| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
In this study, we have examined systematic research on organic synthesis methods focusing on dearomatization and rearomatization processes to develop new organic chemistry technologies that will contribute to the promotion of pharmaceutical research. In particular, we have succeeded in developing various dearomatization reactions and direct conversion reactions of stable bonds based on new reactivity of silver carbene and other metal carbene species, developing new synthetic methods for 3,4-fused tricyclic indoles and benzofurans using transition metal catalysis and radical reactions, developing synthetic methods for biologically active natural products, and analyzing detailed reaction mechanisms of developed methods using DFT calculations.
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