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Study on TRIC and MG23 channels

Research Project

Project/Area Number 18H02597
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 48020:Physiology-related
Research InstitutionKyoto University

Principal Investigator

Takeshima Hiroshi  京都大学, 薬学研究科, 教授 (70212024)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords小胞体 / Ca2+ストア / Ca2+シグナリング / Ca2+シグナル / カウンターイオン / TRICチャネル / MG23チャネル / Ca2+放出 / イオンチャネル / カルシウムストア
Outline of Final Research Achievements

In our analyzing TRIC and MG23 proteins in intracellular Ca2+ stores, we detected several new findings including major issues as described below. 1) TRIC-A-mediated activation of ryanodine receptors is essential for normal cardiac functions, and this activation is likely caused by direct protein-protein interaction between them. 2) In contrast to TRIC-A, TRIC-B frequently shows cooperative gating, and the unique may contribute to the support of IP3 receptor-mediated Ca2+ release. 3) We found spontaneous Ca2+ entry mediated by TRP family channel members in growth plate chondrocytes and peritoneal macrophages.

Academic Significance and Societal Importance of the Research Achievements

細胞内Ca2+シグナルは多様な機能を制御するため、その分子機序の解を目指す本研究のは学術的意義は高い。また、本研究により明らかになったCa2+シグナルを構築する分子機序は、新たな創薬標的を提供し、医薬領域への波及効果を有する。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (11 results)

All 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (1 results) (of which Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] オハイオ州大(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Oxford大(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Ohio州立大/Wisconsin大(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages2021

    • Author(s)
      Liu Feng、Xu Luxin、Nishi Miyuki、Ichimura Atsuhiko、Takeshima Hiroshi
    • Journal Title

      Cell Calcium

      Volume: 96 Pages: 102381-102381

    • DOI

      10.1016/j.ceca.2021.102381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle2020

    • Author(s)
      Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama T, Zou X, Takeshima H, Zhou J, Ma J.
    • Journal Title

      Circulation Reserach

      Volume: 126 Issue: 4 Pages: 417-435

    • DOI

      10.1161/circresaha.119.316241

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decreased cardiac pacemaking and attenuated b-adrenergic response in TRIC-A knockout mice.2020

    • Author(s)
      Murakami, M., Toyama, Y., Yonekura, M., Ohba, T., Matsuzaki, Y., Sawamura, D., Murakami, A. M., Nishi, M., Itagaki, S., Tomita, H. & Takeshima, H. 15, 2020. Doi:
    • Journal Title

      PLOS One

      Volume: 15 Issue: 6 Pages: e0230465-e0230465

    • DOI

      10.1371/journal.pone.0230465

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced activity of multiple TRIC-B channels; an ER/SR mechanism to boost counterion currents.2019

    • Author(s)
      O'Brien F, Eberhardt D, Witschas K, El-Ajouz S, Iida T, Nishi M, Takeshima H, Sitsapesan R, Venturi E.
    • Journal Title

      J Physiol.

      Volume: 印刷中 Issue: 10 Pages: 2691-2705

    • DOI

      10.1113/jp277241

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.2019

    • Author(s)
      Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H.
    • Journal Title

      Science signaling

      Volume: 12 Issue: 576 Pages: 4847-4847

    • DOI

      10.1126/scisignal.aaw4847

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 心臓におけるTRIC-Aの機能2021

    • Author(s)
      竹島浩
    • Organizer
      日本生理学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      https://www.pharm.kyoto-u.ac.jp/biochem/

    • Related Report
      2020 Annual Research Report
  • [Remarks] http://www.pharm.kyoto-u.ac.jp/biochem/

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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