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Tonotopic differentiations in central auditory circuit

Research Project

Project/Area Number 18H02541
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionNagoya University

Principal Investigator

Kuba Hiroshi  名古屋大学, 医学系研究科, 教授 (10362469)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords聴覚 / 神経回路 / 神経活動 / 中枢神経回路
Outline of Final Research Achievements

Avian nucleus magnocellularis is a homologue of mammalian anteroventral cochlear nucleus, and represents temporal information of sound with great precision. This precision is accomplished by tonotopic specializations in synaptic and postsynaptic properties. To achieve better understanding on these specializations, we first examined properties of inhibitory synapses, and found that they were differentiated in number and size along the tonotopic axis, ensuring precise and reliable signal processing across frequencies and intensities. We next examined expressions of Nav and Kv channels during development, and found that their expressions were strongly accelerated via auditory input specifically in neurons tuned to higher-frequency sound. This occurred because the activity-dependent mechanism was more efficient in the neurons, proposing a concept that both neuronal tonotopic identity and pattern of afferent input are critical for the tonotopic specializations.

Academic Significance and Societal Importance of the Research Achievements

音の時間情報を幅広い周波数域で正確に処理することは、聴覚の機能発現に不可欠である。本研究では、この幅広い周波数域での正確な聴覚情報処理の神経回路基盤を明らかにするとともに、その形成過程における細胞特性と聴覚入力の連関の重要性について示した。これらの知見は、中枢聴覚回路の機能最適化という観点から今後の難聴治療戦略に新たな可能性を提示するだけでなく、様々な感覚系でみられる活動依存的な回路成熟、さらには脳部位特異的な回路成熟の仕組みを理解する上でも重要な示唆を与えると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Structural and functional refinement of the axon initial segment in avian cochlear nucleus during development2020

    • Author(s)
      Nargis Akter, Ryota Fukaya, Ryota Adachi, Hiroshi Kawabe, Hiroshi Kuba
    • Journal Title

      The Journal of Neuroscience

      Volume: 40 Issue: 35 Pages: 6709-6721

    • DOI

      10.1523/jneurosci.3068-19.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 特集 脳神経回路のダイナミクスから探る脳の発達・疾患・老化 軸索コンパートメントの構造可塑性と聴覚チューニング2019

    • Author(s)
      久場 博司
    • Journal Title

      生体の科学

      Volume: 70 Issue: 1 Pages: 19-22

    • DOI

      10.11477/mf.2425200940

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2019-02-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excitatory and Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis2019

    • Author(s)
      Al-Yaari Mohammed、Yamada Rei、Kuba Hiroshi
    • Journal Title

      The Journal of Neuroscience

      Volume: 40 Issue: 3 Pages: 619-631

    • DOI

      10.1523/jneurosci.1124-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tonotopic Differentiation of Coupling between Ca2+ and Kv1.1 Expression in Brainstem Auditory Circuit.2019

    • Author(s)
      Adachi R, Yamada R, Kuba H.
    • Journal Title

      iScience

      Volume: 13 Pages: 199-213

    • DOI

      10.1016/j.isci.2019.02.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of neuronal excitability at the axon initial segment2018

    • Author(s)
      久場博司
    • Journal Title

      生化学

      Volume: 90 Issue: 1 Pages: 69-74

    • DOI

      10.14952/SEIKAGAKU.2018.900069

    • NAID

      40021492936

    • ISSN
      0037-1017
    • Year and Date
      2018-02-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dendritic synapse geometry optimizes binaural computation in sound localization circuit2021

    • Author(s)
      Kuba H
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Regulation of ion channel expression in brainstem auditory circuit2020

    • Author(s)
      Kuba H
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Tuning of excitable axonal domains in central auditory neurons2018

    • Author(s)
      Kuba H
    • Organizer
      Axon in the hills
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Activity-dependent tuning of Kv1.1 expression in brainstem auditory circuit2018

    • Author(s)
      Kuba H
    • Organizer
      第41回日本神経科学大会(神戸)
    • Related Report
      2018 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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