| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
The strict regulation of duration and intensity of activation of the stress response signaling is required for the induction of appropriate responses to various types of internal and external stress, and its failure causes cellular dysfunction and various diseases. However, the molecular mechanisms of the regulation are not well understood. In this study, we found that the balance of the stress response signaling is actually regulated and fine-tuned through the crosstalk (cooperative and reciprocal interaction) between various post-translational modifications, such as ubiquitination, for kinases as signaling molecules essential for the induction of stress responses, including cell death and inflammation, and that the disorder of the balance could lead to the onset of cancer and autoimmune diseases.
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