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Molecular pathology of autoreactive inflammatory T cells

Research Project

Project/Area Number 18H02629
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionHokkaido University

Principal Investigator

Tomaru Utano  北海道大学, 医学研究院, 准教授 (20360901)

Co-Investigator(Kenkyū-buntansha) 辻 隆裕  北海道大学, 医学研究院, 客員研究員 (50462776)
石津 明洋  北海道大学, 保健科学研究院, 教授 (60321957)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords自己免疫 / 自己抗原 / プロテアソーム / メモリーT細胞 / 老化 / 慢性炎症 / 自己免疫疾患 / バイオマーカー / 自己応答性T細胞 / 細胞傷害性T細胞 / 診断マーカー
Outline of Final Research Achievements

The immune system is an important biological defense system for protecting the body from pathogens, but abnormal autoreactive immune responses develop autoimmune diseases and inflammatory diseases. In this study, to develop a useful biomarker for autoreactive inflammatory cells and pathological evaluation of autoimmune disease, we established gene-modified mouse model expressing ubiquitous self-antigens (USAs-Tg). Using this model, we found that autoreactive CD8+ cells showed memory phenotype with PD-1+ Lag-3+ Tim-3+ CTLA-4-. In addition, the activation state of antigen-presenting cells affects the differentiation of inflammation-inducing cells.

Academic Significance and Societal Importance of the Research Achievements

自己免疫疾患の病理診断としては、組織学的に特徴的な糸球体腎炎や血管炎等を除いては、リンパ球浸潤の程度やCD4/CD8分画、標的細胞の破壊像の検索が行われるものの、自己応答性・炎症惹起性免疫細胞の浸潤の程度を評価できる段階には至っていない。がんに限らず、自己免疫疾患のprecision medicine、医療向上を考える上で、より新しい治療体系の基礎となる病態解明、診断マーカーの検索が望まれている。本研究により自己免疫惹起性T細胞の特徴が明らかになり、自己免疫疾患の診断・治療展開を目指した基礎的知見が得られた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (58 results)

All 2021 2020 2019 2018 Other

All Journal Article (28 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 28 results,  Open Access: 11 results) Presentation (28 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Anti‐phosphatidylserine/prothrombin complex antibodies in patients with cutaneous vasculitis: Possible involvement in the pathogenesis2021

    • Author(s)
      Kawakami Tamihiro、Tamura Yuto、Dong Yupeng、Yoshinari Miku、Nishibata Yuka、Masuda Sakiko、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      The Journal of Dermatology

      Volume: 48 Issue: 5 Pages: 703-706

    • DOI

      10.1111/1346-8138.15810

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNase in the saliva can affect the detection of severe acute respiratory syndrome coronavirus 2 by real-time one-step polymerase chain reaction using saliva samples2021

    • Author(s)
      Nishibata Yuka、Koshimoto Shota、Ogaki Kenta、Ishikawa Erika、Wada Kosuke、Yoshinari Miku、Tamura Yuto、Uozumi Ryo、Masuda Sakiko、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Pathology - Research and Practice

      Volume: 220 Pages: 153381-153381

    • DOI

      10.1016/j.prp.2021.153381

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of radio-insensitive SMARCA4-deficient thoracic undifferentiated carcinoma with severe right heart failure2021

    • Author(s)
      Ito Shotaro、Asahina Hajime、Yamaguchi Naoko、Tomaru Utano、Hasegawa Tadashi、Hatanaka Yutaka、Hatanaka Kanako C.、Taguchi Hiroshi、Harada Taisuke、Ohira Hiroshi、Ikeda Daisuke、Mizugaki Hidenori、Kikuchi Eiki、Kikuchi Junko、Sakakibara-Konishi Jun、Shinagawa Naofumi、Konno Satoshi
    • Journal Title

      Respiratory Medicine Case Reports

      Volume: 32 Pages: 101364-101364

    • DOI

      10.1016/j.rmcr.2021.101364

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil fixation protocols suitable for substrates to detect anti-neutrophil cytoplasmic antibodies by indirect immunofluorescence2021

    • Author(s)
      Nishibata Yuka、Matsuzawa Shun、Satomura Yosuke、Ohtsuka Takeshi、Kuhara Motoki、Masuda Sakiko、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Pathology - Research and Practice

      Volume: 228 Pages: 153661-153661

    • DOI

      10.1016/j.prp.2021.153661

    • NAID

      120007171671

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis2021

    • Author(s)
      Takeuchi Sora、Kawakami Tamihiro、Okano Tatsuro、Shida Haruki、Nakazawa Daigo、Tomaru Utano、Ishizu Akihiro、Kadono Takafumi
    • Journal Title

      Pathobiology

      Volume: 89 Issue: 1 Pages: 23-28

    • DOI

      10.1159/000519869

    • NAID

      120007173221

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment2021

    • Author(s)
      Tomaru Utano、Ito Tomoki、Ohmura Yu、Higashikawa Kei、Miyajima Syota、Tomatsu Ruka、Higashi Tsunehito、Ishizu Akihiro、Kuge Yuji、Yoshioka Mitsuhiro、Kasahara Masanori
    • Journal Title

      The American Journal of Pathology

      Volume: 191 Issue: 1 Pages: 144-156

    • DOI

      10.1016/j.ajpath.2020.10.004

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas2020

    • Author(s)
      Kiuchi Takayuki、Tomaru Utano、Ishizu Akihiro、Imagawa Makoto、Iwasaki Sari、Suzuki Akira、Otsuka Noriyuki、Ohhara Yoshihito、Kinoshita Ichiro、Matsuno Yoshihiro、Dosaka-Akita Hirotoshi、Kasahara Masanori
    • Journal Title

      Journal of Clinical Pathology

      Volume: 74 Issue: 5 Pages: 300-306

    • DOI

      10.1136/jclinpath-2020-206618

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Neutrophil Extracellular Traps with the Development of Idiopathic Osteonecrosis of the Femoral Head2020

    • Author(s)
      Nonokawa Mayu、Shimizu Tomohiro、Yoshinari Miku、Hashimoto Yamato、Nakamura Yusuke、Takahashi Daisuke、Asano Tsuyoshi、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tanaka Satoshi、Tomaru Utano、Iwasaki Norimasa、Ishizu Akihiro
    • Journal Title

      The American Journal of Pathology

      Volume: 190 Issue: 11 Pages: 2282-2289

    • DOI

      10.1016/j.ajpath.2020.07.008

    • NAID

      120007168180

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of cathepsins B, D and K in thymic epithelial tumours2020

    • Author(s)
      Yamaguchi Naoko、Tomaru Utano、Kiuchi Takayuki、Ishizu Akihiro、Deguchi Takahiro、Otsuka Noriyuki、Tanaka Satoshi、Marukawa Katsuji、Matsuno Yoshihiro、Kitagawa Masanobu、Kasahara Masanori
    • Journal Title

      Journal of Clinical Pathology

      Volume: 74 Issue: 2 Pages: 84-90

    • DOI

      10.1136/jclinpath-2020-206551

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 122020

    • Author(s)
      Tanimura Shun、Nishida Mutsumi、Horie Tatsunori、Kamishima Tamotsu、Matsumoto Hitomi、Morimura Yutaka、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tomaru Utano、Atsumi Tatsuya、Ishizu Akihiro
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 115 Pages: 104454-104454

    • DOI

      10.1016/j.yexmp.2020.104454

    • NAID

      120007126051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between lysosomal-associated membrane protein-2 and anti-phosphatidylserine/prothrombin complex antibody in the pathogenesis of cutaneous vasculitis2020

    • Author(s)
      Kawakami Tamihiro、Kikuchi Ayaka、Miyabe Chie、Ikeda Takaharu、Takeuchi Sora、 Tamura Yuto、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Clinical and Experimental Rheumatology

      Volume: 124 Pages: 161-165

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A histopathological report of a 16-year-old male with peripheral pulmonary artery stenosis and Moyamoya disease with a homozygous RNF213 mutation2020

    • Author(s)
      Takahashi Kei、Nakamura Junichi、Sakiyama Shinya、Nakaya Toshitaka、Sato Takahiro、Watanabe Taku、Ohira Hiroshi、Makita Keishi、Tomaru Utano、Ishizu Akihiro、Tsujino Ichizo
    • Journal Title

      Respiratory Medicine Case Reports

      Volume: 29 Pages: 100977-100977

    • DOI

      10.1016/j.rmcr.2019.100977

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant thrombomodulin ameliorates autoimmune vasculitis via immune response regulation and tissue injury protection2020

    • Author(s)
      Watanabe-Kusunoki Kanako、Nakazawa Daigo、Kusunoki Yoshihiro、Kudo Takashi、Hattanda Fumihiko、Nishio Saori、Masuda Sakiko、Tomaru Utano、Kondo Takeshi、Atsumi Tatsuya、Ishizu Akihiro
    • Journal Title

      Journal of Autoimmunity

      Volume: 108 Pages: 102390-102390

    • DOI

      10.1016/j.jaut.2019.102390

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation and Disordered Degradation of Neutrophil Extracellular Traps in Necrotizing Lesions of Anti-Neutrophil Cytoplasmic Antibody?Associated Vasculitis2019

    • Author(s)
      Masuda Sakiko、Nonokawa Mayu、Futamata Emika、Nishibata Yuka、Iwasaki Sari、Tsuji Takahiro、Hatanaka Yutaka、Nakazawa Daigo、Tanaka Satoshi、Tomaru Utano、Kawakami Tamihiro、Atsumi Tatsuya、Ishizu Akihiro
    • Journal Title

      The American Journal of Pathology

      Volume: 189 Issue: 4 Pages: 839-846

    • DOI

      10.1016/j.ajpath.2019.01.007

    • NAID

      120006820166

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epitope recognized by anti-glomerular basement membrane (GBM) antibody in a patient with repeated relapse of anti-GBM disease2019

    • Author(s)
      Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tanaka Satoshi、Tomaru Utano、Nergui Mandkhai、Jia Xiaoyu、Cui Zhao、Zhao Ming-hui、Nakabayashi Kimimasa、Ishizu Akihiro
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 107 Pages: 165-170

    • DOI

      10.1016/j.yexmp.2019.02.005

    • NAID

      120006841052

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The presence of anti-neutrophil extracellular trap antibody in patients with microscopic polyangiitis.2019

    • Author(s)
      Hattanda F, Nakazawa D, Watanabe-Kusunoki K, Kusunoki Y, Shida H, Masuda S, Nishio S, Tomaru U, Atsumi T, Ishizu A.
    • Journal Title

      Rheumatology (Oxford)

      Volume: Mar 20 Issue: 7 Pages: 1293-1298

    • DOI

      10.1093/rheumatology/kez089

    • NAID

      120006864485

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmaceutical immunoglobulins reduce neutrophil extracellular trap formation and ameliorate the development of MPO-ANCA-associated vasculitis2019

    • Author(s)
      Uozumi Ryo、Iguchi Risa、Masuda Sakiko、Nishibata Yuka、Nakazawa Daigo、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Modern Rheumatology

      Volume: 1 Issue: 3 Pages: 1-7

    • DOI

      10.1080/14397595.2019.1602292

    • NAID

      120006844531

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Increased Vascular Signal in Arthritis-Prone Rats Without Joint Swelling Using Superb Microvascular Imaging Ultrasonography2019

    • Author(s)
      Horie Tatsunori、Nishida Mutsumi、Tanimura Shun、Kamishima Tamotsu、Tamai Erika、Morimura Yutaka、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tomaru Utano、Atsumi Tatsuya、Ishizu Akihiro
    • Journal Title

      Ultrasound in Medicine & Biology

      Volume: 45 Issue: 8 Pages: 2086-2093

    • DOI

      10.1016/j.ultrasmedbio.2019.04.002

    • NAID

      120006882071

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Native myeloperoxidase is required to make the experimental vasculitis model2019

    • Author(s)
      Nonokawa Mayu、Suzuki Ku、Hayashi Hideyuki、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tanaka Satoshi、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Arthritis Research & Therapy

      Volume: 21 Issue: 1 Pages: 296-296

    • DOI

      10.1186/s13075-019-2084-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells2019

    • Author(s)
      Tomaru Utano、Konno Saori、Miyajima Syota、Kimoto Rikuto、Onodera Mari、Kiuchi Shizuka、Murata Shigeo、Ishizu Akihiro、Kasahara Masanori
    • Journal Title

      Cell Reports

      Volume: 26 Issue: 3 Pages: 639-651

    • DOI

      10.1016/j.celrep.2018.12.078

    • NAID

      120006595593

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Diagnostic and Clinical Utility of the Myeloperoxidase?DNA Complex as a Biomarker in Otitis Media With Antineutrophil Cytoplasmic Antibody-associated Vasculitis2019

    • Author(s)
      Morita Shinya、Nakamaru Yuji、Nakazawa Daigo、Suzuki Masanobu、Hoshino Kimiko、Fukuda Atsushi、Hattanda Fumihiko、Kusunoki Kanako、Tomaru Utano、Ishizu Akihiro、Homma Akihiro
    • Journal Title

      Otology & Neurotology

      Volume: 40 Issue: 2 Pages: e99-e106

    • DOI

      10.1097/mao.0000000000002081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis and therapeutic interventions for ANCA-associated vasculitis2018

    • Author(s)
      Nakazawa Daigo、Masuda Sakiko、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Nature Reviews Rheumatology

      Volume: 15 Issue: 2 Pages: 91-101

    • DOI

      10.1038/s41584-018-0145-y

    • NAID

      120006643590

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute fulminant myocarditis in a patient with primary Sjogren’s syndrome2018

    • Author(s)
      Watanabe T、Takahashi Y、Hirabayashi K、Tomaru U、Machida M
    • Journal Title

      Scandinavian Journal of Rheumatology

      Volume: 48 Issue: 2 Pages: 164-165

    • DOI

      10.1080/03009742.2018.1514068

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Autoreactive Type II NKT Cells: A Pilot Study of Comparison Between Healthy Individuals and Patients with Vasculitis2018

    • Author(s)
      Nishioka Yusuke、Sonoda Takaomi、Shida Haruki、Kusunoki Yoshihiro、Hattanda Fumihiko、Tanimura Shun、Uozumi Ryo、Yamada Mai、Nishibata Yuka、Masuda Sakiko、Nakazawa Daigo、Tomaru Utano、Atsumi Tatsuya、Ishizu Akihiro
    • Journal Title

      Cytometry Part A

      Volume: 93 Issue: 11 Pages: 1157-1164

    • DOI

      10.1002/cyto.a.23618

    • NAID

      120006769935

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological significance of PSF3 expression in uterine endometrial carcinomas2018

    • Author(s)
      Park Jong Kun、Otsuka Noriyuki、Tomaru Utano、Suzuki Hiroaki、Azuma Manabu、Okamoto Kazuhira、Yamashiro Katsushige、Kasahara Masanori
    • Journal Title

      Human Pathology

      Volume: 80 Pages: 104-112

    • DOI

      10.1016/j.humpath.2018.06.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated vasculitis: a case report2018

    • Author(s)
      Shida Haruki、Hashimoto Nobuhiro、Kusunoki Yoshihiro、Hattanda Fumihiko、Ogawa Yayoi、Hayashi Terumasa、Nakazawa Daigo、Masuda Sakiko、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      BMC Nephrology

      Volume: 19 Issue: 1 Pages: 145-145

    • DOI

      10.1186/s12882-018-0953-y

    • NAID

      120006484286

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides2018

    • Author(s)
      Nishioka Yusuke、Masuda Sakiko、Tomaru Utano、Ishizu Akihiro
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 548-548

    • DOI

      10.3389/fimmu.2018.00548

    • NAID

      120006414020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain-derived neurotrophic factor induces angiogenin secretion and nuclear translocation in human umbilical vein endothelial cells2018

    • Author(s)
      Mori Ayako、Nishioka Yusuke、Yamada Mai、Nishibata Yuka、Masuda Sakiko、Tomaru Utano、Honma Naoyuki、Moriyama Takanori、Ishizu Akihiro
    • Journal Title

      Pathology - Research and Practice

      Volume: 214 Issue: 4 Pages: 521-526

    • DOI

      10.1016/j.prp.2018.02.013

    • NAID

      120006626560

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] myosin light chain 6を認識する抗好中球細胞外トラップ(NETs)抗体はNETs分解阻害活性を持つ2021

    • Author(s)
      西端 友香, 益田 紗季子, 外丸 詩野, 石津 明洋
    • Organizer
      日本リウマチ学会総会・学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 本邦初POIKTMPの剖検例2021

    • Author(s)
      高橋 知一, 山口 直子, 大塚 紀幸, 佐藤 理子, 鈴木 雅, 田中 敏, 外丸 詩野, 笠原 正典
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 酸化ストレスの増大が自己免疫応答に与える影響について2021

    • Author(s)
      八尾 寅史, 外丸 詩野, 宮崎 佳代, 石津 明洋, 笠原 正典:
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ALK転座を伴うdisseminated juvenile xanthogranuloma(D-JXG)の一例2021

    • Author(s)
      若林 健人, 福井 秀章, 中里 信一, 高桑 恵美, 長 祐子, 本多 昌平, 外丸 詩野, 中澤 温子, 松野 吉宏
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] プロテアソーム機能低下が腎虚血再灌流障害時の酸化ストレス応答に与える影響について2021

    • Author(s)
      石井 保志, 外丸 詩野, 吉田 拓磨, 仲川 心平, 石津 明洋, 笠原 正典:
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] プロテアソーム機能低下は肥満で誘導される脂肪組織の炎症を増悪する2021

    • Author(s)
      仲川 心平, 外丸 詩野, 石津 明洋, 笠原 正典:
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 低酸素環境が好中球細胞外トラップ形成へ与える影響2021

    • Author(s)
      益田 紗季子, 西端 友香, 田中 敏, 外丸 詩野, 辻野 一三, 石津 明洋
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] プロテアソーム機能低下が褥瘡の病態形成に与える影響2021

    • Author(s)
      村田 恵理, 吉田 拓磨, 山本 彩晶, 石津 明洋, 外丸 詩野, 笠原 正典
    • Organizer
      日本病理学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗好中球細胞質抗体(ANCA)に続き抗糸球体基底膜(GBM)抗体が産生されるメカニズム2020

    • Author(s)
      西端 友香、益田 紗季子、中沢 大悟、外丸 詩野、石津 明洋
    • Organizer
      日本リウマチ学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 特発性大腿骨頭壊死症の発生における好中球細胞外トラップの関与2020

    • Author(s)
      清水 智弘、野々川 茉佑、西端 友香、益田 紗季子、高橋 大介、浅野 毅、田中 敏、外丸 詩野、岩崎 倫政、石津 明洋
    • Organizer
      日本整形外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] プロテアソーム機能低下が肥満による脂肪組織炎症に与える影響について2020

    • Author(s)
      仲川 心平、外丸 詩野、石津 明洋、笠原 正典
    • Organizer
      日本病理学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] プロテアソーム機能低下が腎虚血再灌流障害に与える影響について2020

    • Author(s)
      石井 保志、外丸 詩野、石津 明洋、笠原 正典
    • Organizer
      日本病理学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肺基礎疾患を有する肺炎患者における分解抵抗性好中球細胞外トラップの形成2020

    • Author(s)
      益田 紗季子、石橋 美郷、加藤 くるみ、西端 友香、田中 敏、外丸 詩野、辻野 一三、石津 明洋
    • Organizer
      日本病理学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胸腺上皮性腫瘍におけるカテプシンB、D、K発現2020

    • Author(s)
      山口 直子、外丸 詩野、木内 隆之、石津 明洋、松野 吉宏、北川 昌伸、笠原 正典
    • Organizer
      日本病理学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 血小板増多を示し、腫瘍内に髄外造血巣を伴ったAB型胸腺腫の一例.2019

    • Author(s)
      若林 健人, 福井 秀章, 高桑 恵美, 岡田 宏美, 新垣 雅人, 外丸 詩野, 三橋 智子, 松野 吉宏
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 末梢性T細胞リンパ腫関連血球貪食症候群による劇症肝炎の一例.2019

    • Author(s)
      村山 千咲, 松田 真奈, 大塚 紀幸, 山口 直子, 木内 隆之, 紺野 潤, 田中 敏, 外丸 詩野, 笠原 正典.
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロテアソーム阻害剤使用後の薬剤性心筋症の一剖検例.2019

    • Author(s)
      飯田 圭祐, 土橋 大樹, 木内 隆之, 大塚 紀幸, 石立 尚路, 辻 隆裕, 山口 圭介, 外丸 詩野, 深澤 雄一郎, 笠原 正典.
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] プロテアソーム機能低下が褥瘡の病態形成に与える影響.2019

    • Author(s)
      村田 恵理, 吉田 拓磨, 山本 彩晶, 牧田 啓史, 石津 明洋, 外丸 詩野, 笠原 正典.
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ANCA関連血管炎(AAV)の壊死性病変部における好中球細胞外トラップ(NETs)の存在と病的意義.2019

    • Author(s)
      益田 紗季子, 野々川 茉佑, 西端 友香, 岩崎 沙理, 辻 隆裕, 田中 敏, 外丸 詩野, 川上 民裕, 石津 明洋.
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗GBM抗体が認識するエピトープの表出に関する検討.2019

    • Author(s)
      西端 友香, 東 里緒, 益田 紗季子, 中沢 大悟, 田中 敏, 外丸 詩野, 石津 明洋.
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シクロフィリンDをターゲットとしたANCA関連壊死性血管炎に対する新規治療薬の開発.2019

    • Author(s)
      工藤 孝司, 中沢 大悟, 白鳥 里佳, 楠 加奈子, 西尾 妙織, 益田 紗季子, 外丸 詩野, 石津 明洋, 渥美 達也.
    • Organizer
      第47回日本臨床免疫学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞障害の制御とその破綻による病態発生 プロテアソームとストレス応答、病態関連性における役割.2018

    • Author(s)
      外丸 詩野
    • Organizer
      日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 皮膚虚血再灌流障害におけるNKG2Dシステムの役割についての検討.2018

    • Author(s)
      牧田 啓史、大塚 紀幸、外丸 詩野、村田 恵理、池下 隼司、笠原 正典.
    • Organizer
      日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮体部上皮性腫瘍におけるPSF3発現の臨床病理学的意義.2018

    • Author(s)
      朴 鐘建、大塚 紀幸、外丸 詩野、鈴木 宏明、山城 勝重、笠原 正典.
    • Organizer
      日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ANCA関連血管炎(AAV)の壊死性病変部における好中球細胞外トラップ(NETs)の存在と病的意義.ANCA関連血管炎(AAV)の壊死性病変部における好中球細胞外トラップ(NETs)の存在と病的意義.2018

    • Author(s)
      益田 紗季子、野々川 茉佑、西端 友香、岩崎 沙理、辻 隆裕、田中 敏、外丸 詩野、川上 民裕、石津 明洋.4.益田 紗季子、野々川 茉佑、西端 友香、岩崎 沙理、辻 隆裕、田中 敏、外丸 詩野、川上 民裕、石津 明洋.
    • Organizer
      日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] スタチンの関節炎抑制効果とその機序の解明.2018

    • Author(s)
      谷村 瞬、西田 睦、神島 保、西端 友香、益田 紗季子、中沢 大悟、外丸 詩野、渥美 達也、石津 明洋.
    • Organizer
      日本リウマチ学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超高周波プローブを用いたSuperb Micro-vascular Imagingによる超音波検査でのラット足関節の早期関節炎診断.2018

    • Author(s)
      西田 睦、谷村 瞬、神島 保、西端 友香、益田 紗季子、中沢 大悟、外丸 詩野、渥美 達也、石津 明洋.
    • Organizer
      日本リウマチ学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 免疫グロブリン製剤は好中球細胞外トラップ(NETs)の形成抑制を介してMPO-ANCA関連血管炎(MPO-AAV)の発症を抑制する.2018

    • Author(s)
      魚住 諒、益田 紗季子、西端 友香、谷村 瞬、中沢 大悟、外丸 詩野、石津 明洋.
    • Organizer
      日本リウマチ学会総会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 北海道大学大学院 医学研究院 分子病理学教室 HP

    • URL

      http://path1.med.hokudai.ac.jp/path1/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞傷害性T細胞(CTL)活性化用組成物2020

    • Inventor(s)
      笠原正典, 外丸詩野 他
    • Industrial Property Rights Holder
      笠原正典, 外丸詩野 他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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