Pages: 101183-101183

    • DOI

      10.1016/j.isci.2020.101183

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A discrete neuronal circuit induces a hibernation-like state in rodents2020

    • Author(s)
      Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.
    • Journal Title

      Nature

      Volume: - Issue: 7814 Pages: 109-114

    • DOI

      10.1038/s41586-020-2163-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cholinergic modulation of CRH and non-CRH neurons in Barrington’s nucleus of the mouse2020

    • Author(s)
      Kawatani Masahiro、Itoi Keiichi、Talukder Ashraf Hossain、Uchida Katsuya、Sakimura Kenji、Kawatani Masahito
    • Journal Title

      Journal of Neurophysiology

      Volume: 124 Issue: 2 Pages: 443-457

    • DOI

      10.1152/jn.00342.2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Significance of autoantibodies in autoimmune encephalitis in relation to antigen localization: a non-systematic review2020

    • Author(s)
      Keiko Tanaka, Meiko Kawamura, Kenji Sakimura, Nobuo Kato.
    • Journal Title

      Int J Mol Sci21

      Volume: 21 Issue: 14 Pages: 1-15

    • DOI

      10.3390/ijms21144941

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons2020

    • Author(s)
      Nagano Seiichi、Jinno Junki、Abdelhamid Rehab F.、Jin Yinshi、Shibata Megumi、Watanabe Shohei、Hirokawa Sachiko、Nishizawa Masatoyo、Sakimura Kenji、Onodera Osamu、Okada Hironori、Okada Takashi、Saito Yuko、Takahashi-Fujigasaki Junko、Murayama Shigeo、Wakatsuki Shuji、Mochizuki Hideki、Araki Toshiyuki
    • Journal Title

      Acta Neuropathologica

      Volume: 140 Issue: 5 Pages: 695-713

    • DOI

      10.1007/s00401-020-02205-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway2020

    • Author(s)
      Hirose Yuki、Kitazono Tomohiro、Sezaki Maiko、Abe Manabu、Sakimura Kenji、Funato Hiromasa、Handa Hiroshi、Vogt Kaspar E.、Yanagisawa Masashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 37 Pages: 23106-23112

    • DOI

      10.1073/pnas.1917701117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix2020

    • Author(s)
      Ito Hikaru、Nozaki Kanako、Sakimura Kenji、Abe Manabu、Yamawaki Shigeto、Aizawa Hidenori
    • Journal Title

      Neuropsychopharmacology

      Volume: 46 Issue: 2 Pages: 442-454

    • DOI

      10.1038/s41386-020-00843-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of hepatic oxidative stress by voltage‐gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism2020

    • Author(s)
      Kawai Takafumi、Kayama Kento、Tatsumi Shoki、Akter Sharmin、Miyawaki Nana、Okochi Yoshifumi、Abe Manabu、Sakimura Kenji、Yamamoto Hiroyasu、Kihara Shinji、Okamura Yasushi
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 12 Pages: 15805-15821

    • DOI

      10.1096/fj.202001056rrr

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased Proliferation in the Neurogenic Niche, Disorganized Neuroblast Migration, and Increased Oligodendrogenesis in Adult Netrin-5-Deficient Mice2020

    • Author(s)
      Ikegaya Shunsuke、Iga Yurika、Mikawa Sumiko、Zhou Li、Abe Manabu、Sakimura Kenji、Sato Kohji、Yamagishi Satoru
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14 Pages: 570974-570974

    • DOI

      10.3389/fnins.2020.570974

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves2020

    • Author(s)
      Ikeda Hiroko、Yonemochi Naomi、Mikami Risa、Abe Manabu、Kawamura Meiko、Natsume Rie、Sakimura Kenji、Waddington John L.、Kamei Junzo
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 22347-22347

    • DOI

      10.1038/s41598-020-79292-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice2020

    • Author(s)
      Shuntaro Uchida, Shingo Soya, Yuki C Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
    • Journal Title

      journal of neuroscience

      Volume: 41 Issue: 7 Pages: 1582-1596

    • DOI

      10.1523/jneurosci.0688-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] パーキンソン病の病態生理2020

    • Author(s)
      知見聡美、南部篤
    • Journal Title

      Clinical Neuroscience

      Volume: 38 Pages: 823-826

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Cardiac Dopamine D1 Receptor Triggers Ventricular Arrhythmia in Chronic Heart Failure2020

    • Author(s)
      Toshihiro Yamaguchi、Tomokazu Sumida、Seitaro Nomura、Masahiro Satoh、Tomoaki Higo、Masamichi Ito、Toshiyuki Ko、Kanna Fujita、Mary E. Sweet、Atsushi Sanbe、Kenji Yoshimi、Ichiro Manabe、 Toshikuni Sasaoka、Matthew R. G. Taylor、Haruhiro Toko、Eiki Takimoto、Atsuhiko T. Naito、Issei Komuro
    • Journal Title

      Nature Communications -

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dense projection of Stilling’s nucleus spinocerebellar axons that convey tail proprioception to the midline area in lobule VIII of the mouse cerebellum.2020

    • Author(s)
      Luo Y, Onozato T, Wu X, Sasamura K, Sakimura K, Sugihara I
    • Journal Title

      Brain Structure and Function

      Volume: 225 Issue: 2 Pages: 621-638

    • DOI

      10.1007/s00429-020-02025-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors2020

    • Author(s)
      Luo, L.、19名略、Sinclair, J. L.、Stogsdill, J. A.、Traunmuller, L.、Wang, J.、Wortel, J.、 You, W.、 Abumaria, N.、 Beier, K. T.、 Brose, N.、 Burgess, H. A.、 Cepko, C. L.、 Cloutier, J. F.、 Eroglu, C.、 Goebbels, S.、 Kaeser, P. S.、 Kay, J. N.、 Lu, W.、 Luo, L.、 Mandai, K.、15名略、Kawabe, H.、 Craig, A. M.
    • Journal Title

      Neuron

      Volume: 106 Issue: 1 Pages: 37-65

    • DOI

      10.1016/j.neuron.2020.01.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior2020

    • Author(s)
      Nakamoto Chihiro、Kawamura Meiko、Nakatsukasa Ena、Natsume Rie、Takao Keizo、Watanabe Masahiko、Abe Manabu、Takeuchi Tomonori、Sakimura Kenji
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 2 Pages: 0229288-0229288

    • DOI

      10.1371/journal.pone.0229288

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn2020

    • Author(s)
      Kiguchi Norikazu、Uta Daisuke、Ding Huiping、Uchida Hitoshi、Saika Fumihiro、Matsuzaki Shinsuke、Fukazawa Yohji、Abe Manabu、Sakimura Kenji、Ko Mei-Chuan、Kishioka Shiroh
    • Journal Title

      Neuropharmacology

      Volume: 170 Pages: 108025-108025

    • DOI

      10.1016/j.neuropharm.2020.108025

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dopamine D1 and muscarinic acetylcholine receptors in dorsal striatum are required for high speed running2019

    • Author(s)
      Nakamura Toru、Rios Luis Carl、Yagi Takeshi、Sasaoka Toshikuni、Kitsukawa Takashi
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 1-8

    • DOI

      10.1016/j.neures.2019.12.001

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crucial Role of Dopamine D2 Receptor Signaling in Nicotine-Induced Conditioned Place Preference2019

    • Author(s)
      Wilar Gofarana、Shinoda Yasuharu、Sasaoka Toshikuni、Fukunaga Kohji
    • Journal Title

      Molecular Neurobiology

      Volume: 56 Issue: 12 Pages: 7911-7928

    • DOI

      10.1007/s12035-019-1635-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 422019

    • Author(s)
      Hashiguchi S, Doi H, Kunii M, Nakamura Y, Shimuta M, (32名略) Ishikawa T, Tanaka F
    • Journal Title

      Neurobiology of Disease

      Volume: 130 Pages: 104516-104516

    • DOI

      10.1016/j.nbd.2019.104516

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons2019

    • Author(s)
      Shioda Norifumi、Imai Yoshiki、Yabuki Yasushi、Sugimoto Wataru、Yamaguchi Kouya、Wang Yanyan、Hikida Takatoshi、Sasaoka Toshikuni、Mieda Michihiro、Fukunaga Kohji
    • Journal Title

      The Journal of Neuroscience

      Volume: 39 Issue: 38 Pages: 7551-7563

    • DOI

      10.1523/jneurosci.0079-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rapid chemical clearing of white matter in the post-mortem human brain by 1,2-hexanediol delipidation.2019

    • Author(s)
      Inoue M, Saito R, Kakita A, Tainaka K.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 29 Issue: 15 Pages: 1886-1890

    • DOI

      10.1016/j.bmcl.2019.05.049

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell memory trace imaging with immediate-early genes2019

    • Author(s)
      Sauvage Magdalena、Kitsukawa Takashi、Atucha Erika
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 326 Pages: 108368-108368

    • DOI

      10.1016/j.jneumeth.2019.108368

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice2019

    • Author(s)
      Sano Hiromi、Nambu Atsushi
    • Journal Title

      Neurochemistry International

      Volume: 124 Pages: 171-180

    • DOI

      10.1016/j.neuint.2019.01.011

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral splint ameliorates tic symptoms in patients with tourette syndrome2019

    • Author(s)
      Murakami Jumpei、Tachibana Yoshihisa、Akiyama Shigehisa、Kato Takafumi、Taniguchi Aya、Nakajima Yoshiaki、Shimoda Mao、Wake Hiroaki、Kano Yukiko、Takada Masahiko、Nambu Atsushi、Yoshida Atsushi
    • Journal Title

      Movement Disorders

      Volume: 34 Issue: 10 Pages: 1577-1578

    • DOI

      10.1002/mds.27819

    • NAID

      120006799316

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arm movements induced by noninvasive optogenetic stimulation of the motor cortex in the common marmoset2019

    • Author(s)
      Ebina Teppei、Obara Keitaro、Watakabe Akiya、Masamizu Yoshito、Terada Shin-Ichiro、Matoba Ryota、Takaji Masafumi、Hatanaka Nobuhiko、Nambu Atsushi、Mizukami Hiroaki、Yamamori Tetsuo、Matsuzaki Masanori
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 45 Pages: 22844-22850

    • DOI

      10.1073/pnas.1903445116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired cortico-striatal excitatory transmission triggers epilepsy2019

    • Author(s)
      Miyamoto Hiroyuki、Tatsukawa Tetsuya、Shimohata Atsushi、Yamagata Tetsushi、Suzuki Toshimitsu、Amano Kenji、Mazaki Emi、Raveau Matthieu、Ogiwara Ikuo、Oba-Asaka Atsuko、Hensch Takao K.、Itohara Shigeyoshi、Sakimura Kenji、Kobayashi Kenta、Kobayashi Kazuto、Yamakawa Kazuhiro
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1917-1917

    • DOI

      10.1038/s41467-019-09954-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics2019

    • Author(s)
      Inoue M, Takeuchi A, Manita S, Horigane S-i, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.
    • Journal Title

      Cell

      Volume: 177 Issue: 5 Pages: 1346

    • DOI

      10.1016/j.cell.2019.04.007

    • URL

      https://localhost/en/publications/a48843c1-543d-4414-a93c-3cab0e1df627

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice2019

    • Author(s)
      Sou Yu-shin、Kakuta Soichiro、Kamikubo Yuji、Niisato Kazue、Sakurai Takashi、Parajuli Laxmi Kumar、Tanida Isei、Saito Hiromitsu、Suzuki Noboru、Sakimura Kenji、Maeda Yusuke、Kinoshita Taroh、Uchiyama Yasuo、Koike Masato
    • Journal Title

      eNeuro

      Volume: 6 Issue: 3 Pages: 0427-18

    • DOI

      10.1523/eneuro.0427-18.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice2019

    • Author(s)
      Chowdhury Srikanta、Hung Chi Jung、Izawa Shuntaro、Inutsuka Ayumu、Kawamura Meiko、Kawashima Takashi、Bito Haruhiko、Imayoshi Itaru、Abe Manabu、Sakimura Kenji、Yamanaka Akihiro
    • Journal Title

      eLife

      Volume: 8 Pages: 1-25

    • DOI

      10.7554/elife.44927

    • NAID

      120006888021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice2019

    • Author(s)
      Chowdhury Srikanta、Matsubara Takanori、Miyazaki Toh、Ono Daisuke、Fukatsu Noriaki、Abe Manabu、Sakimura Kenji、Sudo Yuki、Yamanaka Akihiro
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.44928

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity2019

    • Author(s)
      Doi Masao、Shimatani Hiroyuki、Atobe Yuta、Murai Iori、Hayashi Hida、Takahashi Yukari、Fustin Jean-Michel、Yamaguchi Yoshiaki、Kiyonari Hiroshi、Koike Nobuya、Yagita Kazuhiro、Lee Choogon、Abe Manabu、Sakimura Kenji、Okamura Hitoshi
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2563-2563

    • DOI

      10.1038/s41467-019-10532-2

    • NAID

      120006644061

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-22019

    • Author(s)
      Martinez-Torres Sara、Cutando Laura、Pastor Antoni、Kato Ako、Sakimura Kenji、de la Torre Rafael、Valjent Emmanuel、Maldonado Rafael、Kano Masanobu、Ozaita Andres
    • Journal Title

      Brain, Behavior, and Immunity

      Volume: 81 Pages: 399

    • DOI

      10.1016/j.bbi.2019.06.036

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1?Akt signaling pathway2019

    • Author(s)
      Nishino Kohei、Watanabe Seiji、Shijie Jin、Murata Yuri、Oiwa Kotaro、Komine Okiru、Endo Fumito、Tsuiji Hitomi、Abe Manabu、Sakimura Kenji、Mishra Amit、Yamanaka Koji
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Issue: 1 Pages: 118-118

    • DOI

      10.1186/s40478-019-0776-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differential Roles of Each Orexin Receptor Signaling in Obesity2019

    • Author(s)
      Kakizaki Miyo、Tsuneoka Yousuke、Takase Kenkichi、Kim Staci J.、Choi Jinhwan、Ikkyu Aya、Abe Manabu、Sakimura Kenji、Yanagisawa Masashi、Funato Hiromasa
    • Journal Title

      iScience

      Volume: 20 Pages: 1-13

    • DOI

      10.1016/j.isci.2019.09.003

    • NAID

      120007132695

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modular organization of cerebellar climbing fiber inputs during goal-directed behavior2019

    • Author(s)
      Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K.
    • Journal Title

      Elife.

      Volume: 8

    • DOI

      10.7554/elife.47021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain2019

    • Author(s)
      Nakamoto Chihiro、Konno Kohtarou、Miyazaki Taisuke、Nakatsukasa Ena、Natsume Rie、Abe Manabu、Kawamura Meiko、Fukazawa Yugo、Shigemoto Ryuichi、Yamasaki Miwako、Sakimura Kenji、Watanabe Masahiko
    • Journal Title

      Journal of Comparative Neurology

      Volume: 528 Issue: 6 Pages: 1003-1027

    • DOI

      10.1002/cne.24792

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endocannabinoid Signaling from 2-Arachidonoylglycerol to CB<sub>1</sub> Cannabinoid Receptor Facilitates Reward-based Learning of Motor Sequence2019

    • Author(s)
      Tanigami H, Yoneda M, Tabata Y, Echigo R, Kikuchi Y, Yamazaki M, Kishimoto Y, Sakimura K, Kano M, Ohno-Shosaku T
    • Journal Title

      Neuroscience

      Volume: 421 Pages: 1

    • DOI

      10.1016/j.neuroscience.2019.09.040

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarized PtdIns(4,5)P2distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility2019

    • Author(s)
      Kawai Takafumi、Miyata Haruhiko、Nakanishi Hiroki、Sakata Souhei、Morioka Shin、Sasaki Junko、Watanabe Masahiko、Sakimura Kenji、Fujimoto Toyoshi、Sasaki Takehiko、Ikawa Masahito、Okamura Yasushi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 51 Pages: 26020-26028

    • DOI

      10.1073/pnas.1916867116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4.2019

    • Author(s)
      Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.
    • Journal Title

      Lab Invest.

      Volume: 99(2) Issue: 2 Pages: 210-230

    • DOI

      10.1038/s41374-018-0118-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differential behavioral phenotypes of Dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages2018

    • Author(s)
      Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T.
    • Journal Title

      International Journal of Developmental Neuroscience

      Volume: 66 Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.ijdevneu.2017.11.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.2018

    • Author(s)
      Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
    • Journal Title

      Cell Rep.

      Volume: 24 Issue: 8 Pages: 2196-2210

    • DOI

      10.1016/j.celrep.2018.07.056

    • NAID

      120006542018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue2018

    • Author(s)
      Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
    • Journal Title

      Proceedings of International Symposium on Animal Production and Conservation for Sustainable Development 2018

      Volume: なし Pages: 31-33

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Development of stereotaxic recording system for awake marmosets (Callithrix jacchus).2018

    • Author(s)
      Wakabayashi M, Koketsu D, Kondo H, Sato S, Ohara K, Polyakova Z, Chiken S, Hatanaka N, Nambu A
    • Journal Title

      Neurosci Res

      Volume: in press Pages: 37-45

    • DOI

      10.1016/j.neures.2018.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks2018

    • Author(s)
      Ebina T, Masamizu Y, Tanaka YR, Watakabe A, Hirakawa R, Hirayama Y, Hira R, Terada S, Koketsu D, Hikosaka K, Mizukami H, Nambu A, Sasaki E, Yamamori Y, Matsuzaki M
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1 Pages: 1879-1879

    • DOI

      10.1038/s41467-018-04286-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recruitment of calbindin into nigral dopamine neurons protects against drug-induced parkinsonism. Mov Disord [Epub ahead of print] doi: 10.1002/mds.1072018

    • Author(s)
      Inoue K, Miyachi S, Nishi K, Okado H, Nagai Y, Minamimoto T, Nambu A, Takada M
    • Journal Title

      Mov Disord

      Volume: - Issue: 2 Pages: 200-209

    • DOI

      10.1002/mds.107

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018

    • Author(s)
      Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
    • Journal Title

      Neuron

      Volume: 99(6) Issue: 6 Pages: 1302-1314

    • DOI

      10.1016/j.neuron.2018.08.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Length of myelin internodes of individual oligodendrocytes is controlled by microenvironment influenced by normal and input-deprived axonal activities in sensory deprived mouse models2018

    • Author(s)
      Osanai Yasuyuki、Shimizu Takeshi、Mori Takuma、Hatanaka Nobuhiko、Kimori Yoshitaka、Kobayashi Kenta、Koyama Shinsuke、Yoshimura Yumiko、Nambu Atsushi、Ikenaka Kazuhiro
    • Journal Title

      Glia

      Volume: 66 Issue: 11 Pages: 2514-2525

    • DOI

      10.1002/glia.23502

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration.2018

    • Author(s)
      Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K.
    • Journal Title

      Science Advances

      Volume: 4 Issue: 12 Pages: 0618-0618

    • DOI

      10.1126/sciadv.aav0618

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Analysis of the role of basal ganglia circuit using dopamine receptor and NMDA receptor mutant mice2020

    • Author(s)
      Toshikuni Sasaoka et al.
    • Organizer
      The 10th BRI International Symposium, ADVANCED BRAIN IMAGING FOR THE FUTURE
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] Elucidation of motor control and aversive memory formation mechanism by dopamine using dopamine D1 receptor gene modified mice2020

    • Author(s)
      Nae Saito, Toshikuni Sasaoka et al.
    • Organizer
      The 10th BRI International Symposium, ADVANCED BRAIN IMAGING FOR THE FUTURE,
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of alteration in motor control and learning and memory caused by reduced magnesium block of NMDA receptors in the D2 receptor expressing cells of the indirect pathway2020

    • Author(s)
      笹岡俊邦, 齊藤奈英, 知見 聡美, 阿部 学, 川村 名子, 鍋島 陽一, 田井中 一貴, 﨑村 建司, 南部 篤
    • Organizer
      第43回神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of alteration in motor control and learning and memory caused by reduced magnesium block of NMDA receptors in the D2 receptor expressing cells of the indirect pathway2020

    • Author(s)
      笹岡俊邦, 齊藤 奈英, 知見 聡美, 阿部 学, 川村 名子, 鍋島 曜子, 鍋島 陽一, 田井中 一貴, 﨑村 建司, 南部 篤
    • Organizer
      第63回日本神経化学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] IDR領域に違いをもつhnRNP A/BバリアントによるmRNA翻訳制御2020

    • Author(s)
      福田 七穂, PERCIPALLE Piergiorgio, CZAPLINSKI Kevin, 福田 智行, 笹岡 俊邦
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子改変マーモセット作製の効率化に向けて:異種卵巣移植によるマーモセット卵子の採取方法の確立2020

    • Author(s)
      中務 胞、 宮本 純、岩崎 亜美、村田 康輔、平山 瑠奈、夏目 里恵、阿部 学、崎村 建司、笹岡 俊邦
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経回路の可視化・操作・モデリングのための最先端技術2020

    • Author(s)
      田井中一貴
    • Organizer
      第3回若手育成セミナー 新学術領域研究
    • Related Report
      2020 Annual Research Report
  • [Presentation] 複雑パターン走行時におけるリズムチャンクの解析2020

    • Author(s)
      広兼 浩二朗, 中村 徹, 久保田 康夫, Hu Dan, 八木 健, Graybiel AM, 木津川 尚史
    • Organizer
      第43回神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 線条体神経細胞によるリズミカルな運動制御2020

    • Author(s)
      木津川 尚史, 寺下 拓真, 広兼 浩二朗, 久保田 康夫, Dan Hu, 八木 健, Graybiel AM, 中村 徹
    • Organizer
      第43回神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子改変マーモセット作製にかかる基盤技術の開発2020

    • Author(s)
      中務胞、宮本純、夏目里恵、_村建司、笹岡俊邦
    • Organizer
      第9回日本マーモセット研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Elucidation of motor control and aversive memory formation mechanism by dopamine using dopamine D1 receptor gene modified mice2020

    • Author(s)
      Nae Saito et al.
    • Organizer
      The 10th BRI International Symposium, ADVANCED BRAIN IMAGING FOR THE FUTURE
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of motor control mechanism by the striatum using genetically modified mice harboring tetracycline-controlled expression of D1/D2 dopamine receptors and activated NMDA receptors in the striatum2019

    • Author(s)
      Toshikuni Sasaoka, Nae Saito, Satomi Chiken, Manabu Abe, Yo-ichi Nabeshima, Kazuki Tainaka, Kenji Sakimura, Atsushi Nambu
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会 サテライトシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Studying the mechanism of motor control using mouse model for Parkinson's disease2019

    • Author(s)
      Toshikuni Sasaoka
    • Organizer
      The 8th Japan-Sino-Korea Mouse Resource Workshop “Precision Modelling of Human Diseases in Mice and Cell Resources”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Research on mechanism of motor control and development of genetically modified animal production technology for higher brain function research2019

    • Author(s)
      Toshikuni Sasaoka
    • Organizer
      Visit by Brain Research Institute,Niigata University, Japan Mini Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 線条体のD2ドーパミン受容体を発現する間接路ニューロンにおけるNMDA受容体のMg2+ブロックの減少により引き起こされる運動異常2019

    • Author(s)
      笹岡俊邦,齊藤奈英, 知見聡美,小田佳奈子,阿部学,鍋島曜子,鍋島陽一, 田井中一貴, 崎村建司, 南部篤
    • Organizer
      新学術領域研究「非線形発振現象を基盤としたヒューマンネイチャーの理解」2019 年度第 1 回領域会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] 嗅神経細胞におけるmRNA 局在化機構の解明2019

    • Author(s)
      福田七穂, 川市正史, 石田靖雅, 福田智行, 笹岡俊邦
    • Organizer
      第60回新潟生化学懇話会
    • Related Report
      2019 Annual Research Report
  • [Presentation] テトラサイクリン調節ドーパミンDl 受容体発現を有する遺伝子改変マウスを用いたドーパミンによる運動制御機構の解明2019

    • Author(s)
      齊藤奈英, 原怜, 田井中一貴, 阿部学, 川村名子, 山口瞬, 知見聡美, 一瀬宏, 崎村建司, 南部篤, 笹岡俊邦
    • Organizer
      第60回新潟生化学懇話会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 最先端発生工学技術の融合による脳神経研究に有用な遺伝子改変動物作製法確立の試み2019

    • Author(s)
      中務胞、夏目里恵、崎村建司、笹岡俊邦、山城秀昭、阿部学
    • Organizer
      第60回新潟生化学懇話会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 片側内耳破壊の皮質神経活動への影響2019

    • Author(s)
      甲斐龍太、 田井中一貴、 高橋邦之、齊藤 奈英、 笹岡 俊邦、 山口 瞬、 那波 宏之、堀井 新
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 線条体のD2ドーパミン受容体発現間接路神経におけるNMDA受容体のマグネシウムブロック低下による運動異常2019

    • Author(s)
      笹岡 俊邦, 齊藤 奈英, 阿部 学, 川村 名子, 鍋島 曜子, 鍋島 陽一, 田井中 一貴, _村 建司
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 結合タンパク質hnRNP A/Bのマウス嗅覚神経細胞における機能の解明2019

    • Author(s)
      福田 七穂, Percipalle Piergiorgio, Czaplinski Kevin, 福田 智行,笹岡 俊邦
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] D1ドーパミン受容体コンディショナル発現マウスを_いたドーパミンによる運動制御機構の解明2019

    • Author(s)
      齊藤 奈英,大久保 朝子, 阿部 学, 川村 名子, 山口 瞬, 一瀬 宏, 崎村 建司, 田井中 一貴, 知見 聡美, 南部 篤, 笹岡 俊邦
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス脳におけるNMDA型 グルタミン酸受容体サブユニットの定量的解析2019

    • Author(s)
      鈴_ 康浩,中本 千尋,阿部 学,笹岡 俊邦,_村 建司
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脊髄小脳失調症42型モデルマウスを用いた神経変性分子病態基盤の解明2019

    • Author(s)
      橋口 俊太,土井 宏,國井 美紗子,中村 行宏,志牟田 美佐 ,鈴木 江津子,大久保 正紀 ,笹岡 俊邦,竹内 英之,石川 太郎,田中 章景
    • Organizer
      第42回神経科学大会 第62回日本神経化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] テトラサイクリン調節ドーパミンD1受容体発現を有する遺伝子改変マウスを用いたドーパミンによる運動制御機構の解明2019

    • Author(s)
      笹岡 俊邦, 齊藤 奈英, 原怜, 田井中 一貴, 知見 聡美, 阿部 学, 川村 名子, 山口 瞬, 鍋島陽一, 一瀬 宏, _村 建司, 南部 篤
    • Organizer
      第66回中部日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of functions of the basal ganglia circuit using dopamine receptor and NMDA receptor mutant mice.2019

    • Author(s)
      Nae Saito, Kazuki Tainaka, Satomi Chiken, Satoshi Hara, Manabu Abe, Meiko Kawamura, Yoko Nabeshima, Yo-ichi Nabeshima, Shun Yamaguchi, Hiroshi Ichinose, Kenji Sakimura, Atsushi Nambu, Toshikuni Sasaoka
    • Organizer
      神経オシレーションカンファレンス2019「ヒューマンネイチャーの理解」
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] テトラサイクリン調節ドーパミンD1受容体発現を有する遺伝子改変マウスを用いたドーパミンによる運動制御機構の解明2019

    • Author(s)
      笹岡 俊邦, 齊藤 奈英, 原怜, 田井中 一貴, 阿部 学, 川村 名子, 山口 瞬, 知見 聡美,一瀬 宏, _村 建司, 南部 篤
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ドーパミン受容体及びNMDA受容体変異マウスを用いた大脳基底核回路の機能解析2019

    • Author(s)
      笹岡 俊邦, 齊藤 奈英, 原 怜, 田井中 一貴, 阿部 学, 川村 名子, 山口 瞬, 知見 聡美,一瀬 宏, _村 建司, 南部 篤 ドーパミン受容体及びNMDA受容体変異マウスを用いた大脳基底核回路の機能解析
    • Organizer
      新学術領域研究「非線形発振現象を基盤としたヒューマンネイチャーの理解」2019 年度第 2回領域会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] テトラサイクリン調節ドーパミンD1受容体発現を有する遺伝子改変マウスを用いたドーパミンによる記憶及び運動制御機構の解明2019

    • Author(s)
      齊藤 奈英, 田井中 一貴, 知見 聡美, 原怜, 山口 瞬, 一瀬 宏, 南部 篤, 笹岡 俊邦
    • Organizer
      新学術領域研究「非線形発振現象を基盤としたヒューマンネイチャーの理解」2019 年度第 2回領域会議
    • Related Report
      2019 Annual Research Report
  • [Presentation] CUBIC: Whole-brain/body imaging with single-cell resolution using hydrophilic chemical cocktails2019

    • Author(s)
      Kazuki Tainaka
    • Organizer
      International Symposium of Biofunctional Chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CUBIC:生体組織透明化による包括的3Dイメージング技術2019

    • Author(s)
      田井中一貴
    • Organizer
      新潟医学会特別講演
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CUBIC: 組織透明化技術による3Dイメージング2019

    • Author(s)
      田井中一貴
    • Organizer
      第60回新潟生化学懇話会プログラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 3D 神経病理学に向けたホールマウント染色手法の開発2019

    • Author(s)
      田井中 一貴・齋藤 理恵・井上 雅文・柿田 明美
    • Organizer
      第60回日本神経病理学会総会学術研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Comprehensive 3D Imaging by Tissue Clearing Technique CUBIC2019

    • Author(s)
      Kazuki Tainaka
    • Organizer
      Neuro2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 組織透明化による3D神経病理学2019

    • Author(s)
      田井中一貴
    • Organizer
      第16回 日本病理学会カンファレンス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] CUBIC: Whole-organ, whole-body imaging with single-cell resolution using chemical cocktails2019

    • Author(s)
      Kazuki Tainaka
    • Organizer
      リエゾンラボ炎症シンポジウムin北海道大学
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 有機化学が拓く次世代3D組織化学2019

    • Author(s)
      田井中一貴
    • Organizer
      第5回 北海道大学部局横断シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The function of the striatum in stepping2019

    • Author(s)
      Takashi Kitsukawa
    • Organizer
      第42回日本神経科学大会 サテライトシンポジウム “Basal Ganglia in Health and Disease”
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The striatal function in rhythmical stepping of mice2019

    • Author(s)
      Takashi Kitsukawa
    • Organizer
      第42回日本神経科学大会 シンポジウム“New Understanding of Functions of Basal Ganglia in Health and Disease”
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] マウスステップにおけるリズミカルなチャンクの形成2019

    • Author(s)
      木津川尚史
    • Organizer
      第29回日本時間生物学会  シンポジウム「生物の多様な集団発振現象」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Elucidation of motor control mechanism using genetically modified mice harboring tetracycline regulated expression of D1/D2 dopamine receptors2019

    • Author(s)
      齊藤奈英、知見聡美、大久保朝子、阿部学、川村名子、山口瞬、崎村建司、田井中一貴、南部篤、笹岡俊邦
    • Organizer
      第8回生理研-霊長研-脳研合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Control of mRNA translation by hnRNP A/B variants2019

    • Author(s)
      Nanaho Fukuda, Piergiorgio Percipalle, Kevin Czaplinski, Yasumasa Ishida, Tomoyuki Fukuda, and Toshikuni Sasaoka
    • Organizer
      第8回生理研-霊長研-脳研合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 異種間移植マーモセット卵巣由来卵子による受精卵作出法の検討2019

    • Author(s)
      中務胞、宮本純、藤澤信義、夏目里恵、三浦詩織、阿部学、三輪美樹、中村克樹、崎村建司、笹岡俊邦
    • Organizer
      第8回生理研-霊長研-脳研合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新潟大学における中型実験動物の飼育管理と利用2019

    • Author(s)
      "三浦詩織、藤澤信義、宮本純、小田佳奈子、福田七穂、内山澄香、 田中稔、山本美丘、作間赳法、阿部光寿、齊藤奈英、鈴木康浩、 中務胞、夏目里恵、小林隆、三浦宏平 、崎村健司、若井俊文、 笹岡俊邦"
    • Organizer
      第8回生理研-霊長研-脳研合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] ドーパミン受容体及びNMDA受容体変異マウスを用いた大脳基底核回路の機 能解析2018

    • Author(s)
      笹岡 俊邦, 佐藤 朝子, 知見 聡美, 大久保 直, 齊藤 奈英, 福田七穂, 内山 澄香, 作間 赳法, 阿部 光寿, 田中 稔, 山本 美丘, 三浦詩織, 阿部 学, 川村 名子, 小田 佳奈子, 佐藤 俊哉, 岡本浩嗣, 藤澤 信義, 田井中一貴, 崎村 建司, 南部 篤
    • Organizer
      科学研究費補助金「新学術領域研究(研究領域提案型)」 非線形発振現象を基盤としたヒューマンネイチャーの理解「オシロロジー」 2018 年度第 1 回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明2018

    • Author(s)
      笹岡 俊邦, 佐藤 朝子, 知見 聡美, 大久保 直, 阿部 学, 川村 名子, 齊藤 奈英, 小田 佳奈子, 作間 赳法, 内山 澄香, 阿部 光寿, 田中 稔, 山本 美丘, 神保 幸弘, 佐藤 俊哉, 藤澤 信義, 崎村 建司, 南部 篤
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] hnRNP A/Bバリアントによる mRNA局在化の制御2018

    • Author(s)
      福田 七穂、石田 靖雅、福田 智行、笹岡 俊邦
    • Organizer
      "第41回日本分子生物学会年会 ワークショップ 新たな機能が明らかになる RNA結合タンパク質の生物学―原 子・分子レベルの解析から神経機能と臨床応用まで―"
    • Related Report
      2018 Annual Research Report
  • [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明2018

    • Author(s)
      笹岡 俊邦、佐藤 朝子、知見 聡美、大久保 直、齊藤 奈英、福田 七穂、阿部 学、川村 名子、小田 佳奈子、佐藤 俊哉、藤澤 信義、山口 瞬、田井中 一貴、崎村 建司、南部 篤
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明2018

    • Author(s)
      笹岡 俊邦、齊藤 奈英、知見 聡美、佐藤 朝子、大久保 直、福田 七穂、阿部 学、川村 名子、小田 佳奈子、佐藤 俊哉、藤澤 信義、山口 瞬、田井中 一貴、崎村 建司、南部 篤
    • Organizer
      平成30年度先端モデル動物支援プラットフォーム 成果発表会
    • Related Report
      2018 Annual Research Report
  • [Book] 『病理と臨床』組織・細胞の透明化2020

    • Author(s)
      田井中一貴
    • Total Pages
      4
    • Publisher
      文光堂
    • Related Report
      2019 Annual Research Report
  • [Book] 『ぶんせき』入門講座 組織透明化技術と蛍光顕微鏡 3D イメージング2019

    • Author(s)
      田井中一貴
    • Total Pages
      8
    • Publisher
      公益社団法人 日本分析化学会
    • Related Report
      2019 Annual Research Report
  • [Book] 標準生理学第9版2019

    • Author(s)
      南部篤
    • Publisher
      医学書院
    • ISBN
      9784260034296
    • Related Report
      2019 Annual Research Report
  • [Remarks] 新潟大学脳研究所 動物資源開発研究分野 ホームページ

    • URL

      https://www.bri.niigata-u.ac.jp/field/lab_animal/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 新潟大学脳研究所 研究成果・実績 ホームページ

    • URL

      https://www.bri.niigata-u.ac.jp/research/result/lab_animal/001414.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 新潟大学脳研究所 研究成果・実績 ホームページ

    • URL

      https://www.bri.niigata-u.ac.jp/research/result/lab_animal/001415.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 新潟大学脳研究所 概要

    • URL

      https://www.bri.niigata-u.ac.jp/about/prbook/overview2020.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 新潟大学脳研究所 年報

    • URL

      https://www.bri.niigata-u.ac.jp/about/prbook/report_2019.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 新潟大学脳研究所 脳研コラム ホームページ

    • URL

      http://www.bri.niigata-u.ac.jp/result/lab_animal/000126.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 新潟大学脳研究所 研究成果・実績 ホームページ

    • URL

      http://www.bri.niigata-u.ac.jp/result/lab_animal/000833.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 新潟大学脳研究所 動物資源開発研究分野 ホームページ

    • URL

      http://www.bri.niigata-u.ac.jp/field/lab_animal/index.html

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] イスラエル特許2019

    • Inventor(s)
      南部 篤、知見聡美、西村幸男、高良紗幸
    • Industrial Property Rights Holder
      自然科学研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 米国特許2019

    • Inventor(s)
      南部 篤、知見聡美、西村幸男、高良紗幸
    • Industrial Property Rights Holder
      自然科学研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Funded Workshop] 第42回日本神経科学大会 サテライトシンポジウム “Basal Ganglia in Health and Disease”2019

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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