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Pathogenesis of NRF2-addicted cancers

Research Project

Project/Area Number 18H02621
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 49010:Pathological biochemistry-related
Research InstitutionTohoku University

Principal Investigator

Motohashi Hozumi  東北大学, 加齢医学研究所, 教授 (00282351)

Co-Investigator(Kenkyū-buntansha) 赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
KeywordsNRF2 / がん / 悪性化 / 硫黄 / 酸化酵素 / Nrf2 / 硫黄代謝 / NRF2活性化がん / ミトコンドリア / イオウ代謝
Outline of Final Research Achievements

NRF2 is a master transcriptional regulator of cytoprotective genes. While NRF2 activation is principally beneficial for our health, NRF2 activation in cancer cells drives cancer malignancy and causes poor prognosis of cancer patients. We explored new therapeutic targets for NRF2-activated cancers. We found that unique enhancer formation underlies the unique transcriptional activation by NRF2 in KEAP1-mutant NSCLC cells. Among the NRF2-dependent enhancers unique to NRF2-activated cancers, NOTCH3 enhancer was found to make a key contribution to the tumor-initiating activity. Histopathological analysis supported clinical relevance of NRF2-NOTCH3 axis in lung adenocarcinoma. Because NRF2 strongly increases detoxification and extrusion capacities of chemotherapeutic drugs, NOTCH3, a transmembrane protein that can be accessed from outside of cells, is expected to be a favorable therapeutic target for KEAP1-mutant NSCLCs.

Academic Significance and Societal Importance of the Research Achievements

NRF2活性化がんでは、細胞膜上の薬剤を排泄するトランスポーターの発現が増加しており、抗がん剤を速やかに排泄してしまうことが難治性の原因の一つである。NOTCH3は膜タンパク質であり、細胞外からの機能阻害が可能であることから、NOTCH3を狙った治療戦略はNRF2活性化肺がんで増加している薬剤排泄トランスポーターの影響を回避できると考えられる。NRF2活性化がんは、がんの遺伝子変異の解析から診断可能であることから、本研究成果は、がんの遺伝子診断に基づいたオーダーメイドがん治療として有効であることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (155 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (38 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 32 results,  Open Access: 23 results) Presentation (106 results) (of which Int'l Joint Research: 24 results,  Invited: 36 results) Book (4 results) Remarks (4 results)

  • [Int'l Joint Research] New York University(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Southampton University(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Thales Papagiannakopoulos/New York University(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response2021

    • Author(s)
      Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 16-16

    • DOI

      10.1038/s41467-020-20185-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species2021

    • Author(s)
      Kasamatsu Shingo、Ida Tomoaki、Koga Taisei、Asada Kosho、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: in press Issue: 18 Pages: 1407-1419

    • DOI

      10.1089/ars.2020.8073

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The pivotal role of sulfide catabolism in hypoxia tolerance2021

    • Author(s)
      Marutani E, Morita M, Hirai S, Kai S, Grange RMH, Miyazaki Y, Nagashima F, Trager L, Magliocca A, Ida T, Matsunaga T, Flicker DR, Corman BHP, Mori N, Yamazaki Y, Batten A, Li R, Tanaka T, Ikwda T, Nakagawa A, Atochin DN, Ihara H, Olenchock BA, Shen X, Nishida M, Hanaoka K, Kevil CG, Xian M, Bloch DB, Akaike T, et al.
    • Journal Title

      Nature Communications

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Skeletanl muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice2021

    • Author(s)
      Onoki T, Izumi Y, Takahashi M, Murakami S, Matsumaru D, Ohta N, Wati SM, Hatanaka N, Katsuoka F, Okutsu M, Yabe Y, Hagiwara Y, Kanzaki M, Bamba T, Itoi E, Motohashi H
    • Journal Title

      Redox Biol

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer2021

    • Author(s)
      Sekine Hiroki、Motohashi Hozumi
    • Journal Title

      Cancers

      Volume: 13 Issue: 3 Pages: 541-541

    • DOI

      10.3390/cancers13030541

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands2020

    • Author(s)
      Wati Sisca Meida、Matsumaru Daisuke、Motohashi Hozumi
    • Journal Title

      Redox Biology

      Volume: 36 Pages: 101603-101603

    • DOI

      10.1016/j.redox.2020.101603

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors2020

    • Author(s)
      Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, Hiroshi Kitamura, Hozumi Motohashi, Masayuki Yamamoto
    • Journal Title

      Cancer Research

      Volume: 0 Issue: 16 Pages: 00-00

    • DOI

      10.1158/0008-5472.can-19-2888

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 contributes to the weight gain of mice during space travel2020

    • Author(s)
      Suzuki, T., et al., Koshiba, S. et al., Yamamoto, M.(合計37名、本研究者は18番目)
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 496-496

    • DOI

      10.1038/s42003-020-01227-2

    • NAID

      120007161347

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers2020

    • Author(s)
      Okazaki Keito、Anzawa Hayato、Liu Zun、Ota Nao、Kitamura Hiroshi、Onodera Yoshiaki、Alam Md. Morshedul、Matsumaru Daisuke、et al.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 5911-5911

    • DOI

      10.1038/s41467-020-19593-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss2020

    • Author(s)
      Oishi Tetsuya、Matsumaru Daisuke、Ota Nao、Kitamura Hiroshi、Zhang Tianxiang、Honkura Yohei、Katori Yukio、Motohashi Hozumi
    • Journal Title

      npj Aging and Mechanisms of Disease

      Volume: 6 Issue: 1 Pages: 14-14

    • DOI

      10.1038/s41514-020-00053-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] がん細胞の代謝を標的とする治療戦略の可能性2020

    • Author(s)
      岡崎慶斗、本橋ほづみ
    • Journal Title

      実験医学 増刊号

      Volume: 38 Pages: 2469-2475

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides2020

    • Author(s)
      Sawa Tomohiro、Motohashi Hozumi、Ihara Hideshi、Akaike Takaaki
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 9 Pages: 1245-1245

    • DOI

      10.3390/biom10091245

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] がんの代謝研究から:新たな創薬標的の可能性2020

    • Author(s)
      岸野明洋、村上昌平、赤池孝章、本橋ほづみ
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 51 Pages: 576-584

    • NAID

      40022417704

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impacts of NRF2 activation in non–small-cell lung cancer cell lines on extracellular metabolites2020

    • Author(s)
      Saigusa Daisuke、Motoike Ikuko N.、Saito Sakae、Zorzi Michael、Aoki Yuichi、Kitamura Hiroshi、Suzuki Mikiko、Katsuoka Fumiki、Ishii Hirofumi、Kinoshita Kengo、Motohashi Hozumi、Yamamoto Masayuki
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 2 Pages: 667

    • DOI

      10.1111/cas.14278

    • URL

      https://pure.teikyo.jp/en/publications/eb6de64e-f99d-4c99-af50-300bf428c50a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] From germ cells to neonates: the beginning of life and the KEAP1-NRF2 system.2020

    • Author(s)
      Matsumaru D, Motohashi H.
    • Journal Title

      J Biochem.

      Volume: 167 Pages: 133-138

    • DOI

      10.1093/jb/mvz070

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KEAP1-NRF2系制御による健康長寿2020

    • Author(s)
      松丸大輔、本橋ほづみ
    • Journal Title

      糖尿病・内分泌代謝科

      Volume: 50 Pages: 190-196

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Metabolic features of cancer cells in NRF2 addiction status2020

    • Author(s)
      Okazaki K, Papagiannakopoulos T, Motohashi H
    • Journal Title

      Biophysical Reviews

      Volume: in press Issue: 2 Pages: 435-441

    • DOI

      10.1007/s12551-020-00659-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.2019

    • Author(s)
      Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.
    • Journal Title

      Redox Biol

      Volume: 21 Pages: 101096-101096

    • DOI

      10.1016/j.redox.2019.101096

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response2019

    • Author(s)
      Nagashima Ryuichi、Kosai Hitomi、Masuo Masahiro、Izumiyama Keiko、Noshikawaji Taketo、Morimoto Motoko、Kumaki Satoru、Miyazaki Yasunari、Motohashi Hozumi、Yamamoto Masayuki、Tanaka Nobuyuki
    • Journal Title

      The Journal of Immunology

      Volume: 202 Issue: 5 Pages: 1331-1339

    • DOI

      10.4049/jimmunol.1801180

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoR12019

    • Author(s)
      Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 41467-41467

    • DOI

      10.1038/s41467-019-08829-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells2019

    • Author(s)
      Nishimura Akira、Nasuno Ryo、Yoshikawa Yuki、Jung Minkyung、Ida Tomoaki、Matsunaga Tetsuro、Morita Masanobu、Takagi Hiroshi、Motohashi Hozumi、Akaike Takaaki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 37 Pages: 13781-13788

    • DOI

      10.1074/jbc.ra119.009203

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 活性イオウによる生体防御とエネルギー代謝2019

    • Author(s)
      西村明、本橋ほづみ、赤池孝章
    • Journal Title

      月刊 細胞

      Volume: 51 Pages: 4-7

    • Related Report
      2019 Annual Research Report
  • [Journal Article] KEAP1-NRF2制御系による代謝制御と炎症応答2019

    • Author(s)
      安藤正勝、本橋ほづみ
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 72 Pages: 7-13

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Sulfur-utilizing cytoprotection and energy metabolism2019

    • Author(s)
      Motohashi Hozumi、Akaike Takaaki
    • Journal Title

      Current Opinion in Physiology

      Volume: 9 Pages: 1-8

    • DOI

      10.1016/j.cophys.2019.03.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KEAP1-NRF2制御系によるストレス応答とイオウ代謝2019

    • Author(s)
      本橋ほづみ
    • Journal Title

      実験医学

      Volume: 37 Pages: 1999-2004

    • Related Report
      2019 Annual Research Report
  • [Journal Article] がん細胞の代謝とCNC転写因子MRF1, NRF22019

    • Author(s)
      関根弘樹、本橋ほづみ
    • Journal Title

      医学のあゆみ

      Volume: 270 Pages: 429-435

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells.2019

    • Author(s)
      Fujii S, Sawa T, Motohashi H, Akaike T.
    • Journal Title

      Br J Pharmacol

      Volume: 176 Issue: 4 Pages: 607-615

    • DOI

      10.1111/bph.14356

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nucleomethylin deficiency impairs embryonic erythropoiesis2018

    • Author(s)
      Murakami Shohei、Suzuki Takuma、Yokoyama Wataru、Yagi Satoko、Matsumura Keita、Nakajima Yuka、Harigae Hideo、Fukamizu Akiyoshi、Motohashi Hozumi
    • Journal Title

      J. Biochem.

      Volume: 印刷中 Issue: 5 Pages: 413-423

    • DOI

      10.1093/jb/mvx086

    • NAID

      40021555326

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo.2018

    • Author(s)
      Yoshida E, Suzuki T, Morita M, Taguchi K, Tsuchida K, Motohashi H, Doita M, and Yamamoto M
    • Journal Title

      Genes to Cells

      Volume: - Issue: 5 Pages: 386-392

    • DOI

      10.1111/gtc.12579

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018

    • Author(s)
      Sekine Hiroki、Okazaki Keito、Kato Koichiro、Alam M. Morshedul、Shima Hiroki、Katsuoka Fumiki、Tsujita Tadayuki、Suzuki Norio、Kobayashi Akira、Igarashi Kazuhiko、Yamamoto Masayuki、Motohashi Hozumi
    • Journal Title

      Molecular and Cellular Biology

      Volume: 38 Issue: 17 Pages: 00252-18

    • DOI

      10.1128/mcb.00252-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding2018

    • Author(s)
      Kanamoto Mayu、Tsuchiya Yoshihiro、Nakao Yuki、Suzuki Takafumi、Motohashi Hozumi、Yamamoto Masayuki、Kamata Hideaki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0203978-e0203978

    • DOI

      10.1371/journal.pone.0203978

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A2018

    • Author(s)
      Dodo Mina、Kitamura Hiroshi、Shima Hiroki、Saigusa Daisuke、Wati Sisca Meida、Ota Nao、Katsuoka Fumiki、Chiba Hatsune、Okae Hiroaki、Arima Takahiro、Igarashi Kazuhiko、Koseki Takeyoshi、Sekine Hiroki、Motohashi Hozumi
    • Journal Title

      The Journal of Biochemistry

      Volume: 165 Issue: 4 Pages: 323

    • DOI

      10.1093/jb/mvy108

    • NAID

      40021893390

    • URL

      https://pure.teikyo.jp/en/publications/3ce041b9-b7fc-4f79-8894-395bc617553f

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NRF2 addiction in cancer cells2018

    • Author(s)
      Kitamura H and Motohashi H
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 4 Pages: 900-911

    • DOI

      10.1111/cas.13537

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis2018

    • Author(s)
      Yamamoto Masayuki、Kensler Thomas W.、Motohashi Hozumi
    • Journal Title

      Physiological Reviews

      Volume: 98 Issue: 3 Pages: 1169-1203

    • DOI

      10.1152/physrev.00023.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] レドックス疾患学:レドックス制御の破綻による病態と新たな疾患概念2018

    • Author(s)
      本橋ほづみ、赤池孝章、内田浩二、末松誠
    • Journal Title

      実験医学

      Volume: 36 Pages: 642-648

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NRF2依存性難治がんの成立機構とその特性2018

    • Author(s)
      北村大志、本橋ほづみ
    • Journal Title

      実験医学

      Volume: 36 Pages: 809-814

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Tumors sweeten macrophages with acids2018

    • Author(s)
      Sekine Hiroki、Yamamoto Masayuki、Motohashi Hozumi
    • Journal Title

      Nature Immunology

      Volume: 19 Issue: 12 Pages: 1281-1283

    • DOI

      10.1038/s41590-018-0258-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レドックス制御を担う転写制御機構と抗老化作用2018

    • Author(s)
      大野木孝嘉、本橋ほづみ
    • Journal Title

      化学工業

      Volume: 69 Pages: 817-823

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress2021

    • Author(s)
      Kitamura H, Oishi T, Murakami S, Katori Y, Motohashi H
    • Organizer
      第155回東北大学加齢医学研究所 集談会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 酵母における活性硫黄分子による寿命制御2021

    • Author(s)
      Jung Minkyung、西村明、井田智章、守田匡伸、松永哲郎、高木博史、本橋ほづみ、赤池孝章
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Longevity is dependent on sulfide:quinone oxidoreductase mediated energy metabolism in fission yeast2021

    • Author(s)
      守田匡伸、西村明、井田智章、Jung Minkyung、松永哲郎、高田剛、本橋ほづみ、赤池孝章
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] NADPH oxidatses and NO synthetases function as sulfur oxidoreductases and activates super sulfur species conferring anti-microbial host defense2021

    • Author(s)
      高田剛、井田智章、松永哲郎、守田匡伸、土屋幸弘、渡邊泰男、住本英樹、本橋ほづみ、赤池孝章
    • Organizer
      第94回日本細菌学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ミトコンドリア機能と共役する超硫黄代謝2021

    • Author(s)
      岸野明洋、村上昌平、関根弘樹、赤池孝章、本橋ほづみ
    • Organizer
      第1回レドックスR&D戦略委員会シンポジウム サテライトシンポジウム「超硫黄分子が加速するレドックスバイオロジーのパラダイム・シフト」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Cytoprotective Function of NRF2 and its Role in Sulfur Metabolism2021

    • Author(s)
      Motohashi H
    • Organizer
      Symposium “Regulation of Redox Signalling by NRF2 in Health and Disease” SFRRI 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] KEAP1の抑制によるNRF2経路の活性化がもたらす加齢性難聴の予防効果の検討2020

    • Author(s)
      大石哲也、松丸大輔、北村大志、本蔵陽平、香取幸夫、本橋ほづみ
    • Organizer
      日本生化学会東北支部 第86回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of NRF2 activation on aging phenotypes of salivary glands2020

    • Author(s)
      Wati SM, Matsumaru D, Motohashi H
    • Organizer
      日本生化学会東北支部 第86回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress2020

    • Author(s)
      Kitamura H, Oishi T, KatoH T, Okunishi I, Motohashi H
    • Organizer
      AAIC20
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新型コロナウイルス呼気オミックス診断法の開発2020

    • Author(s)
      井田智章、高田剛、守田匡伸、松永哲郎、Jung Minkyung、澤智裕、杉浦久敏、本橋ほづみ、赤池孝章
    • Organizer
      第13回日本生体防御学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 活性硫黄分子による新型コロナウイルス感染症の予防・治療法の開発2020

    • Author(s)
      松永哲郎、井田智章、高田剛、Jung Minkyung、澤智裕、守田匡伸、本橋ほづみ、赤池孝章
    • Organizer
      第13回日本生体防御学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 活性硫黄分子によるインフルエンザウイルス肺炎の予防・治療法の開発2020

    • Author(s)
      守田匡伸、滝田克也、佐野寛仁、杉浦久敏、市川朋宏、沼倉忠久、井田智章、山田充啓、京極自彦、松永哲郎、本橋ほづみ、赤池孝章
    • Organizer
      第13回日本生体防御学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 感染防御における一酸化窒素合成酵素およびNADPHオキシダーゼによる新規活性硫黄代謝機構の解明2020

    • Author(s)
      高田剛、井田智章、松永哲郎、守田匡伸、土屋幸弘、渡邊泰男、住本英樹、本橋ほづみ、赤池孝章
    • Organizer
      第13回日本生体防御学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 硫黄を利用した生体防御機構とエネルギー代謝2020

    • Author(s)
      本橋ほづみ
    • Organizer
      第93回日本生化学会大会 シンポジウム「硫黄の化学的理解に立脚したカルコゲン・バイオロジー」
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cytoprotective and anti-aging function of NRF2 and its role in sulfur metabolism2020

    • Author(s)
      Kishino A, Murakami S, Sekine H, Motohashi H
    • Organizer
      Coldspring Harbor Meeting: Mechanisms of Aging
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NRF2活性化がんの悪性化をもたらすエンハンサー・リモデリング2020

    • Author(s)
      岡崎慶斗、本橋ほづみ
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 硫黄を利用した生体防御機構とエネルギー代謝2020

    • Author(s)
      岸野明洋、村上昌平、関根弘樹、本橋ほづみ
    • Organizer
      第73回日本酸化ストレス学会 第20回日本NO学会 合同学術集会 シンポジウム「Persulfide Biology and Medicine」
    • Related Report
      2020 Annual Research Report
  • [Presentation] KEAP1-MRF2制御系による抗老化作用と硫黄代謝2020

    • Author(s)
      本橋ほづみ
    • Organizer
      第5回日本心血管協会年次学術総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 硫黄を利用した生体防御機構とエネルギー代謝2020

    • Author(s)
      本橋ほづみ
    • Organizer
      第47回日本毒性学会学術年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] NRF2依存性がんの悪性化機構と治療戦略2020

    • Author(s)
      本橋ほづみ
    • Organizer
      千里ライフサイエンス新適塾「難病への挑戦」第43回会合
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] NADPH oxidaseによる活性硫黄代謝リモデリングと感染防御機構2020

    • Author(s)
      井田智章、松永哲郎、守田匡伸、高田剛、本橋ほづみ、住本英樹、赤池孝章
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Sulfide: quinone oxidoreductase-dependent energy metabolism in fission yeast.2020

    • Author(s)
      Abidin ZHQ, Nishimura A, Ida T, Morita M, Jung M, Matsunaga T, Motohashi H, Akaike T
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reactive CysSSH via cysteinyl-tRNA synthetase expression depending on energy metabolism in yeast.2020

    • Author(s)
      Yoon S, Nishimura A, Ida T, Jung M, Morita M, Matsunaga T, Takagi H, Motohashi H, Akaike T
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細菌のタンパク質翻訳共役型システインパースルフィド合成機構の解明2020

    • Author(s)
      松永哲郎、井田智章、西村明、ジョンミンキョン、守田匡伸、澤智裕、居原秀、本橋ほづみ、赤池孝章
    • Organizer
      第93回日本細菌学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 硫化水素キノン酸化還元酵素(SQR)による硫化水素の解毒機構と生理機能の解明2020

    • Author(s)
      松永哲郎、守田匡伸、西村明、井田智章、本橋ほづみ、赤池孝章
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] がんの代謝研究―新たな治療標的の可能性―2020

    • Author(s)
      本橋ほづみ
    • Organizer
      第53回ヒューマンサイエンス総合研究セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] NRF2活性化がんの悪性化機構と硫黄代謝2020

    • Author(s)
      本橋ほづみ
    • Organizer
      第1回日本癌学会若手の会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] NRF2依存性がんの悪性化におけるエピゲノム制御2020

    • Author(s)
      本橋ほづみ
    • Organizer
      エピジェネティック療法研究会 第12回講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 硫黄を利用した生体防御機構とエネルギー代謝2020

    • Author(s)
      本橋ほづみ
    • Organizer
      第19回分子予防環境医学研究会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Biosynthesis and physiological functions of reactive cysteine persulfiddes.2019

    • Author(s)
      Nishimura A, Ida T, Morita M, Matsunaga T, Takagi H, Motohashi H, Akaike T
    • Organizer
      The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Translation-coupled proteinpolysulfidation, discpvery of a novel cysteine persulfide synthase.2019

    • Author(s)
      Ida T, Morita M, Nishimura A, Matsunaga T, Ihara H, Sawa T, Motohashi H, Akaike T
    • Organizer
      The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a transgenic mouse line for monitoring exposure history to electrophilic stress.2019

    • Author(s)
      Oishi T, Kitamura H, Katori Y, Motohashi H
    • Organizer
      The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非小細胞性肺がんにおけるエンハンサーリモデリングによるNRF2-NOTCH3経路の活性化と幹細胞性への貢献2019

    • Author(s)
      岡崎慶斗、安澤隼人、北村大志、小野寺好明、Md. Morshedul Alam、松丸大輔、太田奈緒、桜田晃、岡田克典、勝岡史城、山本雅之、鈴木貴、木下賢吾、関根弘樹、本橋ほづみ
    • Organizer
      日本生化学会東北支部 第85回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸化ストレスに対するNRF2活性化履歴モニタリングマウスの作成2019

    • Author(s)
      大石哲也、北村大志、香取幸夫、本橋ほづみ
    • Organizer
      日本生化学会東北支部 第85回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Selenophosphate synthetase 1 stabilizes NRF2 and regulates its antioxidant response pathway.2019

    • Author(s)
      Alam MM, Sekine H, Motohashi H
    • Organizer
      日本生化学会東北支部 第85回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 硫化水素キノン酸化還元酵素(SQR)を介したミトコンドリアにおけるイオウ依存型エネルギー形成機構の解明2019

    • Author(s)
      大野木孝嘉、松永哲郎、守田匡伸、西村明、井田智章、赤池孝章、本橋ほづみ
    • Organizer
      第72回日本酸化ストレス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸化ストレスに対するNRF2活性化履歴モニタリングマウスの作成2019

    • Author(s)
      大石哲也、北村大志、香取幸夫、本橋ほづみ
    • Organizer
      第72回日本酸化ストレス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 種横断的な活性パースルフィド産生経路とその生理的意義の解明2019

    • Author(s)
      西村明、井田智章、守田匡伸、松永哲郎、高木博史、本橋ほづみ、赤池孝章
    • Organizer
      第72回日本酸化ストレス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ミトコンドリア・イオウ呼吸選択的硫化水素キノン酸化還元酵素(SQR)欠損マウスの開発と機能解析2019

    • Author(s)
      守田匡伸、井田智章、田中智弘、松永哲郎、西村明、西田基宏、本橋ほづみ、赤池孝章
    • Organizer
      第72回日本酸化ストレス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] がん細胞におけるO-結合型糖鎖修飾によるプロテアソーム制御の分子機構2019

    • Author(s)
      関根弘樹、岡崎慶斗、Md. Morshedul Alam、本橋ほづみ
    • Organizer
      第7回がんと代謝研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The roles of Nrf2 in oxidative stress and neuroinflammation in App knock-in Alzheimer’s diseases model mice.2019

    • Author(s)
      Uruno A, Matsumaru D, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Motohashi H, Yamamoto M
    • Organizer
      The Environmental Response V
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establoshment of a transgenic mouse line for monitoring exposure history to electrophilic stress.2019

    • Author(s)
      Oishi T, Kitamura H, Katori Y, Motohashi H
    • Organizer
      The Environmental Response V
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancer remodeling at the NOTCH3 locus licenses NRF2 for the promotion of a stem-like phenotype in non-small cell lung cancers.2019

    • Author(s)
      Okazaki K, Anzawa H, Kitamura H, Onodera Y, Alam MM, Matsumaru D, Suzuki T, Katsuoka F, Ota N, Sakurada A, Okada Y, Yamamoto M, Suzuki T, Kinoshita K, Sekine H, Motohashi H
    • Organizer
      The Environmental Response V
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of NRF2 activation on aging phenotypes of salivary glands.2019

    • Author(s)
      Wati SM, Matsumaru D, Motohashi H
    • Organizer
      The Environmental Response V
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sulfur metabolism and its role in NRF2-addicted cancer cells.2019

    • Author(s)
      Motohashi H
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of NRF2 activation on aging phenotypes of salivary glands.2019

    • Author(s)
      Wati SM, Matsumaru D, Motohashi H
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Sulfur metabolism rewiring in NRF2-adidcted cancer cells.2019

    • Author(s)
      Motohashi H
    • Organizer
      第57回日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Enhancer remodeling at the NOTCH3 locus licenses NRF2 for the promotion of a stem-like phenotype in lung cancers.2019

    • Author(s)
      Okazaki K, Motohashi H
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NRF2依存性がんとその代謝特性2019

    • Author(s)
      本橋ほづみ
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 硫黄を利用した生体防御とエネルギー代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      加齢研交流セミナー
    • Related Report
      2019 Annual Research Report
  • [Presentation] 硫黄を利用した生体防御機構とエネルギー代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 個体老化におけるRBA修飾変動の網羅的解析2019

    • Author(s)
      二口亜希子、松丸大輔、井上俊洋、富澤一仁、本橋ほづみ、魏范研
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NRF2 addiction and its metabolic impact on tumorigenesis.2019

    • Author(s)
      Hozumi Motohashi
    • Organizer
      The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NRF2依存性がんとイオウ代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2制御系による酸化ストレス応答と硫黄代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      第1回鶴岡カンファランス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 加齢制御における酸化ストレス応答の役割2019

    • Author(s)
      本橋ほづみ
    • Organizer
      Aging Forum
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] イオウを利用した細胞保護作用とエネルギー代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      Research PlaNet 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] イオウを利用した細胞保護作用とエネルギー代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      がん研セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス応答と健康長寿と介護2019

    • Author(s)
      本橋ほづみ
    • Organizer
      第15回男女共同参画フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 硫黄を利用した生体防御とエネルギー代謝2019

    • Author(s)
      本橋ほづみ
    • Organizer
      2019年度文部科学省新学術領域研究 学術研究支援基盤形成「先端モデル動物支援プラットフォーム」若手支援技術講習会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] NRF2 addiction in cancer cells and their metabolic and epigenetic features.2019

    • Author(s)
      Hozumi Motohashi
    • Organizer
      The Environmental Response V/ 17th JBS Biofrontier Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ワサビスルフィニルによるNrf2経路の活性化と抗老化作用の検討2019

    • Author(s)
      本橋ほづみ
    • Organizer
      第4回ワサビフォーラム「本わさびでつくるアクティブ高齢化社会」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] In vivo proof o sulfide:quinone oxidoreductase (SQR) function directy contributing to sulfur respiration in mammals.2019

    • Author(s)
      Nishimura A, Morita M, Ida T, Tanaka T, Matsunaga T, Nishida M, Motohashi H, Akaike T
    • Organizer
      Gordon Research Conference, Nitric Oxide
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The primary and principal pathway for reactive sulfur biosynthesis in mammals.2019

    • Author(s)
      Akaike T, Nishimura A, Ida T, Morita M, Matsunaga T, Motohashi H, Tsutsui M
    • Organizer
      Gordon Research Conference, Nitric Oxide
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NRF2 addiction of cancer cells and its impact on cancer metabolism.2019

    • Author(s)
      Motohashi H
    • Organizer
      Special Lecture, King’s BHF Centre Seminar Series & Aging Research at King’s (ARK) jointly
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] NRF2 addiction in cancer cells and its impact on metabolism.2019

    • Author(s)
      Motohashi H
    • Organizer
      Plenary Session 4: Metabolism, 11th AACR-JCA Joint Conference; Breakthroughs in Cancer Research: Biology to Precision Medicine.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NRF2 addiction in cancer cells and its impact on sulfur metabolism.2019

    • Author(s)
      Motohashi H
    • Organizer
      Gordon Research Conference, Oxidative Stress and Disease.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 転写因子NRF2によるストレス応答と代謝制御2018

    • Author(s)
      本橋ほづみ
    • Organizer
      生理学研究所研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
    • Related Report
      2018 Annual Research Report
  • [Presentation] KEAP1-NRF2制御系の活性化はアルツハイマー病様病態を改善する2018

    • Author(s)
      松丸大輔,領家梨恵,齋藤律水,三枝大輔,川島隆太,山本雅之,宇留野晃,本橋ほづみ
    • Organizer
      生理学研究所研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性パースルフィドによるミトコンドリア膜電位形成機構の解明2018

    • Author(s)
      松永哲郎、守田匡伸、南嶋洋司、西村明、井田智章、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第71回日本酸化ストレス学会・日本NO学会合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミトコンドリア/イオウ呼吸選択的Sulfide-quinone reductase (SQR:硫化水素キノン還元酵素)欠損マウスの開発2018

    • Author(s)
      守田匡伸、井田智章、松永哲郎、西村明、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第71回日本酸化ストレス学会・日本NO学会合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] システイニルtRNA合成酵素によるパースルフィド合成制御機構の解明2018

    • Author(s)
      井田智章、西村明、守田匡伸、松永哲郎、澤智裕、居原秀、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第71回日本酸化ストレス学会・日本NO学会合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ニトロソグルタチオン代謝酵素アルコールデヒドロゲナーゼ5のタンパク質ポリスルフィド化による活性制御機構2018

    • Author(s)
      藤井重元、笠松真吾、Md. Morshedul Alam、井田智章、守田匡伸、居原秀、西村明、松永哲郎、本橋ほづみ、赤池孝章
    • Organizer
      第71回日本酸化ストレス学会・日本NO学会合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] NRF2による生体防御とがんの悪性化2018

    • Author(s)
      本橋ほづみ、井田智章、Md. Morshedul Alam、北村大志、赤池孝章
    • Organizer
      第71回日本酸化ストレス学会・日本NO学会合同学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] KEAP1-NRF2制御系の活性化はアルツハイマー病様病態を改善する2018

    • Author(s)
      松丸大輔、領家梨恵、斎藤律水、三枝大輔、川島隆太、山本雅之、宇留野晃、本橋ほづみ
    • Organizer
      日本生化学会東北支部第84回例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 種横断的新しいシステインパースルフィド合成酵素の発見2018

    • Author(s)
      井田智章、守田匡伸、西村明、松永哲郎、居原秀、澤智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第29回日本生体防御学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 親電子解毒代謝系システインパースルフィドの新しい合成酵素の発見2018

    • Author(s)
      井田智章、守田匡伸、西村明、松永哲郎、居原秀、澤智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 硫化水素解毒酵素sulfide-qionone oxidoreductaseの機能解析2018

    • Author(s)
      西村明、守田匡伸、南嶋洋司、井田智章、松永哲郎、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体防御機構KEAP1-NRF2制御系とイオウ呼吸2018

    • Author(s)
      本橋ほづみ、赤池孝章
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Biosynthesis mechanisms and physiological functions of reactive persulfides.2018

    • Author(s)
      Nishimura A, Ida T, Morita M, Fujii S, Takagi H, Motohashi H, Akaike T
    • Organizer
      10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Translation-coupled protein polysulfidation, a unique biosynthesis pathway of cysteine persulfide.2018

    • Author(s)
      Ida T, Nishimura A, Morita M, Ihara H, Sawa T, Fujii S, Motohashi H, Akaike T
    • Organizer
      10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KEAP1-NRF2制御系の活性化はアルツハイマー病様病態を改善する2018

    • Author(s)
      松丸大輔、領家梨恵、斎藤律水、三枝大輔、齊藤貴志、西道隆臣、川島隆太、山本雅之、宇留野晃、本橋ほづみ
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] システイニルtRNA合成酵素のパースルフィド合成制御機構2018

    • Author(s)
      井田智章、西村明、守田匡伸、松永哲郎、澤智裕、居原秀、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ミトコンドリア/イオウ呼吸選択的硫化水素キノン還元酵素(SQR)欠損マウスの開発および機能解析2018

    • Author(s)
      守田匡伸、井田智章、田中智弘、松永哲郎、西村明、藤井重元、西田基宏、本橋ほづみ、赤池孝章
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 活性イオウ分子種によるミトコンドリア膜電位形成機構の解明2018

    • Author(s)
      松永哲郎、守田匡伸、西村明、井田智章、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Biosynthesis pathway and physiological functions of reactive persulfides.2018

    • Author(s)
      Nishimura A, Ida T, Morita M, Matsunaga T, Takagi H, Motohashi H, Akaike T
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] システイニルtRNA合成酵素によるシステインパースルフィド合成活性の発見とミトコンドリアエネルギー代謝制御2018

    • Author(s)
      澤智裕、本橋ほづみ、赤池孝章
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electrophilic response and sulfur metabolism regulated by KEAP1-NRF2 system.2018

    • Author(s)
      Motohashi H, Ida T, Alam MM, Kitamura H, Akaike T
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] De novo enhancer formation at the NOTCH3 locus licenses NRF2 for the promotion of a stem-like phenotype in non-small cell lung cancers.2018

    • Author(s)
      Okazaki K, Sekine H, Motohashi H
    • Organizer
      第13回研究所ネットワーク国際シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondria-specific SQR deficiency in mice causes lethal impairment of sulfur respiration.2018

    • Author(s)
      Morita M, Ida T, Tanaka T, Matsunaga T, Nishimura A, Fujii S, Nishida M, Motohashi H, Akaike T.
    • Organizer
      SFRBM 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 転写因子NRF2が制御する生体防御とがんの悪性化2018

    • Author(s)
      本橋ほづみ
    • Organizer
      第41回日本分子生物学会年会 がんと免疫細胞の代謝競合
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中枢神経系のレドックス・バランス制御による個体老化抑制の試み2018

    • Author(s)
      本橋ほづみ
    • Organizer
      AMED老化メカニズムの解明・制御プロジェクト 第2回リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] NRF2によるストレス応答機構と代謝制御2018

    • Author(s)
      本橋ほづみ
    • Organizer
      エクスポソームの生物学的理解とその医療応用(熊本大学薬学部)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] NRF2による代謝リプログラミングとがんの悪性化2018

    • Author(s)
      本橋ほづみ
    • Organizer
      第18回日本抗加齢医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Bright and dark sides of KEAP1-NRF2 system in carcinogenesis.2018

    • Author(s)
      Motohashi H
    • Organizer
      SFRRI 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NRF2 addiction in cancer cells and its impact on metabolism.2018

    • Author(s)
      Motohashi H
    • Organizer
      The 45th Naito Conference“Immunological and molecular bases for cancer immunotherapy”
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がんの成立と悪性化における生体防御機構KEAP1-NRF2制御系の役割2018

    • Author(s)
      本橋ほづみ
    • Organizer
      ホルモンと癌研究会2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model.2018

    • Author(s)
      Motohashi H
    • Organizer
      WCP2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 転写因子NRF2による生体防御とイオウ代謝2018

    • Author(s)
      本橋ほづみ
    • Organizer
      第72回日本細菌学会東北支部総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] NRF2-dependent transcriptional regulation unique to NRF2-addicted cancers.2018

    • Author(s)
      Motohashi H
    • Organizer
      Special seminar, Cochin, Paris
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] NRF2 addiction in cancer cells and its impact on metabolism.2018

    • Author(s)
      Motohashi H
    • Organizer
      The Korean Socety for Molecular and Cellular Biology (KSMCS) International Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NRF2-dependent transcriptional regulation unique to NRF2-addicted cancers.2018

    • Author(s)
      Motohashi H
    • Organizer
      CUK seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] NRF2依存性がんの代謝制御とその特徴2018

    • Author(s)
      本橋ほづみ
    • Organizer
      第38回日本分子腫瘍マーカー研究会 シンポジウム「分子腫瘍マーカー開発と臨床応用」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2制御系の活性化がもたらすアルツハイマー病海鮮効果2018

    • Author(s)
      本橋ほづみ
    • Organizer
      第37回日本認知症学会学術集会 ホットトピック徹底討論「老化研究を通して認知症克服への道を模索する」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] NRF2依存性がんの成立と悪性化機構2018

    • Author(s)
      本橋ほづみ
    • Organizer
      第57回日本薬学会東北支部大会 特別講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Environmental stress response mechanism for healthy aging2018

    • Author(s)
      Motohashi H
    • Organizer
      Winter School-Cuba 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 新臨床腫瘍学 改訂第6版 (がんと代謝)2021

    • Author(s)
      本橋ほづみ
    • Publisher
      南江堂
    • Related Report
      2020 Annual Research Report
  • [Book] シンプル生化学 (第21章 細胞増殖とがんの生化学 がんと代謝)2021

    • Author(s)
      本橋ほづみ
    • Publisher
      南江堂
    • Related Report
      2020 Annual Research Report
  • [Book] 進化するがん創薬2019

    • Author(s)
      清宮 啓之
    • Total Pages
      344
    • Publisher
      化学同人
    • ISBN
      4759817336
    • Related Report
      2019 Annual Research Report
  • [Book] 新臨床腫瘍学(改訂第5版)2018

    • Author(s)
      日本臨床腫瘍学会
    • Total Pages
      872
    • Publisher
      南江堂
    • ISBN
      9784524237883
    • Related Report
      2018 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所 遺伝子発現制御分野

    • URL

      https://www2.idac.tohoku.ac.jp/dep/ger/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 遺伝子発現制御分野

    • URL

      https://www.med.tohoku.ac.jp/about/laboratory/111.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所 遺伝子発現制御分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/ger/index.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所 遺伝子発現制御分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/ger/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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