Functional development of circadian regulation system
Project/Area Number |
18H02600
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 48020:Physiology-related
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Yagita Kazuhiro 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90324920)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | 概日リズム / 体内時計 / 発生学 / 細胞分化 / 母子同調 / 機能発生学 / 体節形成 / 分節時計 / 発生 |
Outline of Final Research Achievements |
Previously, we found that ES cells and early embryo cells do not display discernible circadian oscillation, whereas circadian clock oscillation appears after in vitro differentiation culture. Moreover, we have revealed that the circadian clocks are re-disappeared when differentiated cells are reprogrammed to regain pluripotency, indicating that the emergence of circadian clock is programmed tightly linked with cellular differentiation. We showed that the development of the mammalian circadian clock requires two steps. The first is an epigenetic and transcriptional program-mediated cellular differentiation process (cell-lineage determination process), and the second is the establishment of the circadian feedback loops, in which the post-transcriptional regulation of Clock functions as a rate-modulating mechanism. These sequential mechanisms may explain, at least in part, the late emergence of mammalian circadian clock oscillation in the developmental process (Umemura et al, PNAS, 2017).
|
Academic Significance and Societal Importance of the Research Achievements |
現在、都市機能の24時間化(24時間社会)のみならず、急速なIoT化や超少子高齢化(2025年問題)など、社会構造の大きな変化に直面している。本研究開発課題である概日リズム障害による複合的脳病態は、単に交替制勤務者の健康問題のみならず、トラックやバス等の事故、病院・警察・消防などの社会インフラ維持などとも関連する。これらの諸課題は近未来の社会が直面するリアルな問題である。本研究課題では、日常生活に起因する健康課題として非常に社会的な要請が高まっている概日リズム障害の病態解明に必須である、概日リズムの成立原理とそのメカニズムの解明を進めた。
|
Report
(4 results)
Research Products
(34 results)
-
-
-
-
-
-
[Journal Article] Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice2020
Author(s)
Inokawa Hitoshi, Umemura Yasuhiro, Shimba Akihiro, Kawakami Eiryo, Koike Nobuya, Tsuchiya Yoshiki, Ohashi Munehiro, Minami Yoichi, Cui Guangwei, Asahi Takuma, Ono Ryutaro, Sasawaki Yuh, Konishi Eiichi, Yoo Seung-Hee, Chen Zheng, Teramukai Satoshi, Ikuta Koichi, Yagita Kazuhiro
-
Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 2569-2569
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Enhanced metastatic growth after local tumor resection in the presence of synchronous metastasis in a mouse allograft model of neuroblastoma2019
Author(s)
Inoue M, Tsuchiya Y, Koike N, Umemura Y, Inokawa H, Togashi Y, Maniwa J, Higashi M, Fumino S, Tajiri T, Yagita K
-
Journal Title
Pediatric Surgery International
Volume: 35
Issue: 12
Pages: 1403-1411
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.2019
Author(s)
Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
-
Journal Title
Science Advance
Volume: 23
Issue: 1
Pages: 9060-9060
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Journal Article] Identification of circadian clock modulators from existing drugs2018
Author(s)
T. Katherine Tamai, Yusuke Nakane, Wataru Ota, Akane Kobayashi, Masateru Ishiguro, Naoya Kadofusa, Keisuke Ikegami, Kazuhiro Yagita, Yasufumi Shigeyoshi, Masaki Sudo, Taeko Nishiwaki-Ohkawa, Ayato Sato, & Takashi Yoshimura
-
Journal Title
EMBO Molecular Medicine
Volume: -
Issue: 5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-