| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Deamination of mRNA bases has been known for a long time as an editing reaction. Chemical modifications such as methylation have recently been revealed to play important roles in regulation of translation. We have succeeded in developing chemically reactive artificial nucleic acids that induce functional group transfer by forming hybrid complexes with RNA, resulting in site-specific and base-specific chemical modifications. In this study, we used this reaction to chemically modify mRNA in a site-specific manner in order to realize the editing function. The results of this research will lead to the creation of new nucleic acid drugs with editing functions targeting mRNA.
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