| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
In our analyzing TRIC and MG23 proteins in intracellular Ca2+ stores, we detected several new findings including major issues as described below. 1) TRIC-A-mediated activation of ryanodine receptors is essential for normal cardiac functions, and this activation is likely caused by direct protein-protein interaction between them. 2) In contrast to TRIC-A, TRIC-B frequently shows cooperative gating, and the unique may contribute to the support of IP3 receptor-mediated Ca2+ release. 3) We found spontaneous Ca2+ entry mediated by TRP family channel members in growth plate chondrocytes and peritoneal macrophages.
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