The role of Atg family members on autophagy independent pathway
| Project/Area Number |
18H02642
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Osaka University |
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Principal Investigator |
SASAI Miwa 大阪大学, 微生物病研究所, 准教授 (30631551)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | オートファジー非依存的 / インフラマソーム / 非標準オートファジー / オートファジー / Atg遺伝子 / 炎症性サイトカイン / Atg / 炎症 |
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| Outline of Final Research Achievements |
Autophagy-related genes have been considered to be molecules that are responsible for the phenomenon of Autophagy. Recently, however, individual autophagy-related genes have been reported to be individually involved in biological phenomena that are completely different from the phenomenon of Autophagy. In this study, we found that Gate-16 and GABARAP, among the Atg8 family genes, are involved in the negative regulation of the caspase-11-dependent non-canonical inflammasome, which is activated upon recognition of LPS in the cell.
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| Academic Significance and Societal Importance of the Research Achievements |
インフラマソームは細菌の出す毒素や金属・結晶などによる細胞傷害といった生体における異物や異変などを認識すると活性化し、強い炎症性サイトカインや細胞死を誘導する免疫システムであるが、その活性化は厳密に制御された状況下でないと、自己免疫疾患を誘導してしまうことが知られている。本研究では、インフラマソームの中でも細胞内LPSを認識してカスパーゼ11が活性化される非標準インフラマソームが、一部のAtg8遺伝子によって負に制御されていることを証明したことから、自己免疫疾患の発症を抑えている新たな分子を同定したことになり、この遺伝子の変異は自己免疫疾患の発症となり得ることを示した。
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] TFEB-mediated lysosomal exocytosis alleviates high fat diet?induced lipotoxicity in the kidney.2023
Author(s)
Nakmura J, Yamamoto T*, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y.
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Journal Title
JCI Insight
Volume: 8(4)
Issue: 4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota2021
Author(s)
Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae & Eun- Kyeong Jo
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Journal Title
Autophagy
Volume: 10
Issue: 10
Pages: 2856-2857
DOI
Related Report
Peer Reviewed
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[Journal Article] Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.2019
Author(s)
Lee, Y., Yamada, H., Pradipta, A., Ma, J.S., Okamoto, M., Nagaoka, H., Takashima, E., Standley, D.M., Sasai, M., Takei, K., Yamamoto, M.
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Journal Title
Life Science Alliance
Volume: 3
Issue: 1
Pages: 000-000
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] CXCR4 regulates Plasmodium development in mouse and human hepatocytes2019
Author(s)
Bando Hironori、Pradipta Ariel、Iwanaga Shiroh、Okamoto Toru、Okuzaki Daisuke、Tanaka Shun、Vega-Rodr?guez Joel、Lee Youngae、Ma Ji Su、Sakaguchi Naoya、Soga Akira、Fukumoto Shinya、Sasai Miwa、Matsuura Yoshiharu、Yuda Masao、Jacobs-Lorena Marcelo、Yamamoto Masahiro
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Journal Title
Journal of Experimental Medicine
Volume: 216
Issue: 8
Pages: 1733-1748
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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