| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Although type I interferon (IFN-I) is known to have the dual role of exacerbation and suppression of autoimmune diseases, its underlying molecular mechanism remain unclear. In this study, we addressed the issue by examining the B cell response to IFN-I. We showed that human B cells give rise to IL-10-producing plasmablasts by stimulating IFN-I, and revealed its properties. Furthermore, we found that the IL-10 plasmablasts inhibit T cell proliferation. We also showed that murine B cells respond to TLR agonists and IFN-I synergistically and cooperately to differentiate into IL-10-producing and non-producing plasmablasts.
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