| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Avian nucleus magnocellularis is a homologue of mammalian anteroventral cochlear nucleus, and represents temporal information of sound with great precision. This precision is accomplished by tonotopic specializations in synaptic and postsynaptic properties. To achieve better understanding on these specializations, we first examined properties of inhibitory synapses, and found that they were differentiated in number and size along the tonotopic axis, ensuring precise and reliable signal processing across frequencies and intensities. We next examined expressions of Nav and Kv channels during development, and found that their expressions were strongly accelerated via auditory input specifically in neurons tuned to higher-frequency sound. This occurred because the activity-dependent mechanism was more efficient in the neurons, proposing a concept that both neuronal tonotopic identity and pattern of afferent input are critical for the tonotopic specializations.
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