| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In autoimmune diseases such as rheumatoid arthritis, it is urgently necessary to establish novel fundamental therapies based on understanding the mechanism. In this study, we aimed to clarify the molecular mechanisms that govern the pathogenic T cells we identified previously as well as synovial fibroblasts which interact with the pathogenic T cells. By genetic analysis, we proved that synovial fibroblasts are primary cells that induce bone erosion in arthritis in vivo, suggesting the importance of the pathogenic T -synovial fibroblast axis in arthritis. We further clarified a part of the molecular mechanisms that explain pathogenic T cells and synovial fibroblasts. This study will contribute to the establishment of novel therapies for autoimmune diseases including rheumatoid arthritis.
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