| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Outline of Final Research Achievements |
Marine sponges are sessile animals harboring vast array of symbiont microorganisms. They inhabit in global oceans and the number of species are estimated to be 10,000. More than 20,000 bioactive natural products have been isolated from the marine sponges thus far. The search based on the randam screening is so common that cytotoxic compounds has been dominated and some of them exhibit significantly potent cytotoxicity with pM range of concentration. However, due to the scarcity and highly complex structure, most of them had not been developed to clinically useful anti-cancer agents. On the other hand, it has been suggested that many sponge-derived cytotoxins are produced by symbiont bacteria. In this study, we implanted the search for biosynthetic gene cluster of sponge-derived bioactive molecules and detailed analysis of biosynthetic pathway, and identification of producer symbiont.
|
