| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Outline of Final Research Achievements |
This research project aimed to create functions by creating regular structures in molecules. It is a linkage between the establishment of the basic science of "structural organic chemistry" to construct molecules that mimic biological ligands and the "science of function creation" for application to medicinal chemistry and chemical biology. The hypothesis of this research was evaluated by obtaining actual bioactive substances in addition to basic research in structural organic chemistry. In particular, we demonstrated that it is possible to dynamically fix the cis-trans equilibrium of tertiary amide bonds with high structural flexibility and easy rotation, and we found in vivo to construct robust regular structures and regulate protein-protein interactions.
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