| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Group 2 innate lymphoid cells (ILC2s) preferentially develop in the lung and contribute to acute allergic inflammation. We clarified physiological roles of transcription factor family Runx proteins in regulating ILC2 homeostasis and activity in a cell-intrinsic or cell-extrinsic manner. ILC2s deficient for Runx protein function fell into exhausted-like low reactivity during severe allergic airway inflammation, leading to decreased allergic inflammation mediated by decreased eosinophil recruitment. We also identified exhausted-like ILC2s expressing Tigit and IL-10 in airways of wild type mice with severe and chronic allergy. Furthermore, Runx deficiency in lung epithelial cells or stromal cells decreased ILC2 number in the lung. Our data also suggested that Runx proteins in epithelial cells are involved in the reduction of lung ILC2s. Thus, Runx proteins are key transcription factors in the maintenance of ILC2 activity and number in the lung.
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