| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
We have studied molecular mechanisms underlying retinal photoreceptor development, synapse format ion, and retinal degeneration. In the current study, we identified candidate genes involved in retina circuit formation and analyzed their possible functions in the retina. We generated knockout and double-knockout mice and performed electrophysiological analysis and histological analysis. We carried out analyses on the Samd7 and Samd11 double knockout mice. We found that these molecules are essential for the regulation of light sensitivity and normal synaptic transmission from photoreceptor cells to bipolar cells. We reported these results as a research journal paper.
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