| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Dementia and diabetes are thought to be caused by the effects of environmental factors such as lifestyle and internal genetic factors along a long-term time axis. In this study, we aimed to elucidate the mechanisms by which environmental factors and time axis lead to diabetes and dementia via abnormalities in energy metabolism regulatory mechanisms including the Notch pathway, using zebrafish and Drosophila as models. We found that the regulation of glycolytic genes via Notch signaling is context-dependent during development, and that the decline in metabolic rate with aging is not due to energy imbalance but mostly to the aging program.
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