| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
We have recently invented a catalyst V-MPS4 with oxovanadium immobilized on the pore surface of mesoporous silica and achieved dynamic kinetic resolution (DKR) of racemic secondary alcohols by simultaneously using V-MPS4 and lipases in a single flask. This method can convert racemic secondary alcohols to optically pure esters at nearly 100% efficiency. The purpose of this study is to extend our findings to two groups of compounds, alcohols and axially chiral biaryls.
The following three types of new reactions were developed: (1) Enantio-divergent DKR of propargylic alcohols to produce both enantiomers in high yields and high optical purity, (2) DKR of tertiary alcohols, and (3) Asymmetric synthesis of axially chiral biaryl compounds.
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