| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Biological membranes are composed of asymmetrically distributed phospholipid bilayers. For example, phosphatidylserine (PS) and phosphatidylethanolamine in cell membranes are localized in its inner leaflet. This asymmetric distribution of phospholipids is established and maintained by a dynamic equilibrium state of translocations of phospholipids across the lipid bilayers or between organelles. However, the mechanisms by which cells control this equilibrium of phospholipids and maintain the asymmetry of biological membranes are largely unknown. In this study, we elucidated the molecular mechanisms of the asymmetric distribution of PS, mainly regulated by phospholipid flippases.
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