Analysis of basal ganglia circuit mechanisms in cognitive learning and psychiatric disorders
| Project/Area Number |
18H02542
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 46030:Function of nervous system-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 大脳基底核 / 認知学習 / 神経回路 / 神経伝達 / 側坐核 / 大脳皮質 / 行動柔軟性 / 精神疾患 / 社会的孤立 / 遺伝-環境相互作用 / ドーパミン / 神経科学 / 脳・神経 / 脳神経疾患 / トランスレーショナルリサーチ / 生理学 / 大脳皮質内側前頭前野 / 認知行動 / 腹側淡蒼球 |
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| Outline of Final Research Achievements |
Basal ganglia circuit-specific manipulation revealed that the direct and indirect pathway of the nucleus accumbens is specifically involved in Pavlovian cognitive learning and reversal learning, respectively. We also found that the ventral pallidum is important for aversive learning. In addition, the direct and indirect pathways of the nucleus accumbens regulate circuit-specific gene expression in the medial prefrontal cortex. The mouse model of psychiatric disorders showed molecular pathology specific in the nucleus accumbens, indicating a role for the basal ganglia circuit in the pathogenesis of psychiatric disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、認知学習における大脳皮質-大脳基底核神経回路の制御機構が明らかとなった。また精神疾患モデルマウスの解析により、精神疾患病態において大脳基底核神経回路の異常をもたらす分子病態が関与していることが明らかとなった。これらの研究成果は、神経回路に着目した新しい精神疾患治療法の開発につながるものである。
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry2022
Author(s)
Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 76
Issue: 1
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vrk2 deficiency elicits aggressive behavior in female zebrafish2022
Author(s)
Umeda Ryohei、Teranishi Hitoshi、Hada Kazumasa、Shimizu Nobuyuki、Shiraishi Hiroshi、Urushibata Hirotaro、Lai Shaohong、Shide Masahito、Carrasco Apolinario Magdeline E.、Higa Ryoko、Shikano Kenshiro、Shin Toshitaka、Mimata Hiromitsu、Hikida Takatoshi、Hanada Toshikatsu、Hanada Reiko
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Journal Title
Genes to Cells
Volume: 27(4)
Issue: 4
Pages: 254-265
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice2021
Author(s)
Sakurai Koki, Itou Taichi, Morita Makiko, Kasahara Emiko, Moriyama Tetsuji, Macpherson Tom, Ozawa Takaaki, Miyamoto Yoichi, Yoneda Yoshihiro, Sekiyama Atsuo, Oka Masahiro, Hikida Takatoshi
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Journal Title
PLOS ONE
Volume: 16
Issue: 11
Pages: e0258364-e0258364
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation.2019
Author(s)
Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, Furuhashi M, Morita M, Sato T, Hirose S, Ohkawa Y, Yoshimura Y, Hikida T, Furukawa T.
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Journal Title
Sci Rep.
Volume: Mar 5;9(1)
Issue: 1
Pages: 3445-3445
DOI
NAID
Related Report
Peer Reviewed / Open Access
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