Analysis of retinal circuit development and function
| Project/Area Number |
18H02593
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 48010:Anatomy-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 網膜 / 神経回路 / 視細胞 / シナプス / ノックアウトマウス / 脳・神経 / 発生分化 / 神経科学 / 遺伝子 / 発生・分化 / マウス / 神経活動 |
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| Outline of Final Research Achievements |
We have studied molecular mechanisms underlying retinal photoreceptor development, synapse format ion, and retinal degeneration. In the current study, we identified candidate genes involved in retina circuit formation and analyzed their possible functions in the retina. We generated knockout and double-knockout mice and performed electrophysiological analysis and histological analysis. We carried out analyses on the Samd7 and Samd11 double knockout mice. We found that these molecules are essential for the regulation of light sensitivity and normal synaptic transmission from photoreceptor cells to bipolar cells. We reported these results as a research journal paper.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、中枢神経系における神経回路形成と機能発現のメカニズムの理解の進歩に貢献するとともに、網膜変性症を含む失明にいたる網膜疾患の視覚再生研究の基盤となると期待される。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] The Genetic Basis of Morphological Diversity in Domesticated Goldfish2020
Author(s)
Kon Tetsuo、Omori Yoshihiro、Fukuta Kentaro、Wada Hironori、Watanabe Masakatsu、Chen Zelin、Iwasaki Miki、Mishina Tappei、Matsuzaki Shin-ichiro S.、Yoshihara Daiki、Arakawa Jumpei、Kawakami Koichi、Toyoda Atsushi、Burgess Shawn M.、Noguchi Hideki、Furukawa Takahisa
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Journal Title
Current Biology
Volume: 30
Issue: 12
Pages: 2260-2274.e6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] GRP30-expressing gastric chief cells do not differentiate but are eliminated via PDK-dependent cell competition during development of metaplasia.2020
Author(s)
1.Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K.
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Journal Title
Gastroenterology
Volume: 158
Issue: 6
Pages: 1650-1666
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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