| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|
|---|
| Outline of Final Research Achievements |
Basal ganglia circuit-specific manipulation revealed that the direct and indirect pathway of the nucleus accumbens is specifically involved in Pavlovian cognitive learning and reversal learning, respectively. We also found that the ventral pallidum is important for aversive learning. In addition, the direct and indirect pathways of the nucleus accumbens regulate circuit-specific gene expression in the medial prefrontal cortex. The mouse model of psychiatric disorders showed molecular pathology specific in the nucleus accumbens, indicating a role for the basal ganglia circuit in the pathogenesis of psychiatric disorders.
|
