| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
In this study, we focused on the function of LRRK1 in (1) EGFR intracellular trafficking and (2) mitophagy, a selective autophagy to remove damaged mitochondria. Regarding (1), we found that LRRK1 and the phosphatase PTEN regulate EGFR intracellular trafficking by phosphorylating and dephosphorylating small G protein Rab7, respectively. Regarding (2), LRRK1 is phosphorylated and activated by ULK1, which phosphorylates Rab7 on damaged mitochondria and recruits ATG9, an important factor for the formation of isolation membrane. We also found that LRRK1 may competitively regulate mitophagy with LRRK2.
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