| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
The followings were clarified in this study.
(1) Phosphoinositide-metabolizing enzyme PLCg1 is required for the normal formation of sebaceous glands. (2)Phosphoinositide-metabolizing enzymes PLCg1 and PLCd1 regulate the severity of mouse models for inflammatory skin diseases. (3) PI-PLC, phosphatidylinositol-metabolizing enzyme of S. aureus, promoted the penetration of S. aureus through the epidermal barrier in a mouse model of atopic dermatitis and the human organotypic epidermal equivalent. (4) In keratinocytes, PI(4,5)P2 is proximal to epithelial junctional proteins, and PI(4,5)P2 is required for plasma membrane accumulation of these proteins.
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