Experience-dependent development of intercortical neuronal connections in the visual cortex

• Project/Area Number: 18H02547
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 46030:Function of nervous system-related
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: Yoshimura Yumiko 生理学研究所, 基盤神経科学研究領域, 教授 (10291907)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 大脳皮質視覚野 / 興奮性細胞 / 活動同期性 / 空間周波数選択性 / 方位選択性 / 抑制性細胞 / 経験依存的発達 / 領野間神経結合 / 形態視 / 運動視 / 領域間神経結合

Outline of Final Research Achievements

Early visual experience is essential for the maturation of visual cortical functions. The extraction of visual features based on response selectivity of individual neurons, a fundamental process in the cortex, is basically established by eye opening, suggesting that visual experience is required for the development of neural functions other than feature extraction. We show that synchronized firing, important for visual information processing, is selectively established between adjacent neurons sharing similar visual preferences in layers 2-4 after pattern vision. In contrast, synchronization weakly depending on response similarity developed in layer 5-6 neurons almost independently of visual experience. These results suggest that upper layer synchronization conveys information necessary for form perception to the higher-order cortex, whereas lower layer synchronization coveys information necessary for visually-guided innate behavior to the subcortical areas.

Academic Significance and Societal Importance of the Research Achievements

脳機能の発現に必要な神経回路は、胎生期から生後間もない時期に遺伝的プログラムにより大まかに形成され、その後、経験や学習に依存して柔軟に再構築される。このプロセスを経て、生まれ育った環境に適した機能が獲得される。本研究は、大脳皮質の多細胞の活動同期性を特徴づけ、その発達機構を明らかにしたもので、その成果により生後の経験に依存した脳機能発達メカニズムの理解に貢献できると考えられる。

Research Products

• [Journal Article] Long-Range Interhemispheric Projection Neurons Show Biased Response Properties and Fine-Scale Local Subnetworks in Mouse Visual Cortex (2021)
  • Author(s): Kenta M Hagihara, Ayako Wendy Ishikawa, Yumiko Yoshimura, Yoshiaki Tagawa, Kenichi Ohki
  • Journal Title: Cerebral Cortex Volume: 31 Issue: 2 Pages: 1307-1315
  • DOI: 10.1093/cercor/bhaa297
  • Peer Reviewed / Open Access
• [Journal Article] Developmental Phase Transitions in Spatial Organization of Spontaneous Activity in Postnatal Barrel Cortex Layer 4. (2020)
  • Author(s): Nakazawa, S., Yoshimura, Y., Takagi M., Mizuno H. & Iwasato T.
  • Journal Title: J Neurosci. Volume: 2020 Sep 4;JN-RM Issue: 40 Pages: 1116-1120
  • DOI: 10.1523/jneurosci.1116-20.2020
  • Peer Reviewed / Open Access
• [Journal Article] Hypothalamic Neuronal Circuits Regulating Hunger-Induced Taste Modification (2019)
  • Author(s): Fu O, Iwai Y, Narukawa M, Ishikawa AW, Ishii KK, Murata K, Yoshimura Y, Touhara K, Misaka T, Minokoshi Y, Nakajima KI.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 4560-4560
  • DOI: 10.1038/s41467-019-12478-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation. (2019)
  • Author(s): Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, Furuhashi M, Morita M, Sato T, Hirose S, Ohkawa Y, Yoshimura Y, Hikida T, Furukawa T.
  • Journal Title: Sci Rep. Volume: Mar 5;9(1) Issue: 1 Pages: 3445-3445
  • DOI: 10.1038/s41598-019-38910-2
  • NAID: 120006579467
  • Peer Reviewed / Open Access
• [Journal Article] Experience-Dependent Development of Feature-Selective Synchronization in the Primary Visual Cortex (2018)
  • Author(s): Ishikawa Ayako Wendy、Komatsu Yukio、Yoshimura Yumiko
  • Journal Title: The Journal of Neuroscience Volume: 38 Issue: 36 Pages: 7852-7869
  • DOI: 10.1523/jneurosci.0027-18.2018
  • Peer Reviewed
• [Journal Article] Length of myelin internodes of individual oligodendrocytes is controlled by microenvironment influenced by normal and input-deprived axonal activities in sensory deprived mouse models (2018)
  • Author(s): Osanai Yasuyuki、Shimizu Takeshi、Mori Takuma、Hatanaka Nobuhiko、Kimori Yoshitaka、Kobayashi Kenta、Koyama Shinsuke、Yoshimura Yumiko、Nambu Atsushi、Ikenaka Kazuhiro
  • Journal Title: Glia Volume: 66 Issue: 11 Pages: 2514-2525
  • DOI: 10.1002/glia.23502
  • Peer Reviewed / Open Access
• [Journal Article] Higher primate-like direct corticomotoneuronal connections are transiently formed in a juvenile subprimate mammal (2018)
  • Author(s): Murabe Naoyuki、Mori Takuma、Fukuda Satoshi、Isoo Noriko、Ohno Takae、Mizukami Hiroaki、Ozawa Keiya、Yoshimura Yumiko、Sakurai Masaki
  • Journal Title: Scientific Reports Volume: - Issue: 1 Pages: 16536-16536
  • DOI: 10.1038/s41598-018-34961-z
  • Peer Reviewed / Open Access
• [Presentation] 方位弁別学習後のラット一次視覚野に見られる低コントラスト優位な神経活動 (2021)
  • Author(s): 木村梨絵, 吉村由美子
  • Organizer: 第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
• [Presentation] 大脳皮質視覚野の経験依存的発達メカニズム (2020)
  • Author(s): 吉村由美子
  • Organizer: 第43回日本神経科学大会
• [Presentation] 同一神経細胞の麻酔、覚醒下における空間周波数応答特性の変化 (2020)
  • Author(s): 呉 嘉豪, 米田 泰輔, 吉村 由美子
  • Organizer: 第43回日本神経科学大会
• [Presentation] 方位弁別時に機能する低コントラスト優位な一次視覚野細胞の生成メカニズム. (2019)
  • Author(s): 木村梨絵, 吉村由美子
  • Organizer: 第42回日本神経科学大会
• [Presentation] マウス一次視覚野におけるFast spiking抑制性細胞－錐体細胞間結合の発達. (2019)
  • Author(s): 山本真理子, 岩里琢治, 吉村由美子
  • Organizer: 第42回日本神経科学大会
• [Presentation] Establishment of clustered protocadherin-regulated high reciprocal connectivity between clonal cortical neurons requires sensory experience in mouse barrel cortex. (2019)
  • Author(s): Tarusawa E. Sanbo M, Hirabayashi T, Yagi Y, Yoshimura Y
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] The roles of visual experience in the maturation of secondary visual cortex. (2018)
  • Author(s): Yoshimura Y
  • Organizer: The 95th Annual Meeting of the Physiological Society Meeting
  • Invited
• [Presentation] Clustered protocadherins-regulated high reciprocal connectivity between clonal cortical neurons are selectively modified by short sensory deprivation in mouse barrel cortex. (2018)
  • Author(s): Tarusawa E, Sanbo M, Hirabayashi M, Yagi T, Yoshimura Y
  • Organizer: Neuro2018
  • Int'l Joint Research