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Search for molecular targets and development of integrated molecular and clinical risk classification using a large case series of thyroid cancer in Japan

Research Project

Project/Area Number 18H02635
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

TAKEUCHI Kengo  公益財団法人がん研究会, がん研究所 分子標的病理プロジェクト, プロジェクトリーダー (40323612)

Co-Investigator(Kenkyū-buntansha) 杉谷 巌  日本医科大学, 大学院医学研究科, 大学院教授 (50465936)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords甲状腺癌 / ドライバー変異 / リスク分類
Outline of Final Research Achievements

With regard to the distribution of known driver mutations in papillary thyroid carcinoma in Japanese patients, BRAF V600E was found to be present in about 80%, NRAS Q61R in about 1%, and fusion gene in about 6% (driver mutation unknown: about 13%). In anaplastic carcinomas, BRAF V600E was found to be present in about 84% of cases.
In patients with 1- to 4-cm intrathyroidal papillary carcinoma (PTC), for which no clear indication for lobectomy (LT) or total thyroidectomy (TT) has been established, LT instead of TT can prevent overtreatment and reduce postoperative complications without compromising the outcome if the TERT promoter mutations are negative.

Academic Significance and Societal Importance of the Research Achievements

日本人における甲状腺癌のドライバー遺伝子変異・分子標的profileを明らかにし、また詳細な臨床データと分子異常の統合解析により術式選択に関する「分子・臨床統合的リスク分類」を策定したことで、日本人の甲状腺癌診療成績の向上に資することができると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (9 results)

All 2021 2020

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (4 results) (of which Invited: 4 results)

  • [Journal Article] Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma2021

    • Author(s)
      Sugitani Iwao、Ito Yasuhiro、Takeuchi Dai、Nakayama Hirotaka、Masaki Chie、Shindo Hisakazu、Teshima Masanori、Horiguchi Kazuhiko、Yoshida Yusaku、Kanai Toshiharu、Hirokawa Mitsuyoshi、Hames Kiyomi Y.、Tabei Isao、Miyauchi Akira
    • Journal Title

      Thyroid

      Volume: 31 Issue: 2 Pages: 183-192

    • DOI

      10.1089/thy.2020.0330

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TERT Promoter Mutation and Extent of Thyroidectomy in Patients with 1?4 cm Intrathyroidal Papillary Carcinoma2020

    • Author(s)
      Ebina Aya、Togashi Yuki、Baba Satoko、Sato Yukiko、Sakata Seiji、Ishikawa Masashi、Mitani Hiroki、Takeuchi Kengo、Sugitani Iwao
    • Journal Title

      Cancers

      Volume: 12 Issue: 8 Pages: 2115-2115

    • DOI

      10.3390/cancers12082115

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microarray analysis of formalin-fixed, paraffin-embedded follicular thyroid carcinoma samples from patients who developed postoperative distant metastasis2020

    • Author(s)
      Tomoo Jikuzono, Tomoko Ishikawa, Mitsuyoshi Hirokawa, Iwao Sugitani, Osamu Ishibashi
    • Journal Title

      BMS Res Notes

      Volume: 13: 241 May Issue: 1 Pages: 1-4

    • DOI

      10.1186/s13104-020-05080-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Patient Age With Progression of Low-risk Papillary Thyroid Carcinoma Under Active Surveillance2020

    • Author(s)
      Koshkina Alexandra、Fazelzad Rouhi、Sugitani Iwao、Miyauchi Akira、Thabane Lehana、Goldstein David P.、Ghai Sangeet、Sawka Anna M.
    • Journal Title

      JAMA Otolaryngology?Head & Neck Surgery

      Volume: 146 Issue: 6 Pages: 552-552

    • DOI

      10.1001/jamaoto.2020.0368

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the 8th Edition TNM Classification for Anaplastic Thyroid Carcinoma2020

    • Author(s)
      Onoda Naoyoshi、Sugitani Iwao、Ito Ken-ichi、Suzuki Akifumi、Higashiyama Takuya、Fukumori Tatsuya、Suganuma Nobuyasu、Masudo Katsuhiko、Nakayama Hirotaka、Uno Atsuhiko、Yane Katsunari、Yoshimoto Seiichi、Ebina Aya、Kawasaki Yukari、Maeda Shigeto、Iwadate Manabu、Suzuki Shinichi
    • Journal Title

      Cancers

      Volume: 12 Issue: 3 Pages: 552-552

    • DOI

      10.3390/cancers12030552

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 甲状腺未分化癌の全身療法:レンバチニブを超えて2020

    • Author(s)
      杉谷 巌
    • Organizer
      第93回日本内分泌学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 甲状腺超低リスク乳頭癌のアクティブ・サーベイランス2020

    • Author(s)
      杉谷 巌
    • Organizer
      第21回日本内分泌学会関東甲信越支部学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 超低リスク乳頭癌に対する積極的経過観察の実際とアウトカム2020

    • Author(s)
      杉谷 巌
    • Organizer
      第63回 日本甲状腺学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 成人の甲状腺微小乳頭癌の取扱いに関する実態調査とそれに基づく日本内分泌外科学会甲状腺微小癌取扱い委員会による提言(Consensus statements)の制作2020

    • Author(s)
      杉谷 巌
    • Organizer
      第53回日本内分泌外科学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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