Development of renal protection-oriented immunosuppressive therapy after organ transplantation utilizing mTOR inhibitor

• Project/Area Number: 18H02588
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Himeji Dokkyo University (2020-2021); International University of Health and Welfare (2019); Kyushu University (2018)
• Principal Investigator: Masuda Satohiro 姫路獨協大学, 薬学部, 教授 (90303825)
• Co-Investigator(Kenkyū-buntansha): 吉住 朋晴 九州大学, 医学研究院, 准教授 (80363373) ; 岡部 安博 九州大学, 大学病院, 助教 (90444819) ; 田島 壮一郎 九州大学, 大学病院, 薬剤師 (10579460)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 免疫抑制薬 / 副作用 / 有害反応 / 移植 / バイオマーカー / mTOR / カルシニューリン阻害薬 / 遺伝子多型 / 腎臓移植 / 肝臓移植 / 腎障害 / mTOR阻害薬 / 医療薬剤学 / 薬物動態学 / 移植免疫医学 / 免疫抑制役

Outline of Final Research Achievements

Chronic allograft nephrotoxicity induced by calcineurin inhibitors has been also raised as a severe problem in the transplant patients receiving these drugs. The renal fibrosis model rats using the treatment of ischemia-reperfusion injury with daily administration of tacrolimus, coadministration of mTOR inhibitor everolimus suppressed the progression of interstitial fibrosis in comparison with the tacrolimus alone. In clinical cases, the pharmacokinetic monitoring of the sum of the trough concentrations of tasrolimus and everolimus seems to be easier than that of the conventional separate monitoring of tacrolimus and everolimus, respectively. These results suggest that the present pharmacokinetic monitoring such as sum of each trough measurement of tacrolimus and everolimus is useful in posttransplant immunosuppressive therapy obtaining the decreasing tacrolimus-induced CNI-induced renal interstitial fibrosis by the pharmacological effect of mTOR inhibitor after organ transplantation.

Academic Significance and Societal Importance of the Research Achievements

臓器移植後の免疫抑制療法において、カルシニューリン阻害薬（タクロリムス、シクロスポリン ）は移植臓器の生着率を著しく向上させてきたが、組織の線維化という病理像を示す毒性を引き起こすことが問題とされてきた。今回、新しいクラスのmTOR阻害薬を併用することにより、タクロリムスの用量を抑制し、移植術後の腎毒性を軽減するための新たなモニタリング戦略を構築することができた。さらに、mTOR阻害薬の併用はタクロリムスによって引き起こされた組織の線維化領域の削減にも効果を示した。これらの結果は、臓器移植術を受けた患者の術後腎機能低下という合併症を回避し、QOL向上に役立つものと考える。

Research Products

• [Int'l Joint Research] Harvard Institute of Medicine/Cincinnati Children's Hospital(米国)
• [Int'l Joint Research] Fischer-Bosch Institute(ドイツ)
• [Int'l Joint Research] Harvard Institute of Medicine/Cincinnati Children's Hospital(米国)
• [Int'l Joint Research] Fischer-Bosch Institute(ドイツ)
• [Int'l Joint Research] Harvard Institute of Medicine/Cincinnati Children's Hospital(米国)
• [Int'l Joint Research] Fischer-Bosch Institute(ドイツ)
• [Journal Article] Effect of Itraconazole and Its Metabolite Hydroxyitraconazole on the Blood Concentrations of Cyclosporine and Tacrolimus in Lung Transplant Recipients (2022)
  • Author(s): Matsuda Yuya、Nakagawa Shunsaku、Yano Ikuko、Masuda Satohiro、Imai Satoshi、Yonezawa Atsushi、Yamamoto Takashi、Sugimoto Mitsuhiro、Tsuda Masahiro、Tsuzuki Tetsunori、Omura Tomohiro、Nakagawa Takayuki、Chen-Yoshikawa Toyofumi Fengshi、Nagao Miki、Date Hiroshi、Matsubara Kazuo
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 45 Issue: 4 Pages: 397-402
  • DOI: 10.1248/bpb.b21-00738
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  • Year and Date: 2022-04-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibitory effects of vandetanib on creatinine transport via renal organic cation transporter OCT2 (2021)
  • Author(s): Tanihara Yuko、Masuda Satohiro、Inui Ken-ichi
  • Journal Title: European Journal of Pharmaceutical Sciences Volume: 158 Pages: 105666-105666
  • DOI: 10.1016/j.ejps.2020.105666
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• [Journal Article] Establishment of an experimental rat model of tacrolimus-induced kidney injury accompanied by interstitial fibrosis (2021)
  • Author(s): Fu Rao、Tajima Soichiro、Shigematsu Tomohiro、Zhang Mengyu、Tsuchimoto Akihiro、Egashira Nobuaki、Ieiri Ichiro、Masuda Satohiro
  • Journal Title: Toxicology Letters Volume: 341 Pages: 43-50
  • DOI: 10.1016/j.toxlet.2021.01.020
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• [Journal Article] Continuous monitoringof neutrophils to lymphocytes ratio for estimating the onset, severity, and subsequent prognosis of immune related adverse events (2021)
  • Author(s): Ryosuke Matsukane, Hiroyuki Watanabe, Haruna Minami, Kojiro Hata, Kimitaka Suetsugu, Toshikazu Tsuji, Satohiro Masuda, Isamu Okamoto, Takashi Nakagawa, Takamichi Ito, Masatoshi Eto, Masaki Mori, Yoichi Nakanishi, Nobuaki Egashira
  • Journal Title: Sci Rep Volume: 11(1), 1324 Issue: 1 Pages: 1324-1324
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• [Journal Article] Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (2021)
  • Author(s): Bergan S, Brunet M, Hesselink DA, Masuda S, Millan O, Mizuno T, Moes DJAR, Oellerich M, Picard N, Salzmann L, Tönshoff B, van Schaik RHN, Vethe NT, Vinks AA, Wallemacq P, Åsberg A & Langman LJ, and 21 authors
  • Journal Title: Therapeutic Drug Monitoring Volume: 43 Issue: 2 Pages: 150-200
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• [Journal Article] Effects of Concomitant Administration of Vonoprazan Fumarate on the Tacrolimus Blood Concentration in Kidney Transplant Recipients (2020)
  • Author(s): Mei Takanori、Noguchi Hiroshi、Suetsugu Kimitaka、Hisadome Yu、Kaku Keizo、Okabe Yasuhiro、Masuda Satohiro、Nakamura Masafumi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 10 Pages: 1600-1603
  • DOI: 10.1248/bpb.b20-00361
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  • Year and Date: 2020-10-01
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• [Journal Article] Significant Changes Associated with the Transition from Outsourcing to In-hospital Therapeutic Drug Monitoring of Novel Antiepileptics (2020)
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  • Journal Title: YAKUGAKU ZASSHI Volume: 140 Issue: 8 Pages: 1035-1040
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• [Journal Article] Effects of Diluent Volume and Administration Time on the Incidence of Anaphylaxis Following Docetaxel Therapy in Breast Cancer (2020)
  • Author(s): Ishida Shigeru、Masuguchi Ken、Kawashiri Takehiro、Tsuji Toshikazu、Watanabe Hiroyuki、Akiyoshi Sayuri、Kubo Makoto、Masuda Satohiro、Egashira Nobuaki
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 4 Pages: 663-668
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• [Journal Article] Statin Intolerance Clinical Guide 2018 (2020)
  • Author(s): Kajinami K, Tsukamoto K, Koba S, Inoue I, Yamakawa M, Suzuki S, Hamano T, Saito H, Saito Y, Masuda S, Nakayama T, Okamura T, Yamashita S, Kagawa T, Kaneyama J, Kuriyama A, Tanaka R, Hirata A: Statin Intolerance Clinical Guide Working Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 27 Issue: 4 Pages: 375-396
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• [Journal Article] Increasing Diluent Volume Decreases Bendamustine-Induced Venous Irritation without Reducing the Therapeutic Efficacy (2020)
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  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 3 Pages: 488-492
  • DOI: 10.1248/bpb.b19-00826
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  • Year and Date: 2020-03-01
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• [Journal Article] Use of Mycophenolate Mofetil Suspension as Part of Induction Therapy After Living-Donor Liver Transplant (2020)
  • Author(s): Harada Noboru、Yoshizumi Tomoharu、Yoshiya Shohei、Takeishi Kazuki、Toshima Takeo、Itoh Shinji、Ikegami Toru、Fukuda Mio、Masuda Satohiro、Mori Masaki
  • Journal Title: Experimental and Clinical Transplantation Volume: 18 Issue: 4 Pages: 485-490
  • DOI: 10.6002/ect.2020.0041
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• [Journal Article] Association of lenvatinib plasma concentration with clinical efficacy and adverse events in patients with hepatocellular carcinoma (2020)
  • Author(s): Hata Kojiro、Suetsugu Kimitaka、Egashira Nobuaki、Makihara Yoko、Itoh Shinji、Yoshizumi Tomoharu、Tanaka Masatake、Kohjima Motoyuki、Watanabe Hiroyuki、Masuda Satohiro、Ieiri Ichiro
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 86 Issue: 6 Pages: 803-813
  • DOI: 10.1007/s00280-020-04178-x
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• [Journal Article] Influence of POR*28 Polymorphisms on CYP3A5*3-Associated Variations in Tacrolimus Blood Levels at an Early Stage after Liver Transplantation (2020)
  • Author(s): Nakamura Takahiro、Fukuda Mio、Matsukane Ryosuke、Suetsugu Kimitaka、Harada Noboru、Yoshizumi Tomoharu、Egashira Nobuaki、Mori Masaki、Masuda Satohiro
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 7 Pages: 2287-2287
  • DOI: 10.3390/ijms21072287
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of four commercial immunoassays used in measuring the concentration of tacrolimus in blood, and their cross-reactivity to its metabolites (2020)
  • Author(s): Shigematsu Tomohiro、Suetsugu Kimitaka、Yamamoto Nanae、Tsuchiya Yuichi、Masuda Satohiro
  • Journal Title: Therapeutic Drug Monitoring Volume: in press Issue: 3 Pages: 1-10
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• [Journal Article] Significance of ethnic factors in immunosuppressive therapy management after organ transplantation. (2020)
  • Author(s): Yamada T, Zhang M, Masuda S
  • Journal Title: Ther Drug Monit. Volume: Feb 20 Issue: 3 Pages: 369-380
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• [Journal Article] CγP3A5 genotype as a potential pharmacodynamic biomarker for tacrolimus therapy in ulcerative colitis in Japanese patients. (2020)
  • Author(s): Yamamoto Y, Nakase H, Matsuura M, Maruyama S, Masuda S.
  • Journal Title: Int J Mol Sci. Volume: 21 Issue: 12 Pages: 4347-4347
  • DOI: 10.3390/ijms21124347
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Donor CYP3A5 Gene Polymorphism Alone Cannot Predict Tacrolimus Intrarenal Concentration in Renal Transplant Recipients (2020)
  • Author(s): Zhang Mengyu、Tajima Soichiro、Shigematsu Tomohiro、Fu Rao、Noguchi Hiroshi、Kaku Keizo、Tsuchimoto Akihiro、Okabe Yasuhiro、Egashira Nobuaki、Masuda Satohiro
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 8 Pages: 2976-2976
  • DOI: 10.3390/ijms21082976
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Pharmacology Research for Promoting Individualized Cancer Chemotherapy (2019)
  • Author(s): Watanabe Hiroyuki、Uchida Mayako、Masuda Satohiro
  • Journal Title: YAKUGAKU ZASSHI Volume: 139 Issue: 6 Pages: 901-909
  • DOI: 10.1248/yakushi.18-00213-1
  • NAID: 130007657111
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2019-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Pharmaceutical Formulation on the Mucosal Concentration of 5-Aminosalicylic Acid and <i>N</i>-Acetylmesalamine in Japanese Patients with Ulcerative Colitis (2019)
  • Author(s): Yamamoto Y, Masuda S, Nakase H, Matsuura M, Maruyama S, Hisamatsu T, Suzuki Y, Matsubara K.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Issue: 1 Pages: 81-86
  • DOI: 10.1248/bpb.b18-00561
  • NAID: 130007542208
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  • Year and Date: 2019-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Recent topics on the mechanisms of immunosuppressive therapy-related neurotoxicities (2019)
  • Author(s): Zhang W, Egashira N, Masuda S
  • Journal Title: Int J Mol Sci Volume: 20 Issue: 13 Pages: 13-13
  • DOI: 10.3390/ijms20133210
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• [Journal Article] Safety and efficacy of PD-1 inhibitors in non?small cell lung cancer patients positive for antinuclear antibodies (2019)
  • Author(s): Yoneshima Yasuto、Tanaka Kentaro、Shiraishi Yoshimasa、Hata Kojiro、Watanabe Hiroyuki、Harada Taishi、Otsubo Kohei、Iwama Eiji、Inoue Hiroyuki、Masuda Satohiro、Nakanishi Yoichi、Okamoto Isamu
  • Journal Title: Lung Cancer Volume: 130 Pages: 5-9
  • DOI: 10.1016/j.lungcan.2019.01.014
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• [Journal Article] Usefulness of medication instruction sheets for sharing information on cancer chemotherapy within the health care team (2019)
  • Author(s): Uchida M, Nakamura T, Watanabe H, Kato K, Miyamoto T, Akashi K & Masuda S
  • Journal Title: Pharmazie Volume: 74 Pages: 566-569
  • Peer Reviewed
• [Journal Article] Simultaneous determination of plasma concentration of 12 oral molecular-targeted drugs by ultra-performance liquid chromatography-tandem mass spectrometry (2019)
  • Author(s): Yuichi TSUCHIYA, Kimitaka SUETSUGU, Nanae YAMAMOTO, Daisuke KOBAYASHI, Toshikazu TSUJI, Hiroyuki WATANABE, Nobuaki EGASHIRA, Satohiro MASUDA
  • Journal Title: The Japanese Journal of Therapeutic Drug Monitoring Volume: 36 Pages: 105-116
  • Peer Reviewed
• [Journal Article] Clinical prospects of biomarkers for the early detection and/or prediction of organ injury associated with pharmacotherapy (2019)
  • Author(s): Tajima Soichiro、Yamamoto Nanae、Masuda Satohiro
  • Journal Title: Biochemical Pharmacology Volume: 170 Pages: 113664-113664
  • DOI: 10.1016/j.bcp.2019.113664
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Urinary Human Epididymis Secretory Protein 4 as a Useful Biomarker for Subclinical Acute Rejection Three Months after Kidney Transplantation (2019)
  • Author(s): Tajima Soichiro、Fu Rao、Shigematsu Tomohiro、Noguchi Hiroshi、Kaku Keizo、Tsuchimoto Akihiro、Okabe Yasuhiro、Masuda Satohiro
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 19 Pages: 4699-4699
  • DOI: 10.3390/ijms20194699
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of CYP3A5, POR, and CYP2C19 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation (2019)
  • Author(s): Suetsugu Kimitaka、Mori Yasuo、Yamamoto Nanae、Shigematsu Tomohiro、Miyamoto Toshihiro、Egashira Nobuaki、Akashi Koichi、Masuda Satohiro
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 10 Pages: 2413-2413
  • DOI: 10.3390/ijms20102413
  • Peer Reviewed / Open Access
• [Journal Article] Pirfenidone alleviates lung ischemia-reperfusion injury in a rat model (2019)
  • Author(s): Saito Masao、Chen-Yoshikawa Toyofumi F.、Suetsugu Kimitaka、Okabe Ryo、Takahagi Akihiro、Masuda Satohiro、Date Hiroshi
  • Journal Title: The Journal of Thoracic and Cardiovascular Surgery Volume: 158 Issue: 1 Pages: 289-296
  • DOI: 10.1016/j.jtcvs.2018.08.098
  • Peer Reviewed
• [Journal Article] Neutrophil Gelatinase-Associated Lipocalin Is Not Associated with Tacrolimus-Induced Acute Kidney Injury in Liver Transplant Patients Who Received Mycophenolate Mofetil with Delayed Introduction of Tacrolimus (2019)
  • Author(s): Fukuda Mio、Suetsugu Kimitaka、Tajima Soichiro、Katsube Yurie、Watanabe Hiroyuki、Harada Noboru、Yoshizumi Tomoharu、Egashira Nobuaki、Mori Masaki、Masuda Satohiro
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 12 Pages: 3103-3103
  • DOI: 10.3390/ijms20123103
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy (2019)
  • Author(s): Brunet M, van Gelder T, Asberg A, Haufroid V, Hesselink DA, Langman L, Lemaitre F, Marquet P, Seger C, Shipkova M, Vinks A, Wallemacq P, Wieland E, Masuda S, Christians U & Bergan S
  • Journal Title: Therapeutic Drug Monitoring Volume: 41 Issue: 3 Pages: 261-307
  • DOI: 10.1097/ftd.0000000000000640
  • Peer Reviewed
• [Journal Article] Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation (2018)
  • Author(s): Fu Rao、Tajima Soichiro、Suetsugu Kimitaka、Watanabe Hiroyuki、Egashira Nobuaki、Masuda Satohiro
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• [Journal Article] Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats (2018)
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• [Journal Article] Prophylactic Effect of Dexamethasone on Regorafenib-Related Fatigue and/or Malaise: A Randomized, Placebo-Controlled, Double-Blind Clinical Study in Patients with Unresectable Metastatic Colorectal Cancer (KSCC1402/HGCSG1402). (2018)
  • Author(s): Tanioka H, Miyamoto Y, Tsuji A, Asayama M, Shiraishi T, Yuki S, Kotaka M, Makiyama A, Shimokawa M, Shimose T, Masuda S, Yamaguchi T, Komatsu Y, Saeki H, Emi Y, Baba H, Oki E, Maehara Y; Kyushu Study Group of Clinical Cancer (KSCC).
  • Journal Title: Oncology. Volume: 94(5) Issue: 5 Pages: 289-296
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  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetics and Pharmacodynamics of Once-Daily Tacrolimus Compared With Twice-Daily Tacrolimus in the Early Stage After Living Donor Liver Transplantation. (2018)
  • Author(s): Iwasaki M, Yano I, Fukatsu S, Hashi S, Yamamoto Y, Sugimoto M, Fukudo M, Masuda S, Nakagawa S, Yonezawa A, Kaido T, Uemoto S, Matsubara K.
  • Journal Title: Ther Drug Monit Volume: 40 Issue: 6 Pages: 675-681
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  • NAID: 120006559313
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• [Journal Article] EGFR T790M変異陽性の非小細胞肺がんに対するオシメルチニブの副作用解析 実臨床と臨床試験における副作用の比較検討 (2018)
  • Author(s): 田川 慎二, 梶原 亮佑, 末次 王卓, 辻 敏和, 渡邊 裕之 & 増田 智先
  • Journal Title: 医療薬学 Volume: 44 Pages: 355-362
  • NAID: 130007677090
  • Peer Reviewed
• [Journal Article] 炎症性腸疾患治療におけるDDS 現在と未来 (2018)
  • Author(s): 増田 智先 & 山本 由貴
  • Journal Title: Drug Delivery System Volume: 33 Pages: 397-4065
  • NAID: 130007603851
  • Peer Reviewed
• [Journal Article] 院外処方せんに表示した臨床検査値に関する疑義照会内容の解析 (2018)
  • Author(s): 佐野 梓, 末次 王卓, 秦 晃二郎, 柊迫 美咲, 片山 美幸, 田中 瑠美, 田島 壮一郎, グリム 理恵子, 辻 敏和, 渡邊 裕之, 金谷 朗子 & 増田 智先
  • Journal Title: 医療薬学 Volume: 44 Pages: 229-235
  • NAID: 130007644343
  • Peer Reviewed
• [Journal Article] 関節リウマチ患者における服薬支援の開始タイミングの特定 Health Assessment Questionnaireに基づいた支援需要の解析 (2018)
  • Author(s): 佐々木 恵一, 辻 敏和, 柳原 有希, 近森 綾子, 渡邊 裕之, 橋本 昌文, 木本 泰孝, 堀内 孝彦 & 増田 智先
  • Journal Title: 医療薬学 Volume: 44 Pages: 261-269
  • NAID: 130007661854
  • Peer Reviewed
• [Presentation] 免疫抑制薬血中濃度測定の全国QCサーベイ2021の報告 (2022)
  • Author(s): 増田智先
  • Organizer: 第55回 日本臨床腎移植学会
  • Invited
• [Presentation] 免疫抑制薬血中濃度測定の全国QCサーベイ2020の報告 (2021)
  • Author(s): 増田智先
  • Organizer: 第54回 日本臨床腎移植学会
  • Invited
• [Presentation] 肝移植後の免疫抑制療法の進歩 (2021)
  • Author(s): 増田智先
  • Organizer: 第37回日本TDM学会学術大会
  • Invited
• [Presentation] 検査値の活用について：熱中症の季節のポイント (2021)
  • Author(s): 増田智先
  • Organizer: 令和３年度伊丹市薬剤師会研修会
  • Invited
• [Presentation] 免疫抑制薬血中濃度測定の全国QCサーベイの報告2021 (2021)
  • Author(s): 増田智先
  • Organizer: 第５７回日本移植学会総会
  • Invited
• [Presentation] 免疫抑制役の血中濃度測定法と精度管理 (2020)
  • Author(s): 増田智先
  • Organizer: Liver Transplant Postoperative Management Forum 2019
  • Invited
• [Presentation] 免疫抑制薬血中濃度の全国QCサーベイ2019の報告 (2020)
  • Author(s): 増田智先
  • Organizer: 第53回 日本臨床腎移植学会
  • Invited
• [Presentation] タクロリムス投与経路変更時の用量調節におけるCYP3A5遺伝子多型情報の有用性 (2020)
  • Author(s): 末次王卓、 森 康雄、 山本奈々絵、 重松智博、 宮本敏浩、 赤司浩一、増田智先、江頭伸昭
  • Organizer: 第42回日本造血細胞移植学会総会
• [Presentation] 免疫抑制薬血中濃度測定の全国QCサーベイの報告：2020 (2020)
  • Author(s): 増田智先
  • Organizer: 第56回 日本移植学会総会
  • Invited
• [Presentation] 肺がん患者のがん薬物療法における腎障害を反映する尿中バイオマーカーの探索 (2020)
  • Author(s): 田島壮一郎、渡邊裕之、福田未音、田川慎二、佐田裕子、槇原洋子、秦晃二郎、辻敏和、岡本勇、増田智先、江頭伸昭
  • Organizer: 第30回日本医療薬学会年会
  • Invited
• [Presentation] 腎移植患者におけるタクロリムスの移植腎組織濃度に及ぼすCYP3A5遺伝子多型の影響 (2020)
  • Author(s): 重松智博、田島壮一郎、張夢雨、末次王卓、岡部安博、増田智先、江頭伸昭、家入一郎
  • Organizer: 第30回日本医療薬学会年会
• [Presentation] TDM-QCを通じた外部精度管理の実際と展望 (2020)
  • Author(s): 増田智先
  • Organizer: 第60回日本臨床化学会年次学術集会
  • Invited
• [Presentation] 肝移植後のタクロリムス体内動態に及ぼすCYP3A5*3・POR*28多型の影響 (2020)
  • Author(s): 福田未音、中村昂洋 、松金良祐、末次王卓、原田昇、吉住朋晴、江頭伸昭、森 正樹、家入一郎、増田智先
  • Organizer: 第41回日本臨床薬理学会学術総会
• [Presentation] タクロリムス単剤投与による腎障害モデルラットの作成とその評価 (2020)
  • Author(s): 付 饒、田島 壮一郎、重松 智博、張 夢雨、江頭 伸昭、家入 一郎、増田 智先
  • Organizer: 第41回日本臨床薬理学会学術総会
• [Presentation] 腎移植患者における移植腎組織中タクロリムス濃度に対するドナー腎CYP3A5遺伝子多型の影響に関する検討 (2020)
  • Author(s): 張 夢雨、田島 壮一郎、重松 智博、付 饒、岡部 安博、江頭 伸昭、家入 一郎、増田 智先
  • Organizer: 第41回日本臨床薬理学会学術総会
• [Presentation] 造血幹細胞移植後のタクロリムス投与経路変更時の個別化投与設計に向けた遺伝子多型情報の有用性評価 (2020)
  • Author(s): 末次王卓、 森 康雄、 山本奈々絵、 重松智博、 宮本敏浩、 江頭伸昭、赤司浩一、増田智先、家入 一郎
  • Organizer: 第41回日本臨床薬理学会学術総会
• [Presentation] 免疫抑制薬のTDM標準化GLの2学会協働による策定 (2019)
  • Author(s): 増田智先
  • Organizer: 第52回日本臨床腎移植学会
  • Invited
• [Presentation] 新しいイメージング技術を用いた抗体医薬の腫瘍内局所薬物動態の解析 (2019)
  • Author(s): 松金 良祐、林 光博、高橋 優、濱田 哲暢、増田 智先
  • Organizer: 日本薬学会第139年会
  • Invited
• [Presentation] がん薬物療法における慎重投与例:薬学的介入 (2019)
  • Author(s): 増田智先、南 晴奈、池田宗彦、渡邊裕之
  • Organizer: JSMO2019 / 第17回日本臨床腫瘍学会学術集会
  • Invited
• [Presentation] 腸管、腎尿細管の薬物代謝と膜輸送における機能連携 (2019)
  • Author(s): 増田智先
  • Organizer: 第50回日本消化器吸収学会
  • Invited
• [Presentation] 免疫抑制薬血中濃度測定の全国QCサーベイの報告：2019 (2019)
  • Author(s): 増田智先
  • Organizer: 第55回日本移植学会総会
  • Invited
• [Presentation] 肝臓移植領域におけるエベロリムスのTDM (2019)
  • Author(s): 増田智先、福田未音、重松智博、勝部友理絵、山本奈々絵、末次王卓、田島壮一郎、渡邊裕之、江頭伸昭
  • Organizer: 第55回日本移植学会総会
  • Invited
• [Presentation] TDM精度管理全国サーベイ：免疫抑制薬 (2019)
  • Author(s): 増田智先
  • Organizer: 第29回日本医療薬学会年会
  • Invited
• [Presentation] A consensus guideline on TDM of immuno-suppressive drugs used in organ transplantation (2019)
  • Author(s): Satohiro Masuda
  • Organizer: Asia Pacific Transplant CAUCUS 2019
  • Int'l Joint Research / Invited
• [Presentation] Urinary Microtubule-Associated Protein Light Chain3 and Neutrophil Gelatinase-Associated Lipocalin, as Potential Noninvasive Biomarkers for Subclinical Rejection at 3 Months after Kidney Transplantation (2019)
  • Author(s): Soichiro Tajima, Rao Fu, Mio Fukuda, Kimitaka Suetsugu, Yasuhiro Okabe, and Satohiro Masuda
  • Organizer: the 2019 American Transplant Congress (ATC)
  • Int'l Joint Research
• [Presentation] Physiological and pathophysiological interplay between OCT2/SLC22A2 and MATE/SLC47A transporters in the kidney (2019)
  • Author(s): Satohiro Masuda, Ryosuke Matsukane, Yurie Katsube, Soichiro Tajima, Hiroyuki Watanabe
  • Organizer: BioMedical Transporters 2019
  • Int'l Joint Research / Invited
• [Presentation] Role of MATE1 in the platinum-based chemotherapy against endometrial cancer (2019)
  • Author(s): Ryosuke Matsukane, Hiroyuki Watanabe, Satohiro Masuda
  • Organizer: BioMedical Transporters 2019
  • Int'l Joint Research
• [Presentation] Development and evaluation of an automated robotic system for preparing antineoplastic drugs (2019)
  • Author(s): Hiroyuki Watanabe, Toshihiro Irisa, Toshikazu Tsuji, Nobuaki Egashira, Satohiro Masuda
  • Organizer: 2019 ASHP Midyear Clinical Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] 新しいイメージング技術を用いた抗体医薬の腫瘍内局所薬物動態の解析 (2019)
  • Author(s): 松金 良祐, 林 光博, 高橋 優, 濱田 哲暢, 増田 智先
  • Organizer: 日本薬学会第139年会
  • Invited
• [Presentation] 免疫抑制薬TDMQCワークショップ報告 (2019)
  • Author(s): 増田智先
  • Organizer: 第52回 日本臨床腎移植学会
  • Invited
• [Presentation] Urinary Biomarkers Reflecting Drug-induced Nephrotoxicity (2018)
  • Author(s): Satohiro Masuda
  • Organizer: 2nd World Congress on Pharmacology & Toxicology
  • Int'l Joint Research / Invited
• [Presentation] Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia in rats (2018)
  • Author(s): Nobuaki Egashira, Shota Yamamoto, Satohiro Masuda
  • Organizer: 18th World congress of basic and clinical pharmacology (WCP2018)
  • Int'l Joint Research
• [Presentation] Novel high-sensitive drug detecting, PID method reveals intra-tumor pharma-cokinetics of trastuzumab and factors affect to its remarkable heterogeneity (2018)
  • Author(s): Ryosuke Matsukane, Mitsuhiro Hayashi, Masaru Takahashi, Mayu Ouchi, Hiroaki Aikawa, Hisatake Okada, Satohiro Masuda, Akinobu Hamada
  • Organizer: 18th World congress of basic and clinical pharmacology (WCP2018)
  • Int'l Joint Research
• [Presentation] Role of mTOR inhibitors in solid organ transplantation (2018)
  • Author(s): Satohiro Masuda
  • Organizer: 18th World congress of basic and clinical pharmacology (WCP2018)
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of Urinary Biomarkers for Acute Kidney Injury in Patients Receiving Lung Cancer Chemotherapy (2018)
  • Author(s): Hiroyuki Watanabe, Mio Fukuda, Satohiro Masuda
  • Organizer: STP (Society of Toxicologic Pathology) 37th Annual Symposium
  • Int'l Joint Research
• [Presentation] Relationship between teicoplanin-induced toxicity and blood concentrations in neonates and children (2018)
  • Author(s): Takaaki Yamada , Satohiro Masuda
  • Organizer: STP (Society of Toxicologic Pathology) 37th Annual Symposium
  • Int'l Joint Research
• [Presentation] 薬物動態学的研究を薬剤師がどう臨床に活かすか：医師・臨床薬理学研究者との連携事例 (2018)
  • Author(s): 山田孝明、福田剛史、増田智先
  • Organizer: 第45回日本小児臨床薬理学会学術集会
  • Invited
• [Presentation] 免疫抑制薬TDM標準化ガイドラインVer.2策定とQC全国サーベイの報告 (2018)
  • Author(s): 増田智先
  • Organizer: 第54回日本移植学会総会
  • Invited
• [Presentation] 免疫抑制薬の測定法：多様性を理解するために (2018)
  • Author(s): 増田智先
  • Organizer: 第35回日本TDM学会・学術大会
  • Invited
• [Presentation] 臓器移植患者における免疫抑制薬の適正使用：腎移植領域 (2018)
  • Author(s): 増田智先
  • Organizer: 第2回 京都桂腎移植セミナー
  • Invited
• [Book] ここからはじめる検査値×処方箋の読み方 第2版 (2019)
  • Author(s): 増田 智先、渡邊 裕之、金谷 朗子
  • Total Pages: 416
  • Publisher: じほう
  • ISBN: 4840752168